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On the cover: Progression of parotid carcinogenesis in BALB-neuT/p53^172R-H mice. Mice transgenic for r-Her-2/neu and for a mutated form of p53 develop parotid gland carcinomas. Although the cells of early lesions strongly overexpress membrane and cytoplasmic r-p185, in situ carcinomas are less intensely r-p185⁺, and invasive carcinomas almost completely lose r-p185 expression. Pannellini, T., M. Spadaro, E. Di Carlo, E. Ambrosino, M. Iezzi, A. Amici, P. L. Lollini, G. Forni, F. Cavallo, and P. Musiani. 2006. Timely DNA vaccine combined with systemic IL-12 prevents parotid carcinomas before a dominant-negative p53 makes their growth independent of HER-2/neu expression. J. Immunol. 176: 7695–7703.

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