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On the cover: The three-dimensional structure of mouse CD1d bound to phosphatidylcholine (electron density of the ligand shown as a mesh) clarifies the structural restraints in lipid Ag selection. Novel insights are provided into the mode of interaction with the TCR of regulatory NKT cells. Giabbai, B., S. Sidobre, M. Crispin, Y. Sanchez-Ruìz, A. Bachi, M. Kronenberg, I. A. Wilson, and M. Degano. 2005. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. J. Immunol. 175: 977-984.
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