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On the cover: MRL/lpr mice deficient for WSX-1 (IL-27R) develop glomerulonephritis that is identical to human membranous glomerulonephritis with spike-like alterations of basement membranes. Th2-dominant immune responses due to lack of IL-27 signaling support the development of membranous glomerulonephritis, in place of the diffuse proliferative glomerulonephritis observed in wild-type MRL/lpr mice. Shimizu, S., N. Sugiyama, K. Masutani, A. Sadanaga, Y. Miyazaki, Y. Inoue, M. Akahoshi, R. Katafuchi, H. Hirakata, M. Harada, S. Hamano, H. Nakashima, and H. Yoshida. 2005. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J. Immunol. 175: 7185-7192.
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