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On the cover: Reactivation of autoaggressive CD4+ memory T cells in lymph nodes. The activated memory T cells (green) display enlarged nuclei and cytoplasms with enhanced expression of their transgene green fluorescent protein four days following exposure to their cognate Ag. Confocal microscopy with Topro staining (red) labeling nuclei of LN cells. Kawakami, N., F. Odoardi, T. Ziemssen, M. Bradl, T. Ritter, O. Neuhaus, H. Lassmann, H. Wekerle, and A. Flügel. 2005. Autoimmune CD4+ T cell memory: lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. J. Immunol. 175: 69-81.
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