HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

On the cover: Adoptive cellular therapy using naturally occurring CD4⁺CD25^_ T helper cells can help tumor/self-reactive CD8⁺ T cells break tolerance to a nonmutated, self-Ag (autoimmune vitiligo; as shown) and cause the regression of established melanoma through an IL-2-dependent mechanism. Therapy requires the absence of naturally occurring CD4⁺CD25⁺ T regulatory cells to be effective. Antony et al. CD8⁺ T Cell Immunity against a Tumor/Self-Antigen Is Augmented by CD4⁺ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells. J. Immunol. 174:2591.

[Table of Contents]