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On the cover: DA.F344(Cia5) rats congenic for a chromosome 10 interval preserve a nearly normal joint architecture (H&E staining shown here), contrasting with severe disease with extensive synovial hyperplasia, pannus formation, and cartilage and bone erosions observed in DA rats with pristane-induced arthritis. The Cia5 interval contains three different arthritis-regulatory genes. Brenner, M., H.-C. Meng, N. C. Yarlett, B. Joe, M. M. Griffiths, E. F. Remmers, R. L. Wilder, and P. S. Gulko. 2005. The non-MHC quantitative trait locus Cia5 contains three major arthritis genes that differentially regulate disease severity, pannus formation, and joint damage in collagen- and pristane-induced arthritis. J. Immunol. 174: 7894–7903.
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