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On the cover: Following infection with the gut-dwelling helminth Trichuris muris, WSX-1-/- mice develop hyper Th2 cytokine responses and rapid immunity to infection. Staining for intracellular mucins (blue) in the infected large intestine revealed exaggerated goblet cell hyperplasia in infected WSX-1-/- mice, demonstrating that IL-27-WSX-1 interactions negatively regulate mucosal type 2 responses. Artis et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173:5626.
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