IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2004 172: 4659-4660. [Full Text] [PDF]  

BRIEF REVIEWS:

Regulation of T Lymphocyte Metabolism

Kenneth A. Frauwirth and Craig B. Thompson
J Immunol 2004 172: 4661-4665. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase C and NF-B

Aleksandar K. Stanic, Jelena S. Bezbradica, Jang-June Park, Luc Van Kaer, Mark R. Boothby, and Sebastian Joyce
J Immunol 2004 172: 4667-4671. [Abstract] [Full Text] [PDF]  

Cutting Edge: Early IL-4 Production Governs the Requirement for IL-27-WSX-1 Signaling in the Development of Protective Th1 Cytokine Responses following Leishmania major Infection

David Artis, Leanne M. Johnson, Karen Joyce, Christiaan Saris, Alejandro Villarino, Christopher A. Hunter, and Phillip Scott
J Immunol 2004 172: 4672-4675. [Abstract] [Full Text] [PDF]  

Cutting Edge: Human CD4⁺CD25⁺ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells

Namita Misra, Jagadeesh Bayry, Sébastien Lacroix-Desmazes, Michel D. Kazatchkine, and Srini V. Kaveri
J Immunol 2004 172: 4676-4680. [Abstract] [Full Text] [PDF]  

Cutting Edge: Optical Microspectrophotometry Supports the Existence of Gel Phase Lipid Rafts at the Lamellipodium of Neutrophils: Apparent Role in Calcium Signaling

Andrei L. Kindzelskii, Robert G. Sitrin, and Howard R. Petty
J Immunol 2004 172: 4681-4685. [Abstract] [Full Text] [PDF]  

Cutting Edge: Ligation of the Glucocorticoid-Induced TNF Receptor Enhances Autoreactive CD4⁺ T Cell Activation and Experimental Autoimmune Encephalomyelitis

Adam P. Kohm, Julie S. Williams, and Stephen D. Miller
J Immunol 2004 172: 4686-4690. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Preferential Activation of an IL-2 Regulatory Sequence Transgene in TCR and NKT Cells: Subset-Specific Differences in IL-2 Regulation

Mary A. Yui, Leslie L. Sharp, Wendy L. Havran, and Ellen V. Rothenberg
J Immunol 2004 172: 4691-4699. [Abstract] [Full Text] [PDF]  

Requirements for Follicular Exclusion and Competitive Elimination of Autoantigen-Binding B Cells

Eric H. Ekland, Reinhold Forster, Martin Lipp, and Jason G. Cyster
J Immunol 2004 172: 4700-4708. [Abstract] [Full Text] [PDF]  

B Cell-Dependent TCR Diversification

Cristina João, Brenda M. Ogle, Carlota Gay-Rabinstein, Jeffrey L. Platt, and Marilia Cascalho
J Immunol 2004 172: 4709-4716. [Abstract] [Full Text] [PDF]  

Macrophages and Stromal Cells Phagocytose Apoptotic Bone Marrow-Derived B Lineage Cells

Zeynep Dogusan, Encarnacion Montecino-Rodriguez, and Kenneth Dorshkind
J Immunol 2004 172: 4717-4723. [Abstract] [Full Text] [PDF]  

Cellular FLIP Long Form-Transgenic Mice Manifest a Th2 Cytokine Bias and Enhanced Allergic Airway Inflammation

Wenfang Wu, Lisa Rinaldi, Karen A. Fortner, Jennifer Q. Russell, Jürg Tschopp, Charles Irvin, and Ralph C. Budd
J Immunol 2004 172: 4724-4732. [Abstract] [Full Text] [PDF]  

A Toll-Like Receptor 2 Ligand Stimulates Th2 Responses In Vivo, via Induction of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and c-Fos in Dendritic Cells

Stephanie Dillon, Anshu Agrawal, Thomas Van Dyke, Gary Landreth, Laurie McCauley, Amy Koh, Charles Maliszewski, Shizuo Akira, and Bali Pulendran
J Immunol 2004 172: 4733-4743. [Abstract] [Full Text] [PDF]  

Carbon Monoxide Produced by Heme Oxygenase-1 Suppresses T Cell Proliferation via Inhibition of IL-2 Production

Hyun-Ock Pae, Gi-Su Oh, Byung-Min Choi, Soo-Cheon Chae, Young-Myeong Kim, Khee-Rhin Chung, and Hun-Taeg Chung
J Immunol 2004 172: 4744-4751. [Abstract] [Full Text] [PDF]  

Feline Immunodeficiency Virus Infection Phenotypically and Functionally Activates Immunosuppressive CD4⁺CD25⁺ T Regulatory Cells

Thomas W. Vahlenkamp, Mary B. Tompkins, and Wayne A. F. Tompkins
J Immunol 2004 172: 4752-4761. [Abstract] [Full Text] [PDF]  

Enhanced Tumor Responses to Dendritic Cells in the Absence of CD8-Positive Cells

Antoni Ribas, Jennifer A. Wargo, Begonya Comin-Anduix, Shelley Sanetti, Lana Y. Schumacher, Colin McLean, Vivian B. Dissette, John A. Glaspy, William H. McBride, Lisa H. Butterfield, and James S. Economou
J Immunol 2004 172: 4762-4769. [Abstract] [Full Text] [PDF]  

STAT5 Activation Underlies IL7 Receptor-Dependent B Cell Development

Christine A. Goetz, Ian R. Harmon, Jennifer J. O’Neil, Matthew A. Burchill, and Michael A. Farrar
J Immunol 2004 172: 4770-4778. [Abstract] [Full Text] [PDF]  

Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation

Ping-Ying Pan, Peidi Gu, Qingsheng Li, Dongping Xu, Kaare Weber, and Shu-Hsia Chen
J Immunol 2004 172: 4779-4789. [Abstract] [Full Text] [PDF]  

Analysis of Mutational Lineage Trees from Sites of Primary and Secondary Ig Gene Diversification in Rabbits and Chickens

Ramit Mehr, Hanna Edelman, Devinder Sehgal, and Rose Mage
J Immunol 2004 172: 4790-4796. [Abstract] [Full Text] [PDF]  

The Novel Cyclophilin Binding Compound, Sanglifehrin A, Disassociates G₁ Cell Cycle Arrest from Tolerance Induction

Amy Allen, Yan Zheng, Lawrence Gardner, Meredith Safford, Maureen R. Horton, and Jonathan D. Powell
J Immunol 2004 172: 4797-4803. [Abstract] [Full Text] [PDF]  

CD40 Ligation In Vivo Induces Bystander Proliferation of Memory Phenotype CD8 T Cells

Marie Koschella, David Voehringer, and Hanspeter Pircher
J Immunol 2004 172: 4804-4811. [Abstract] [Full Text] [PDF]  

Active Protein Kinase B Regulates TCR Responsiveness by Modulating Cytoplasmic-Nuclear Localization of NFAT and NF-B Proteins

Amiya K. Patra, Shin-Young Na, and Ursula Bommhardt
J Immunol 2004 172: 4812-4820. [Abstract] [Full Text] [PDF]  

Costimulation of CD8 T Cell Responses by OX40

Pratima Bansal-Pakala, Beth S. Halteman, Mary Huey-Yu Cheng, and Michael Croft
J Immunol 2004 172: 4821-4825. [Abstract] [Full Text] [PDF]  

Differential Requirement for the CD40-CD154 Costimulatory Pathway during Th Cell Priming by CD8⁺ and CD8⁻ Murine Dendritic Cell Subsets

Takahiro Yasumi, Kenji Katamura, Takakazu Yoshioka, Taka-aki Meguro, Ryuta Nishikomori, Toshio Heike, Manabu Inobe, Shigeyuki Kon, Toshimitsu Uede, and Tatsutoshi Nakahata
J Immunol 2004 172: 4826-4833. [Abstract] [Full Text] [PDF]  

Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Macrophages from Nonobese Diabetic and Systemic Lupus Erythematosus-Prone Mice

Hanli Fan, Angelika Longacre, Fanyong Meng, Vimal Patel, Kevin Hsiao, Jason S. Koh, and Jerrold S. Levine
J Immunol 2004 172: 4834-4843. [Abstract] [Full Text] [PDF]  

Simultaneous Cellular and Humoral Immune Response against Mutated p53 in a Patient with Lung Cancer

Yoshinobu Ichiki, Mitsuhiro Takenoyama, Makiko Mizukami, Tetsuya So, Masakazu Sugaya, Manabu Yasuda, Tomoko So, Takeshi Hanagiri, Kenji Sugio, and Kosei Yasumoto
J Immunol 2004 172: 4844-4850. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

The Inositol 3-Phosphatase PTEN Negatively Regulates Fc Receptor Signaling, but Supports Toll-Like Receptor 4 Signaling in Murine Peritoneal Macrophages

Xianhua Cao, Guo Wei, Huiqing Fang, Jianping Guo, Michael Weinstein, Clay B. Marsh, Michael C. Ostrowski, and Susheela Tridandapani
J Immunol 2004 172: 4851-4857. [Abstract] [Full Text] [PDF]  

Pax-5 Is Essential for Sterile Transcription during Ig Chain Gene Rearrangement

Hiromu Sato, Fumiko Saito-Ohara, Johji Inazawa, and Akira Kudo
J Immunol 2004 172: 4858-4865. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Listeriolysin O from Listeria monocytogenes Is a Lymphocyte Apoptogenic Molecule

Javier A. Carrero, Boris Calderon, and Emil R. Unanue
J Immunol 2004 172: 4866-4874. [Abstract] [Full Text] [PDF]  

Activated Primary and Memory CD8 T Cells Migrate to Nonlymphoid Tissues Regardless of Site of Activation or Tissue of Origin

David Masopust, Vaiva Vezys, Edward J. Usherwood, Linda S. Cauley, Sara Olson, Amanda L. Marzo, Richard L. Ward, David L. Woodland, and Leo Lefrançois
J Immunol 2004 172: 4875-4882. [Abstract] [Full Text] [PDF]  

Burn Injury Initiates a Shift in Superantigen-Induced T Cell Responses and Host Survival

Yan Zang, Sinead M. Dolan, Niamh Ni Choileain, Sara J. Kriynovich, Thomas J. Murphy, Peter Sayles, John A. Mannick, and James A. Lederer
J Immunol 2004 172: 4883-4892. [Abstract] [Full Text] [PDF]  

CTLA-4 Blockage Increases Resistance to Infection with the Intracellular Protozoan Trypanosoma cruzi

Gislâine Aparecida Martins, Carlos Eduardo Tadokoro, Roberta Borges Silva, João Santana Silva, and Luiz Vicente Rizzo
J Immunol 2004 172: 4893-4901. [Abstract] [Full Text] [PDF]  

A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3

Lukasz Kedzierski, Jacqui Montgomery, Denise Bullen, Joan Curtis, Elizabeth Gardiner, Antonio Jimenez-Ruiz, and Emanuela Handman
J Immunol 2004 172: 4902-4906. [Abstract] [Full Text] [PDF]  

Selective Impairments in Dendritic Cell-Associated Function Distinguish Hepatitis C Virus and HIV Infection

Donald D. Anthony, Nicole L. Yonkers, Anthony B. Post, Robert Asaad, Frederick P. Heinzel, Michael M. Lederman, Paul V. Lehmann, and Hernan Valdez
J Immunol 2004 172: 4907-4916. [Abstract] [Full Text] [PDF]  

Timed Ablation of Regulatory CD4⁺ T Cells Can Prevent Murine AIDS Progression

Manfred W. Beilharz, Leanne M. Sammels, Andrea Paun, Kathryn Shaw, Pauline van Eeden, Mark W. Watson, and Martin L. Ashdown
J Immunol 2004 172: 4917-4925. [Abstract] [Full Text] [PDF]  

Malaria Blood Stage Parasites Activate Human Plasmacytoid Dendritic Cells and Murine Dendritic Cells through a Toll-Like Receptor 9-Dependent Pathway

Sathit Pichyangkul, Kosol Yongvanitchit, Utaiwan Kum-arb, Hiroaki Hemmi, Shizuo Akira, Arthur M. Krieg, D. Gray Heppner, V. Ann Stewart, Hitoshi Hasegawa, Sornchai Looareesuwan, G. Dennis Shanks, and R. Scott Miller
J Immunol 2004 172: 4926-4933. [Abstract] [Full Text] [PDF]  

Effective Targeting of Pathogens to Neutrophils via Chimeric Surfactant Protein D/Anti-CD89 Protein

Paul J. Tacken, Kevan L. Hartshorn, Mitchell R. White, Cees van Kooten, Jan G. J. van de Winkel, Ken B. M. Reid, and Joseph J. Batenburg
J Immunol 2004 172: 4934-4940. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

IFN- Induces gp91^phox Expression in Human Monocytes via Protein Kinase C-Dependent Phosphorylation of PU.1

Paola Mazzi, Marta Donini, Daniela Margotto, Frans Wientjes, and Stefano Dusi
J Immunol 2004 172: 4941-4947. [Abstract] [Full Text] [PDF]  

Janus Kinase 3 Down-Regulates Lipopolysaccharide-Induced IL-1-Converting Enzyme Activation by Autocrine IL-10

Hee-Jung Kim, Judy Hart, Nina Knatz, Mark W. Hall, and Mark D. Wewers
J Immunol 2004 172: 4948-4955. [Abstract] [Full Text] [PDF]  

Triggering Receptor Expressed on Myeloid Cells-1 in Neutrophil Inflammatory Responses: Differential Regulation of Activation and Survival

Markus P. Radsak, Helmut R. Salih, Hans-Georg Rammensee, and Hansjörg Schild
J Immunol 2004 172: 4956-4963. [Abstract] [Full Text] [PDF]  

Mast Cell-Independent Mechanisms of Immediate Hypersensitivity: A Role for Platelets

Denise C. Cara, Kirsten V. J. Ebbert, and Donna-Marie McCafferty
J Immunol 2004 172: 4964-4971. [Abstract] [Full Text] [PDF]  

Differential Recognition and Scavenging of Native and Truncated Macrophage-Derived Chemokine (Macrophage-Derived Chemokine/CC Chemokine Ligand 22) by the D6 Decoy Receptor

Raffaella Bonecchi, Massimo Locati, Emanuela Galliera, Marisa Vulcano, Marina Sironi, Anna M. Fra, Marco Gobbi, Annunciata Vecchi, Silvano Sozzani, Bodduluri Haribabu, Jo Van Damme, and Alberto Mantovani
J Immunol 2004 172: 4972-4976. [Abstract] [Full Text] [PDF]  

Toll-Like Receptor (TLR)2 and TLR4 Agonists Regulate CCR Expression in Human Monocytic Cells

Lisa C. Parker, Moira K. B. Whyte, Stefanie N. Vogel, Steven K. Dower, and Ian Sabroe
J Immunol 2004 172: 4977-4986. [Abstract] [Full Text] [PDF]  

A Novel P2X₇ Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1 Processing and Release

Andreas Elssner, Michelle Duncan, Mikhail Gavrilin, and Mark D. Wewers
J Immunol 2004 172: 4987-4994. [Abstract] [Full Text] [PDF]  

Transient Corticosteroid Treatment Permanently Amplifies the Th2 Response in a Murine Model of Asthma

Ryan E. Wiley, Monika Cwiartka, David Alvarez, David C. Mackenzie, Jill R. Johnson, Susanna Goncharova, Lennart Lundblad, and Manel Jordana
J Immunol 2004 172: 4995-5005. [Abstract] [Full Text] [PDF]  

Overexpression of Serum Amyloid A-Activating Factor 1 Inhibits Cell Proliferation by the Induction of Cyclin-Dependent Protein Kinase Inhibitor p21^{WAF-1/Cip-1/Sdi-1} Expression

Alpana Ray, Arvind Shakya, Deepak Kumar, and Bimal K. Ray
J Immunol 2004 172: 5006-5015. [Abstract] [Full Text] [PDF]  

Flt-3 Ligand Reverses Late Allergic Response and Airway Hyper-Responsiveness in a Mouse Model of Allergic Inflammation

Jehad H. Edwan, Greg Perry, James E. Talmadge, and Devendra K. Agrawal
J Immunol 2004 172: 5016-5023. [Abstract] [Full Text] [PDF]  

Helicobacter pylori-Specific Antibodies Impair the Development of Gastritis, Facilitate Bacterial Colonization, and Counteract Resistance against Infection

Ali A. Akhiani, Karin Schön, Lennart E. Franzén, Jacques Pappo, and Nils Lycke
J Immunol 2004 172: 5024-5033. [Abstract] [Full Text] [PDF]  

CXCL1/Macrophage Inflammatory Protein-2-Induced Angiogenesis In Vivo Is Mediated by Neutrophil-Derived Vascular Endothelial Growth Factor-A

Patrizia Scapini, Monica Morini, Cristina Tecchio, Simona Minghelli, Emma Di Carlo, Elena Tanghetti, Adriana Albini, Clifford Lowell, Giorgio Berton, Douglas M. Noonan, and Marco A. Cassatella
J Immunol 2004 172: 5034-5040. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Does HLA-Dependent Chimerism Underlie the Pathogenesis of Juvenile Dermatomyositis?

Ann M. Reed, Kelly McNallan, Peter Wettstein, Richard Vehe, and Carole Ober
J Immunol 2004 172: 5041-5046. [Abstract] [Full Text] [PDF]  

Strain Distribution Pattern of Susceptibility to Immune-Mediated Nephritis

Chun Xie, Ruchi Sharma, Hongwei Wang, Xin J. Zhou, and Chandra Mohan
J Immunol 2004 172: 5047-5055. [Abstract] [Full Text] [PDF]  

Human Intestinal Microvascular Endothelial Cells Express Toll-Like Receptor 5: A Binding Partner for Bacterial Flagellin

Christian Maaser, Jan Heidemann, Christof von Eiff, Andreas Lugering, Thomas W. Spahn, David G. Binion, Wolfram Domschke, Norbert Lugering, and Torsten Kucharzik
J Immunol 2004 172: 5056-5062. [Abstract] [Full Text] [PDF]  

Matrix Metalloproteinases as Targets for the Immune System during Experimental Arthritis

Jolanda H. M. van Bilsen, Josée P. A. Wagenaar-Hilbers, Mayken C. J. T. Grosfeld-Stulemeijer, Maarten J. F. van der Cammen, Mariska E. A. van Dijk, Willem van Eden, and Marca H. M. Wauben
J Immunol 2004 172: 5063-5068. [Abstract] [Full Text] [PDF]  

Thymocyte-Intrinsic Genetic Factors Influence CD8 T Cell Lineage Commitment and Affect Selection of a Tumor-Reactive TCR

Anil Shanker, Nathalie Auphan-Anezin, Patrick Chomez, Laurent Giraudo, Benoît Van den Eynde, and Anne-Marie Schmitt-Verhulst
J Immunol 2004 172: 5069-5077. [Abstract] [Full Text] [PDF]  

A Novel Locus Regulates Both Retroviral Glycoprotein 70 and Anti-Glycoprotein 70 Antibody Production in New Zealand Mice When Crossed with BALB/c

Robert J. Rigby, Stephen J. Rozzo, Herpreet Gill, Timothy Fernandez-Hart, Bernard J. Morley, Shozo Izui, Brian L. Kotzin, and Timothy J. Vyse
J Immunol 2004 172: 5078-5085. [Abstract] [Full Text] [PDF]  

B Cell Selection Defects Underlie the Development of Diabetogenic APCs in Nonobese Diabetic Mice

Pablo A. Silveira, Joseph Dombrowsky, Ellis Johnson, Harold D. Chapman, David Nemazee, and David V. Serreze
J Immunol 2004 172: 5086-5094. [Abstract] [Full Text] [PDF]  

Identification of Multiple HLA-DR-Restricted Epitopes of the Tumor-Associated Antigen CAMEL by CD4⁺ Th1/Th2 Lymphocytes

Elisabeth H. Slager, Caroline E. van der Minne, Margreet Krüse, Dilja D. Krueger, Marieke Griffioen, and Susanne Osanto
J Immunol 2004 172: 5095-5102. [Abstract] [Full Text] [PDF]  

Thalidomide Induces Apoptosis in Human Monocytes by Using a Cytochrome c-Dependent Pathway

Henning R. Gockel, Andreas Lügering, Jan Heidemann, Michael Schmidt, Wolfram Domschke, Torsten Kucharzik, and Norbert Lügering
J Immunol 2004 172: 5103-5109. [Abstract] [Full Text] [PDF]  

HLA-B27 in Transgenic Rats Forms Disulfide-Linked Heavy Chain Oligomers and Multimers That Bind to the Chaperone BiP

Tri Minh Tran, Nimman Satumtira, Martha L. Dorris, Ekkehard May, Andrew Wang, Eiichi Furuta, and Joel D. Taurog
J Immunol 2004 172: 5110-5119. [Abstract] [Full Text] [PDF]  

Increased CD8⁺ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis

Ying C. Q. Zang, Sufang Li, Victor M. Rivera, Jian Hong, Rachel R. Robinson, Wini T. Breitbach, James Killian, and Jingwu Z. Zhang
J Immunol 2004 172: 5120-5127. [Abstract] [Full Text] [PDF]  

CORRECTIONS:

Studies of Structure-Activity Relations of Complement Inhibitor Compstatin.

Athena M. Soulika, Dimitrios Morikis, Maria-Rosa Sarrias, Melinda Roy, Lynn A. Spruce, Arvind Sahu, and John D. Lambris
J Immunol 2004 172: 5128. [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor-Deficient Heterozygous Mice Develop an Exacerbated Neural Antigen-Induced Th1 Response and Experimental Allergic Encephalomyelitis.

John J. Bright, Chandramohan Natarajan, Gladson Muthian, Yaavov Barak, and Ronald M. Evans
J Immunol 2004 172: 5128. [Full Text] [PDF]  

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions.

Patricia A. Taylor, Christopher J. Lees, Sylvie Fournier, James P. Allison, Arlene H. Sharpe, and Bruce R. Blazer
J Immunol 2004 172: 5128. [Full Text] [PDF]  

Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL.

Bing He, Amy Chadburn, Erin Jou, Elaine J. Schattner, Daniel M. Knowles, and Andrea Cerutti
J Immunol 2004 172: 5128. [Full Text] [PDF]  

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