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On the cover: Narrowed vascular lumen due to intimal thickening in a heart allograft undergoing chronic rejection. Chronic rejection developed when healed-in heart grafts were subjected to effector T cells. In contrast, the same effector T cells caused the acute rejection of newly transplanted hearts. Chalasani et al. The allograft defines the type of rejection (acute versus chronic) in the face of an established effector immune response. J. Immunol. 172:7813.
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