IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2004 172: 5811-5812. [Full Text] [PDF]  

LETTERS TO THE EDITOR:

A. actinomycetemcomitans Cytolethal Distending Toxin

Monica Thelestam and Teresa Frisan
J Immunol 2004 172: 5813. [Full Text] [PDF]  

The Authors Respond

Bruce J. Shenker and Donald Demuth
J Immunol 2004 172: 5813-5814. [Full Text] [PDF]  

BRIEF REVIEWS:

DNA Acrobats of the Ig Class Switch

Clifford L. Wang and Matthias Wabl
J Immunol 2004 172: 5815-5821. [Abstract] [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: The Natural Ligand for Glucocorticoid-Induced TNF Receptor-Related Protein Abrogates Regulatory T Cell Suppression

Hong-bin Ji, Gongxian Liao, William A. Faubion, Ana C. Abadía-Molina, Cristina Cozzo, F. Stephen Laroux, Andrew Caton, and Cox Terhorst
J Immunol 2004 172: 5823-5827. [Abstract] [Full Text] [PDF]  

Cutting Edge: Extracellular Signal-Regulated Kinases 1/2 Function as Integrators of TCR Signal Strength

Andrew E. Schade and Alan D. Levine
J Immunol 2004 172: 5828-5832. [Abstract] [Full Text] [PDF]  

Cutting Edge: C3d Functions as a Molecular Adjuvant in the Absence of CD21/35 Expression

Karen M. Haas, Franklin R. Toapanta, Julie A. Oliver, Jonathan C. Poe, John H. Weis, David R. Karp, Joseph F. Bower, Ted M. Ross, and Thomas F. Tedder
J Immunol 2004 172: 5833-5837. [Abstract] [Full Text] [PDF]  

Cutting Edge: TREM-Like Transcript-1, a Platelet Immunoreceptor Tyrosine-Based Inhibition Motif Encoding Costimulatory Immunoreceptor that Enhances, Rather than Inhibits, Calcium Signaling via SHP-2

Alexander D. Barrow, Emmanuelle Astoul, Andres Floto, Gary Brooke, Ingrid A. M. Relou, Nicola S. Jennings, Kenneth G. C. Smith, Willem Ouwehand, Richard W. Farndale, Denis R. Alexander, and John Trowsdale
J Immunol 2004 172: 5838-5842. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Shift from Systemic to Site-Specific Memory by Tumor-Targeted IL-2

David Schrama, Rong Xiang, Andreas O. Eggert, Mads Hald Andersen, Lars Østergaard Pedersen, Eckhart Kämpgen, Ton N. Schumacher, Ralph R. Reisfeld, and Jürgen C. Becker
J Immunol 2004 172: 5843-5850. [Abstract] [Full Text] [PDF]  

Evolutionary Origins of Lymphocytes: Ensembles of T Cell and B Cell Transcriptional Regulators in a Cartilaginous Fish

Michele K. Anderson, Rashmi Pant, Ann L. Miracle, Xiao Sun, Carl A. Luer, Catherine J. Walsh, Janice C. Telfer, Gary W. Litman, and Ellen V. Rothenberg
J Immunol 2004 172: 5851-5860. [Abstract] [Full Text] [PDF]  

CpG Motifs as Proinflammatory Factors Render Autochthonous Tumors Permissive for Infiltration and Destruction

Natalio Garbi, Bernd Arnold, Siamon Gordon, Günter J. Hämmerling, and Ruth Ganss
J Immunol 2004 172: 5861-5869. [Abstract] [Full Text] [PDF]  

Differential Gene Expression Patterns by Oligonucleotide Microarray of Basal versus Lipopolysaccharide-Activated Monocytes from Cord Blood versus Adult Peripheral Blood

Hong Jiang, Carmella Van de Ven, Prakash Satwani, Laxmi V. Baxi, and Mitchell S. Cairo
J Immunol 2004 172: 5870-5879. [Abstract] [Full Text] [PDF]  

CD28 Signals in the Immature Immunological Synapse

Pietro G. Andres, Kimberly C. Howland, Douglas Dresnek, Samuel Edmondson, Abul K. Abbas, and Matthew F. Krummel
J Immunol 2004 172: 5880-5886. [Abstract] [Full Text] [PDF]  

CD4 Raft Association and Signaling Regulate Molecular Clustering at the Immunological Synapse Site

Fran Balamuth, Jennifer L. Brogdon, and Kim Bottomly
J Immunol 2004 172: 5887-5892. [Abstract] [Full Text] [PDF]  

Depletion of CD8⁺ Cells Abolishes the Pregnancy Protective Effect of Progesterone Substitution with Dydrogesterone in Mice by Altering the Th1/Th2 Cytokine Profile

Sandra M. Blois, Ricarda Joachim, Judith Kandil, Ricardo Margni, Mareike Tometten, Burghard F. Klapp, and Petra C. Arck
J Immunol 2004 172: 5893-5899. [Abstract] [Full Text] [PDF]  

Generation of Anergic and Regulatory T Cells following Prolonged Exposure to a Harmless Antigen

Tse-Ching Chen, Stephen P. Cobbold, Paul J. Fairchild, and Herman Waldmann
J Immunol 2004 172: 5900-5907. [Abstract] [Full Text] [PDF]  

Up-Regulation of CD1d Expression Restores the Immunoregulatory Function of NKT Cells and Prevents Autoimmune Diabetes in Nonobese Diabetic Mice

Marika Falcone, Federica Facciotti, Nadia Ghidoli, Paolo Monti, Stefano Olivieri, Luca Zaccagnino, Ezio Bonifacio, Giulia Casorati, Francesca Sanvito, and Nora Sarvetnick
J Immunol 2004 172: 5908-5916. [Abstract] [Full Text] [PDF]  

The Inducible Costimulator Plays the Major Costimulatory Role in Humoral Immune Responses in the Absence of CD28

Woong-Kyung Suh, Anna Tafuri, Nancy N. Berg-Brown, Arda Shahinian, Suzanne Plyte, Gordon S. Duncan, Hitoshi Okada, Andrew Wakeham, Bernhard Odermatt, Pamela S. Ohashi, and Tak W. Mak
J Immunol 2004 172: 5917-5923. [Abstract] [Full Text] [PDF]  

Heart, but Not Skin, Allografts from Donors Lacking Flt3 Ligand Exhibit Markedly Prolonged Survival Time

Zhiliang Wang, Antonino Castellaneta, An De Creus, William J. Shufesky, Adrian E. Morelli, and Angus W. Thomson
J Immunol 2004 172: 5924-5930. [Abstract] [Full Text] [PDF]  

An Inhibitory Ig Superfamily Protein Expressed by Lymphocytes and APCs Is Also an Early Marker of Thymocyte Positive Selection

Peggy Han, Olivia D. Goularte, Kevin Rufner, Beverley Wilkinson, and Jonathan Kaye
J Immunol 2004 172: 5931-5939. [Abstract] [Full Text] [PDF]  

Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-B Ligand-Induced NF-B Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis

Alok C. Bharti, Yasunari Takada, and Bharat B. Aggarwal
J Immunol 2004 172: 5940-5947. [Abstract] [Full Text] [PDF]  

Conversion of CTLA-4 from Inhibitor to Activator of T Cells with a Bispecific Tandem Single-Chain Fv Ligand

Joaquín Madrenas, Luan A. Chau, Wendy A. Teft, Paul W. Wu, Jason Jussif, Marion Kasaian, Beatriz M. Carreno, and Vincent Ling
J Immunol 2004 172: 5948-5956. [Abstract] [Full Text] [PDF]  

IL-4 Confers NK Stimulatory Capacity to Murine Dendritic Cells: A Signaling Pathway Involving KARAP/DAP12-Triggering Receptor Expressed on Myeloid Cell 2 Molecules

Magali Terme, Elena Tomasello, Koji Maruyama, Florent Crépineau, Nathalie Chaput, Caroline Flament, Jean-Pierre Marolleau, Eric Angevin, Erwin F. Wagner, Benoît Salomon, François A. Lemonnier, Hiro Wakasugi, Marco Colonna, Eric Vivier, and Laurence Zitvogel
J Immunol 2004 172: 5957-5966. [Abstract] [Full Text] [PDF]  

Autoreactive T Cells in Healthy Individuals

Nancy A. Danke, David M. Koelle, Cassian Yee, Sucheta Beheray, and William W. Kwok
J Immunol 2004 172: 5967-5972. [Abstract] [Full Text] [PDF]  

IL-2 Induces a Competitive Survival Advantage in T Lymphocytes

Hans Dooms, Estelle Kahn, Birgit Knoechel, and Abul K. Abbas
J Immunol 2004 172: 5973-5979. [Abstract] [Full Text] [PDF]  

Adult Human Liver Contains CD8^pos T Cells with Naive Phenotype, but Is Not a Site for Conventional T Cell Development

Lucy Golden-Mason, Daniel C. Douek, Richard A. Koup, Jacinta Kelly, John E. Hegarty, and Cliona O’Farrelly
J Immunol 2004 172: 5980-5985. [Abstract] [Full Text] [PDF]  

IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4⁺CD25⁺ Regulatory T Cells

Pedro L. Vieira, Jillian R. Christensen, Sophie Minaee, Emma J. O’Neill, Franck J. Barrat, André Boonstra, Thomas Barthlott, Brigitta Stockinger, David C. Wraith, and Anne O’Garra
J Immunol 2004 172: 5986-5993. [Abstract] [Full Text] [PDF]  

Thymic Expression of a Gastritogenic Epitope Results in Positive Selection of Self-Reactive Pathogenic T Cells

Karen L. Laurie, Nicole L. La Gruta, Norbert Koch, Ian R. van Driel, and Paul A. Gleeson
J Immunol 2004 172: 5994-6002. [Abstract] [Full Text] [PDF]  

Induction of foxP3⁺ Regulatory T Cells in the Periphery of T Cell Receptor Transgenic Mice Tolerized to Transplants

Stephen P. Cobbold, Raquel Castejon, Elizabeth Adams, Diana Zelenika, Luis Graca, Susan Humm, and Herman Waldmann
J Immunol 2004 172: 6003-6010. [Abstract] [Full Text] [PDF]  

The Serotoninergic Receptors of Human Dendritic Cells: Identification and Coupling to Cytokine Release

Marco Idzko, Elisabeth Panther, Christian Stratz, Tobias Müller, Hannes Bayer, Gernot Zissel, Thorsten Dürk, Stephan Sorichter, Francesco Di Virgilio, Michael Geissler, Bernd Fiebich, Yared Herouy, Peter Elsner, Johannes Norgauer, and Davide Ferrari
J Immunol 2004 172: 6011-6019. [Abstract] [Full Text] [PDF]  

The Role of IL-5 for Mature B-1 Cells in Homeostatic Proliferation, Cell Survival, and Ig Production

Byoung-gon Moon, Satoshi Takaki, Kensuke Miyake, and Kiyoshi Takatsu
J Immunol 2004 172: 6020-6029. [Abstract] [Full Text] [PDF]  

The Ability of Two Listeria monocytogenes Vaccines Targeting Human Papillomavirus-16 E7 to Induce an Antitumor Response Correlates with Myeloid Dendritic Cell Function

Xiaohui Peng, S. Farzana Hussain, and Yvonne Paterson
J Immunol 2004 172: 6030-6038. [Abstract] [Full Text] [PDF]  

Stimulation by Soluble CD70 Promotes Strong Primary and Secondary CD8⁺ Cytotoxic T Cell Responses In Vivo

Tania F. Rowley and Aymen Al-Shamkhani
J Immunol 2004 172: 6039-6046. [Abstract] [Full Text] [PDF]  

The Role of the p38 Mitogen-Activated Protein Kinase, Extracellular Signal-Regulated Kinase, and Phosphoinositide-3-OH Kinase Signal Transduction Pathways in CD40 Ligand-Induced Dendritic Cell Activation and Expansion of Virus-Specific CD8⁺ T Cell Memory Responses

Qigui Yu, Colin Kovacs, Feng Yun Yue, and Mario A. Ostrowski
J Immunol 2004 172: 6047-6056. [Abstract] [Full Text] [PDF]  

T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product

Jianping Huang, Mona El-Gamil, Mark E. Dudley, Yong F. Li, Steven A. Rosenberg, and Paul F. Robbins
J Immunol 2004 172: 6057-6064. [Abstract] [Full Text] [PDF]  

Toll-Like Receptor Ligands Directly Promote Activated CD4⁺ T Cell Survival

Andrew E. Gelman, Jidong Zhang, Yongwon Choi, and Laurence A. Turka
J Immunol 2004 172: 6065-6073. [Abstract] [Full Text] [PDF]  

The Tumoricidal Activity of Memory CD8⁺ T Cells Is Hampered by Persistent Systemic Antigen, but Full Functional Capacity Is Regained in an Antigen-Free Environment

Annemieke Th. den Boer, Geertje J. D. van Mierlo, Marieke F. Fransen, Cornelis J. M. Melief, Rienk Offringa, and René E. M. Toes
J Immunol 2004 172: 6074-6079. [Abstract] [Full Text] [PDF]  

The Toll-Like Receptor-2/6 Agonist Macrophage-Activating Lipopeptide-2 Cooperates with IFN- to Reverse the Th2 Skew in an In Vitro Allergy Model

Henning Weigt, Peter F. Muhlradt, Michael Larbig, Norbert Krug, and Armin Braun
J Immunol 2004 172: 6080-6086. [Abstract] [Full Text] [PDF]  

Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II-Restricted Epitopes for In Vivo Presentation, but Selectively Primes CD8⁺ T Cell Effector Function

Amy D. H. Doody, Joseph T. Kovalchin, Marianne A. Mihalyo, Adam T. Hagymasi, Charles G. Drake, and Adam J. Adler
J Immunol 2004 172: 6087-6092. [Abstract] [Full Text] [PDF]  

Restoration of NK T Cell Development in fyn-Mutant Mice by a TCR Reveals a Requirement for Fyn During Early NK T Cell Ontogeny

Paul Gadue, Liqun Yin, Sumesh Jain, and Paul L. Stein
J Immunol 2004 172: 6093-6100. [Abstract] [Full Text] [PDF]  

IL-9-Induced Expansion of B-1b Cells Restores Numbers but Not Function of B-1 Lymphocytes in xid Mice

Laurent Knoops, Jamila Louahed, and Jean-Christophe Renauld
J Immunol 2004 172: 6101-6106. [Abstract] [Full Text] [PDF]  

The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines

Laila E. Gamadia, Ester M. M. van Leeuwen, Ester B. M. Remmerswaal, Si-La Yong, Sugianto Surachno, Pauline M. E. Wertheim-van Dillen, Ineke J. M. ten Berge, and René A. W. van Lier
J Immunol 2004 172: 6107-6114. [Abstract] [Full Text] [PDF]  

CD1d-Independent NKT Cells in ₂-Microglobulin-Deficient Mice Have Hybrid Phenotype and Function of NK and T Cells

Motoi Maeda, Ashleen Shadeo, Anna M. MacFadyen, and Fumio Takei
J Immunol 2004 172: 6115-6122. [Abstract] [Full Text] [PDF]  

Human CD4⁺CD25⁺ Regulatory T Cells Share Equally Complex and Comparable Repertoires with CD4⁺CD25^– Counterparts

Kimberly A. Kasow, Xiaohua Chen, James Knowles, David Wichlan, Rupert Handgretinger, and Janice M. Riberdy
J Immunol 2004 172: 6123-6128. [Abstract] [Full Text] [PDF]  

Loading of MHC Class I and II Presentation Pathways by Exogenous Antigens: A Quantitative In Vivo Comparison

Tazio Storni and Martin F. Bachmann
J Immunol 2004 172: 6129-6135. [Abstract] [Full Text] [PDF]  

IL-2 Secretion by CD4⁺ T Cells In Vivo Is Rapid, Transient, and Influenced by TCR-Specific Competition

Dorothy K. Sojka, Denis Bruniquel, Ronald H. Schwartz, and Nevil J. Singh
J Immunol 2004 172: 6136-6143. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Transcriptional Activation of the SH2D2A Gene Is Dependent on a Cyclic Adenosine 5'-Monophosphate-Responsive Element in the Proximal SH2D2A Promoter

Ke-Zheng Dai, Finn-Eirik Johansen, Kristin Melkevik Kolltveit, Hans-Christian Aasheim, Zlatko Dembic, Frode Vartdal, and Anne Spurkland
J Immunol 2004 172: 6144-6151. [Abstract] [Full Text] [PDF]  

Genetic Makeup of the DR Region in Rhesus Macaques: Gene Content, Transcripts, and Pseudogenes

Nanine de Groot, Gaby G. Doxiadis, Natasja G. de Groot, Nel Otting, Corrine Heijmans, Annemiek J. M. Rouweler, and Ronald E. Bontrop
J Immunol 2004 172: 6152-6157. [Abstract] [Full Text] [PDF]  

IL-4-Induced GATA-3 Expression Is a Time-Restricted Instruction Switch for Th2 Cell Differentiation

Noriyasu Seki, Mayumi Miyazaki, Wataru Suzuki, Katsuhiko Hayashi, Kazuhiko Arima, Elmarie Myburgh, Kenji Izuhara, Frank Brombacher, and Masato Kubo
J Immunol 2004 172: 6158-6166. [Abstract] [Full Text] [PDF]  

Fusion of Two Malaria Vaccine Candidate Antigens Enhances Product Yield, Immunogenicity, and Antibody-Mediated Inhibition of Parasite Growth In Vitro

Weiqing Pan, Daqing Huang, Qingfeng Zhang, Li Qu, Dongmei Zhang, Xiaoli Zhang, Xiangyang Xue, and Feng Qian
J Immunol 2004 172: 6167-6174. [Abstract] [Full Text] [PDF]  

Structures of HLA-A*1101 Complexed with Immunodominant Nonamer and Decamer HIV-1 Epitopes Clearly Reveal the Presence of a Middle, Secondary Anchor Residue

Lenong Li and Marlene Bouvier
J Immunol 2004 172: 6175-6184. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Lipopolysaccharide-Binding Protein Critically Regulates Lipopolysaccharide-Induced IFN- Signaling Pathway in Human Monocytes

Atsushi Kato, Takahisa Ogasawara, Toshiki Homma, Hirohisa Saito, and Kenji Matsumoto
J Immunol 2004 172: 6185-6194. [Abstract] [Full Text] [PDF] Data Supplement  

Lysine-Dependent Multipoint Binding of the Borrelia burgdorferi Virulence Factor Outer Surface Protein E to the C Terminus of Factor H

Antti Alitalo, Taru Meri, Tong Chen, Hilkka Lankinen, Zhu-Zhu Cheng, T. Sakari Jokiranta, Ilkka J. T. Seppälä, Pekka Lahdenne, P. Scott Hefty, Darrin R. Akins, and Seppo Meri
J Immunol 2004 172: 6195-6201. [Abstract] [Full Text] [PDF]  

Toll-Like Receptor 4 Dependence of Innate and Adaptive Immunity to Salmonella: Importance of the Kupffer Cell Network

Andrés Vazquez-Torres, Bruce A. Vallance, Molly A. Bergman, B. Brett Finlay, Brad T. Cookson, Jessica Jones-Carson, and Ferric C. Fang
J Immunol 2004 172: 6202-6208. [Abstract] [Full Text] [PDF]  

Induction of HIV Immunity in the Genital Tract After Intranasal Delivery of a MVA Vector: Enhanced Immunogenicity After DNA Prime-Modified Vaccinia Virus Ankara Boost Immunization Schedule

M. Magdalena Gherardi, Eva Pérez-Jiménez, José Luis Nájera, and Mariano Esteban
J Immunol 2004 172: 6209-6220. [Abstract] [Full Text] [PDF]  

Immunological Characteristics Associated with the Protective Efficacy of Antibodies to Ricin

Massimo Maddaloni, Corrie Cooke, Royce Wilkinson, Audrey V. Stout, Leta Eng, and Seth H. Pincus
J Immunol 2004 172: 6221-6228. [Abstract] [Full Text] [PDF]  

Filaria-Induced Immune Evasion: Suppression by the Infective Stage of Brugia malayi at the Earliest Host-Parasite Interface

Roshanak Tolouei Semnani, Melissa Law, Joseph Kubofcik, and Thomas B. Nutman
J Immunol 2004 172: 6229-6238. [Abstract] [Full Text] [PDF]  

Visualizing the Viral Burden: Phenotypic and Functional Alterations of T Cells and APCs during Persistent Infection

Dirk Homann, Dorian B. McGavern, and Michael B. A. Oldstone
J Immunol 2004 172: 6239-6250. [Abstract] [Full Text] [PDF]  

Mycobacterium tuberculosis-Induced CXCR4 and Chemokine Expression Leads to Preferential X4 HIV-1 Replication in Human Macrophages

Yoshihiko Hoshino, Doris B. Tse, Gemma Rochford, Savita Prabhakar, Satomi Hoshino, Nishay Chitkara, Kenichi Kuwabara, Elbert Ching, Bindu Raju, Jeffrey A. Gold, William Borkowsky, William N. Rom, Richard Pine, and Michael Weiden
J Immunol 2004 172: 6251-6258. [Abstract] [Full Text] [PDF]  

IgA Class Switch Occurs in the Organized Nasopharynx- and Gut-Associated Lymphoid Tissue, but Not in the Diffuse Lamina Propria of Airways and Gut

Takashi Shikina, Takachika Hiroi, Kohichi Iwatani, Myoung Ho Jang, Satoshi Fukuyama, Manabu Tamura, Takeshi Kubo, Hiromichi Ishikawa, and Hiroshi Kiyono
J Immunol 2004 172: 6259-6264. [Abstract] [Full Text] [PDF]  

Cellular and Humoral Immunity against Vaccinia Virus Infection of Mice

Rong Xu, Aaron J. Johnson, Denny Liggitt, and Michael J. Bevan
J Immunol 2004 172: 6265-6271. [Abstract] [Full Text] [PDF]  

Mycobacterium tuberculosis Inhibits Macrophage Responses to IFN- through Myeloid Differentiation Factor 88-Dependent and -Independent Mechanisms

Sarah M. Fortune, Alejandra Solache, Alejandra Jaeger, Preston J. Hill, John T. Belisle, Barry R. Bloom, Eric J. Rubin, and Joel D. Ernst
J Immunol 2004 172: 6272-6280. [Abstract] [Full Text] [PDF]  

Dendritic Cells (DC) Activated by CpG DNA Ex Vivo Are Potent Inducers of Host Resistance to an Intracellular Pathogen That Is Independent of IL-12 Derived from the Immunizing DC

José R. Ramírez-Pineda, Anja Fröhlich, Christof Berberich, and Heidrun Moll
J Immunol 2004 172: 6281-6289. [Abstract] [Full Text] [PDF]  

Immunogenicity of Recombinant Adenovirus Serotype 35 Vaccine in the Presence of Pre-Existing Anti-Ad5 Immunity

Dan H. Barouch, Maria G. Pau, Jerome H. H. V. Custers, Wouter Koudstaal, Stefan Kostense, Menzo J. E. Havenga, Diana M. Truitt, Shawn M. Sumida, Michael G. Kishko, Janelle C. Arthur, Birgit Korioth-Schmitz, Michael H. Newberg, Darci A. Gorgone, Michelle A. Lifton, Dennis L. Panicali, Gary J. Nabel, Norman L. Letvin, and Jaap Goudsmit
J Immunol 2004 172: 6290-6297. [Abstract] [Full Text] [PDF]  

Mouse Strain Susceptibility to Trypanosome Infection: An Arginase-Dependent Effect

Sébastien Duleu, Philippe Vincendeau, Pierrette Courtois, Silla Semballa, Isabelle Lagroye, Sylvie Daulouède, Jean-Luc Boucher, Keith T. Wilson, Bernard Veyret, and Alain P. Gobert
J Immunol 2004 172: 6298-6303. [Abstract] [Full Text] [PDF]  

Dendritic Cells from Mice Neonatally Vaccinated with Modified Vaccinia Virus Ankara Transfer Resistance against Herpes Simplex Virus Type I to Naive One-Week-Old Mice

Marco Franchini, Hanspeter Hefti, Sabine Vollstedt, Bettina Glanzmann, Matthias Riesen, Mathias Ackermann, Paul Chaplin, Ken Shortman, and Mark Suter
J Immunol 2004 172: 6304-6312. [Abstract] [Full Text] [PDF]  

Viral FLIP Impairs Survival of Activated T Cells and Generation of CD8⁺ T Cell Memory

Zhengqi Wu, Margaret Roberts, Melissa Porter, Fabianne Walker, E. John Wherry, John Kelly, Massimo Gadina, Elisabeth M. Silva, George A. DosReis, Marcela F. Lopes, John O’Shea, Warren J. Leonard, Rafi Ahmed, and Richard M. Siegel
J Immunol 2004 172: 6313-6323. [Abstract] [Full Text] [PDF]  

Dual Role of TLR2 and Myeloid Differentiation Factor 88 in a Mouse Model of Invasive Group B Streptococcal Disease

Giuseppe Mancuso, Angelina Midiri, Concetta Beninati, Carmelo Biondo, Roberta Galbo, Shizuo Akira, Philipp Henneke, Douglas Golenbock, and Giuseppe Teti
J Immunol 2004 172: 6324-6329. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Augmentation of Chemotherapy-Induced Cytokine Production by Expression of the Platelet-Activating Factor Receptor in a Human Epithelial Carcinoma Cell Line

Marc Darst, Mohammed Al-Hassani, Tao Li, Qiaofang Yi, John M. Travers, Davina A. Lewis, and Jeffrey B. Travers
J Immunol 2004 172: 6330-6335. [Abstract] [Full Text] [PDF]  

Transient and Selective NF-B p65 Serine 536 Phosphorylation Induced by T Cell Costimulation Is Mediated by IB Kinase and Controls the Kinetics of p65 Nuclear Import

Ivan Mattioli, Andrea Sebald, Cyril Bucher, Roch-Philippe Charles, Hiroyasu Nakano, Takahiro Doi, Michael Kracht, and M. Lienhard Schmitz
J Immunol 2004 172: 6336-6344. [Abstract] [Full Text] [PDF]  

Intracellular Bacterial Infection-Induced IFN- Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN--STAT1 Signaling

Antonio Gigliotti Rothfuchs, Christian Trumstedt, Hans Wigzell, and Martin E. Rottenberg
J Immunol 2004 172: 6345-6353. [Abstract] [Full Text] [PDF]  

Studies of Congenic Lines in the Brown Norway Rat Model of Th2-Mediated Immunopathological Disorders Show That the Aurothiopropanol Sulfonate-Induced Immunological Disorder (Aiid3) Locus on Chromosome 9 Plays a Major Role Compared to Aiid2 on Chromosome 10

Magali Mas, Pierre Cavaillès, Céline Colacios, Jean-François Subra, Dominique Lagrange, Maryline Calise, Marie-Odile Christen, Philippe Druet, Lucette Pelletier, Dominique Gauguier, and Gilbert J. Fournié
J Immunol 2004 172: 6354-6361. [Abstract] [Full Text] [PDF]  

The Transmembrane CXC-Chemokine Ligand 16 Is Induced by IFN- and TNF- and Shed by the Activity of the Disintegrin-Like Metalloproteinase ADAM10

Soeren Abel, Christian Hundhausen, Rolf Mentlein, Alexander Schulte, Theo A. Berkhout, Neil Broadway, Dieter Hartmann, Radek Sedlacek, Sebastian Dietrich, Barbara Muetze, Bjoern Schuster, Karl-Josef Kallen, Paul Saftig, Stefan Rose-John, and Andreas Ludwig
J Immunol 2004 172: 6362-6372. [Abstract] [Full Text] [PDF]  

6-Phosphogluconate Dehydrogenase and Glucose-6-Phosphate Dehydrogenase Form a Supramolecular Complex in Human Neutrophils That Undergoes Retrograde Trafficking during Pregnancy

Andrei L. Kindzelskii, Tatsuya Ueki, Hitoshi Michibata, Tinnakorn Chaiworapongsa, Roberto Romero, and Howard R. Petty
J Immunol 2004 172: 6373-6381. [Abstract] [Full Text] [PDF]  

Inactivation of C5a Anaphylatoxin by a Peptide That Is Complementary to a Region of C5a

Emiko Fujita, Imre Farkas, William Campbell, Lajos Baranyi, Hidechika Okada, and Noriko Okada
J Immunol 2004 172: 6382-6387. [Abstract] [Full Text] [PDF]  

Ectopic CD40 Ligand Expression on B Cells Triggers Intestinal Inflammation

Takahiro Kawamura, Takanori Kanai, Taeko Dohi, Koji Uraushihara, Teruji Totsuka, Ryoichi Iiyama, Chikara Taneda, Motomi Yamazaki, Tetsuya Nakamura, Tetsuya Higuchi, Yuichi Aiba, Takeshi Tsubata, and Mamoru Watanabe
J Immunol 2004 172: 6388-6397. [Abstract] [Full Text] [PDF]  

Mast Cells, FcRI, and IL-13 Are Required for Development of Airway Hyperresponsiveness after Aerosolized Allergen Exposure in the Absence of Adjuvant

Christian Taube, Xudong Wei, Christina H. Swasey, Anthony Joetham, Simona Zarini, Tricia Lively, Katsuyuki Takeda, Joan Loader, Nobuaki Miyahara, Taku Kodama, Lenny D. Shultz, Debra D. Donaldson, Eckard H. Hamelmann, Azzeddine Dakhama, and Erwin W. Gelfand
J Immunol 2004 172: 6398-6406. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

The Functional Profile of Primary Human Antiviral CD8⁺ T Cell Effector Activity Is Dictated by Cognate Peptide Concentration

Michael R. Betts, David A. Price, Jason M. Brenchley, Karin Loré, F. Javier Guenaga, Anna Smed-Sorensen, David R. Ambrozak, Stephen A. Migueles, Mark Connors, Mario Roederer, Daniel C. Douek, and Richard A. Koup
J Immunol 2004 172: 6407-6417. [Abstract] [Full Text] [PDF]  

Attenuation of Experimental Autoimmune Encephalomyelitis and Nonimmune Demyelination by IFN- plus Vitamin B₁₂: Treatment to Modify Notch-1/Sonic Hedgehog Balance

Fabrizio G. Mastronardi, Weixian Min, Huimin Wang, Shawn Winer, Michael Dosch, Joan M. Boggs, and Mario A. Moscarello
J Immunol 2004 172: 6418-6426. [Abstract] [Full Text] [PDF]  

Generation and Regulation of Human Th1-Biased Immune Responses In Vivo: A Critical Role for IL-4 and IL-10

Alla Skapenko, Gerald U. Niedobitek, Joachim R. Kalden, Peter E. Lipsky, and Hendrik Schulze-Koops
J Immunol 2004 172: 6427-6434. [Abstract] [Full Text] [PDF]  

CD4⁺CD25^bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

Ismé M. de Kleer, Lucy R. Wedderburn, Leonie S. Taams, Alka Patel, Hemlata Varsani, Mark Klein, Wilco de Jager, Gisela Pugayung, Francesca Giannoni, Ger Rijkers, Salvatore Albani, Wietse Kuis, and Berent Prakken
J Immunol 2004 172: 6435-6443. [Abstract] [Full Text] [PDF]  

Xenobiotic-Induced Loss of Tolerance in Rabbits to the Mitochondrial Autoantigen of Primary Biliary Cirrhosis Is Reversible

Katsushi Amano, Patrick S. C. Leung, Qingchai Xu, Jan Marik, Chao Quan, Mark J. Kurth, Michael H. Nantz, Aftab A. Ansari, Kit S. Lam, Mikio Zeniya, Ross L. Coppel, and M. Eric Gershwin
J Immunol 2004 172: 6444-6452. [Abstract] [Full Text] [PDF]  

Antiviral Cytokines Induce Hepatic Expression of the Granzyme B Inhibitors, Proteinase Inhibitor 9 and Serine Proteinase Inhibitor 6

Mahmoud B. Barrie, Heather W. Stout, Marwan S. Abougergi, Bonnie C. Miller, and Dwain L. Thiele
J Immunol 2004 172: 6453-6459. [Abstract] [Full Text] [PDF]  

Lack of Galactose--1,3-Galactose Expression on Porcine Endothelial Cells Prevents Complement-Induced Lysis but Not Direct Xenogeneic NK Cytotoxicity

Bettina C. Baumann, Pietro Forte, Robert J. Hawley, Robert Rieben, Mårten K. J. Schneider, and Jörg D. Seebach
J Immunol 2004 172: 6460-6467. [Abstract] [Full Text] [PDF]  

Type I Regulatory T Cells Specific for Desmoglein 3 Are More Frequently Detected in Healthy Individuals than in Patients with Pemphigus Vulgaris

Christian Veldman, Annette Höhne, Detlef Dieckmann, Gerold Schuler, and Michael Hertl
J Immunol 2004 172: 6468-6475. [Abstract] [Full Text] [PDF]  

IFN- Priming Results in a Gain of Proinflammatory Function by IL-10: Implications for Systemic Lupus Erythematosus Pathogenesis

M. Nusrat Sharif, Ioannis Tassiulas, Yang Hu, Ingrid Mecklenbräuker, Alexander Tarakhovsky, and Lionel B. Ivashkiv
J Immunol 2004 172: 6476-6481. [Abstract] [Full Text] [PDF]  

The Novel Cyclophilin-Binding Drug Sanglifehrin A Specifically Affects Antigen Uptake Receptor Expression and Endocytic Capacity of Human Dendritic Cells

Andrea M. Woltman, Nicole Schlagwein, Sandra W. van der Kooij, and Cees van Kooten
J Immunol 2004 172: 6482-6489. [Abstract] [Full Text] [PDF]  

Molecular Characterization of Polygalacturonases as Grass Pollen-Specific Marker Allergens: Expulsion from Pollen via Submicronic Respirable Particles

Ines Swoboda, Monika Grote, Petra Verdino, Walter Keller, Mohan B. Singh, Nicole De Weerd, Wolfgang R. Sperr, Peter Valent, Nadja Balic, Rudolf Reichelt, Roland Suck, Helmut Fiebig, Rudolf Valenta, and Susanne Spitzauer
J Immunol 2004 172: 6490-6500. [Abstract] [Full Text] [PDF]  

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