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On the cover: Transgenic rabbits overexpressing an anti-inflammatory lipid mediator, lipoxin pathway are protected from periodontal destruction brought on as an unwanted side effect of oral inflammation and host defense, namely periodontitis. Each year periodontal disease affects ~ 80% of the population worldwide. The bone and teeth of a protected transgenic rabbit are shown. Serhan et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J. Immunol. 171:6856.