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On the cover: Side-view projection of leukocyte-endothelial interaction reconstructed from serial section confocal microscopy. Endothelial ICAM-1 (green) rapidly relocalized to newly formed microvilli-like membrane projections in response to binding LFA-1 (red) on leukocytes. These ICAM-1-enriched projections encircled the leukocytes extending up their sides, and clustered LFA-1 underneath into linear tracks. Colocalized ICAM-1 and LFA-1 appear yellow. Carman et al. Endothelial cells proactiveley form microvilli-like membrane projections upon intercellular adhesion molecule 1 engagement of leukocyte LFA-1. J. Immunol. 171:6135.
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