IN THIS ISSUE:

IN THIS ISSUE

J Immunol 2003 170: 4879-4880. [Full Text] [PDF]  

CUTTING EDGE:

Cutting Edge: The NK Cell Receptor 2B4 Augments Antigen-Specific T Cell Cytotoxicity Through CD48 Ligation on Neighboring T Cells

Kyung-Mi Lee, Sadhna Bhawan, Takashi Majima, Hairong Wei, Michael I. Nishimura, Hideo Yagita, and Vinay Kumar
J Immunol 2003 170: 4881-4885. [Abstract] [Full Text] [PDF]  

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

Atsunobu Takeda, Shinjiro Hamano, Atsushi Yamanaka, Toshikatsu Hanada, Tatsuro Ishibashi, Tak W. Mak, Akihiko Yoshimura, and Hiroki Yoshida
J Immunol 2003 170: 4886-4890. [Abstract] [Full Text] [PDF]  

Cutting Edge: Dependence of TCR Antagonism on Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Activity

Neely E. Kilgore, Jenny D. Carter, Ulrike Lorenz, and Brian D. Evavold
J Immunol 2003 170: 4891-4895. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Environmental Chemical-Induced Pro/Pre-B Cell Apoptosis: Analysis of c-Myc, p27^Kip1, and p21^WAF1 Reveals a Death Pathway Distinct from Clonal Deletion

Heui-Young Ryu, Koren K. Mann, Jennifer J. Schlezinger, Brenda Jensen, and David H. Sherr
J Immunol 2003 170: 4897-4904. [Abstract] [Full Text] [PDF]  

Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells

Anna K. Nowak, Richard A. Lake, Amanda L. Marzo, Bernadette Scott, William R. Heath, Edward J. Collins, Jeffrey A. Frelinger, and Bruce W. S. Robinson
J Immunol 2003 170: 4905-4913. [Abstract] [Full Text] [PDF]  

Two Regions of Down-Regulation in the IgE-Mediated Signaling Pathway in Human Basophils

Donald MacGlashan, Jr.
J Immunol 2003 170: 4914-4925. [Abstract] [Full Text] [PDF]  

The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells

Lynn Corcoran, Isabel Ferrero, David Vremec, Karen Lucas, Jason Waithman, Meredith O’Keeffe, Li Wu, Anne Wilson, and Ken Shortman
J Immunol 2003 170: 4926-4932. [Abstract] [Full Text] [PDF]  

Regulation of CD8⁺ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host

Vladimir P. Badovinac, Kelly A. Nordyke Messingham, Sara E. Hamilton, and John T. Harty
J Immunol 2003 170: 4933-4942. [Abstract] [Full Text] [PDF]  

Prostaglandin D₂ Affects the Maturation of Human Monocyte-Derived Dendritic Cells: Consequence on the Polarization of Naive Th Cells

Philippe Gosset, Fabrice Bureau, Veronique Angeli, Muriel Pichavant, Christelle Faveeuw, André-Bernard Tonnel, and François Trottein
J Immunol 2003 170: 4943-4952. [Abstract] [Full Text] [PDF]  

Differential Roles of CB1 and CB2 Cannabinoid Receptors in Mast Cells

Maria-Teresa Samson, Andrea Small-Howard, Lori M. N. Shimoda, Murielle Koblan-Huberson, Alexander J. Stokes, and Helen Turner
J Immunol 2003 170: 4953-4962. [Abstract] [Full Text] [PDF]  

Stochastic Model of T Cell Proliferation: A Calculus Revealing IL-2 Regulation of Precursor Frequencies, Cell Cycle Time, and Survival

Elissa K. Deenick, Amanda V. Gett, and Philip D. Hodgkin
J Immunol 2003 170: 4963-4972. [Abstract] [Full Text] [PDF]  

Active Form of Notch Members Can Enforce T Lymphopoiesis on Lymphoid Progenitors in the Monolayer Culture Specific for B Cell Development

Katsuto Hozumi, Natsumi Abe, Shigeru Chiba, Hisamaru Hirai, and Sonoko Habu
J Immunol 2003 170: 4973-4979. [Abstract] [Full Text] [PDF]  

Histone Deacetylation, But Not Hypermethylation, Modifies Class II Transactivator and MHC Class II Gene Expression in Squamous Cell Carcinomas

Takayuki Kanaseki, Hideyuki Ikeda, Yukio Takamura, Minoru Toyota, Yoshihiko Hirohashi, Takashi Tokino, Tetsuo Himi, and Noriyuki Sato
J Immunol 2003 170: 4980-4985. [Abstract] [Full Text] [PDF]  

Differential Control of Cell Cycle, Proliferation, and Survival of Primary T Lymphocytes by Purine and Pyrimidine Nucleotides

Laurence Quéméneur, Luc-Marie Gerland, Monique Flacher, Martine Ffrench, Jean-Pierre Revillard, and Laurent Genestier
J Immunol 2003 170: 4986-4995. [Abstract] [Full Text] [PDF]  

Mechanisms of Accelerated Immune-Mediated Diabetes Resulting from Islet Cell Expression of a Fas Ligand Transgene

Diego G. Silva, Nikolai Petrovsky, Luis Socha, Robyn Slattery, Paul Gatenby, and Brett Charlton
J Immunol 2003 170: 4996-5002. [Abstract] [Full Text] [PDF]  

IL-18 and IL-12 Signal Through the NF-B Pathway to Induce NK-1R Expression on T Cells

Joel V. Weinstock, Arthur Blum, Ahmed Metwali, David Elliott, and Razvan Arsenescu
J Immunol 2003 170: 5003-5007. [Abstract] [Full Text] [PDF]  

Superantigen-Induced Regulatory T Cells Display Different Suppressive Functions in the Presence or Absence of Natural CD4⁺CD25⁺ Regulatory T Cells In Vivo

Susanna Grundström, Lukas Cederbom, Anette Sundstedt, Peter Scheipers, and Fredrik Ivars
J Immunol 2003 170: 5008-5017. [Abstract] [Full Text] [PDF]  

IL-15 Promotes the Survival of Naive and Memory Phenotype CD8⁺ T Cells

Marion Berard, Katja Brandt, Silvia Bulfone Paus, and David F. Tough
J Immunol 2003 170: 5018-5026. [Abstract] [Full Text] [PDF]  

A Peptide from Heat Shock Protein 60 Is the Dominant Peptide Bound To Qa-1 in the Absence of the MHC Class Ia Leader Sequence Peptide Qdm

Adrian Davies, Suzanne Kalb, Bitao Liang, Carla J. Aldrich, François A. Lemonnier, Hong Jiang, Robert Cotter, and Mark J. Soloski
J Immunol 2003 170: 5027-5033. [Abstract] [Full Text] [PDF]  

Extracellular Matrix Conditions T Cells for Adhesion to Tissue Interstitium

Kimberly A. Krivacic and Alan D. Levine
J Immunol 2003 170: 5034-5044. [Abstract] [Full Text] [PDF]  

Mast Cells Express Novel Functional IL-15 Receptor Isoforms

Elena Bulanova, Vadim Budagian, Zane Orinska, Hans Krause, Ralf Paus, and Silvia Bulfone-Paus
J Immunol 2003 170: 5045-5055. [Abstract] [Full Text] [PDF]  

Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

Cynthia Mueller and Avery August
J Immunol 2003 170: 5056-5063. [Abstract] [Full Text] [PDF]  

Nitric Oxide-Independent CTL Suppression during Tumor Progression: Association with Arginase-Producing (M2) Myeloid Cells

Yuanqing Liu, Jo A. Van Ginderachter, Lea Brys, Patrick De Baetselier, Geert Raes, and Anja B. Geldhof
J Immunol 2003 170: 5064-5074. [Abstract] [Full Text] [PDF]  

Early IL-2 Production by Mouse Dendritic Cells Is the Result of Microbial-Induced Priming

Francesca Granucci, Sonia Feau, Véronique Angeli, François Trottein, and Paola Ricciardi-Castagnoli
J Immunol 2003 170: 5075-5081. [Abstract] [Full Text] [PDF]  

TNF Enhances CD4⁺ T Cell Alloproliferation, IFN- Responses, and Intestinal Graft-Versus-Host Disease by IL-12-Independent Mechanisms

Geri R. Brown, Edward L. Lee, and Dwain L. Thiele
J Immunol 2003 170: 5082-5088. [Abstract] [Full Text] [PDF]  

A Subset of Human Dendritic Cells in the T Cell Area of Mucosa-Associated Lymphoid Tissue with a High Potential to Produce TNF-

Annegret de Baey, Ines Mende, Gustavo Baretton, Axel Greiner, Wolfgang H. Hartl, Patrick A. Baeuerle, and Helmut M. Diepolder
J Immunol 2003 170: 5089-5094. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Repertoire Shift in the Humoral Response to Phosphocholine-Keyhole Limpet Hemocyanin: V_H Somatic Mutation in Germinal Center B Cells Impairs T15 Ig Function

Gregory D. Wiens, McKay Brown, and Marvin B. Rittenberg
J Immunol 2003 170: 5095-5102. [Abstract] [Full Text] [PDF]  

Prevalent Role of TCR -Chain in the Selection of the Preimmune Repertoire Specific for a Human Tumor-Associated Self-Antigen

Pierre-Yves Dietrich, Frédérique-Anne Le Gal, Valérie Dutoit, Mikäel J. Pittet, Lydie Trautman, Alfred Zippelius, Isabelle Cognet, Valérie Widmer, Paul R. Walker, Olivier Michielin, Philippe Guillaume, Thierry Connerotte, Francine Jotereau, Pierre G. Coulie, Pedro Romero, Jean-Charles Cerottini, Marc Bonneville, and Danila Valmori
J Immunol 2003 170: 5103-5109. [Abstract] [Full Text] [PDF]  

Decreased Binding of Peptides-MHC Class I (pMHC) Multimeric Complexes to CD8 Affects Their Binding Avidity for the TCR But Does Not Significantly Impact on pMHC/TCR Dissociation Rate

Valérie Dutoit, Philippe Guillaume, Maha Ayyoub, Charles S. Hesdorffer, Immanuel F. Luescher, and Danila Valmori
J Immunol 2003 170: 5110-5117. [Abstract] [Full Text] [PDF]  

Molecular Identification and Functional Expression of µ₃, a Novel Alternatively Spliced Variant of the Human µ Opiate Receptor Gene

Patrick Cadet, Kirk J. Mantione, and George B. Stefano
J Immunol 2003 170: 5118-5123. [Abstract] [Full Text] [PDF]  

DNA Methylation and Chromatin Structure Regulate T Cell Perforin Gene Expression

Qianjin Lu, Ailing Wu, Donna Ray, Chun Deng, John Attwood, Samir Hanash, Matthew Pipkin, Mathias Lichtenheld, and Bruce Richardson
J Immunol 2003 170: 5124-5132. [Abstract] [Full Text] [PDF]  

The H4^b Minor Histocompatibility Antigen Is Caused by a Combination of Genetically Determined and Posttranslational Modifications

Rajwardhan Yadav, Yoshitaka Yoshimura, Alina Boesteanu, Gregory J. Christianson, Wilfred U. Ajayi, R. Shashidharamurthy, Aleksandar K. Stanic, Derry C. Roopenian, and Sebastian Joyce
J Immunol 2003 170: 5133-5142. [Abstract] [Full Text] [PDF]  

Selective Regulation of Mature IgG1 Transcription by CD86 and ₂-Adrenergic Receptor Stimulation

Joseph R. Podojil and Virginia M. Sanders
J Immunol 2003 170: 5143-5151. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility to Leishmania major

Nancy Noben-Trauth, Rosalia Lira, Hisashi Nagase, William E. Paul, and David L. Sacks
J Immunol 2003 170: 5152-5158. [Abstract] [Full Text] [PDF]  

Toll-Like Receptor 2 (TLR2) and TLR9 Signaling Results in HIV-Long Terminal Repeat Trans-Activation and HIV Replication in HIV-1 Transgenic Mouse Spleen Cells: Implications of Simultaneous Activation of TLRs on HIV Replication

Ozlem Equils, Marco L. Schito, Hiase Karahashi, Zeynep Madak, Ayse Yarali, Kathrin S. Michelsen, Alan Sher, and Moshe Arditi
J Immunol 2003 170: 5159-5164. [Abstract] [Full Text] [PDF]  

The Toll-Like Receptor 5 Stimulus Bacterial Flagellin Induces Maturation and Chemokine Production in Human Dendritic Cells

Terry K. Means, Fumitaka Hayashi, Kelly D. Smith, Alan Aderem, and Andrew D. Luster
J Immunol 2003 170: 5165-5175. [Abstract] [Full Text] [PDF]  

The Induction of HIV Gag-Specific CD8⁺ T Cells in the Spleen and Gut-Associated Lymphoid Tissue by Parenteral or Mucosal Immunization with Recombinant Listeria monocytogenes HIV Gag

Christian Peters, Xiaohui Peng, Dennis Douven, Zhen-Kun Pan, and Yvonne Paterson
J Immunol 2003 170: 5176-5187. [Abstract] [Full Text] [PDF]  

A Single Heteroclitic Epitope Determines Cancer Immunity After Xenogeneic DNA Immunization Against a Tumor Differentiation Antigen

Jason S. Gold, Cristina R. Ferrone, Jose A. Guevara-Patiño, William G. Hawkins, Ruben Dyall, Manuel E. Engelhorn, Jedd D. Wolchok, Jonathan J. Lewis, and Alan N. Houghton
J Immunol 2003 170: 5188-5194. [Abstract] [Full Text] [PDF]  

Monocyte-Derived Dendritic Cells Generated After a Short-Term Culture with IFN- and Granulocyte-Macrophage Colony-Stimulating Factor Stimulate a Potent Epstein-Barr Virus-Specific CD8⁺ T Cell Response

Laura Santodonato, Giuseppina D’Agostino, Roberto Nisini, Sabrina Mariotti, Domenica M. Monque, Massimo Spada, Laura Lattanzi, Maria Paola Perrone, Mauro Andreotti, Filippo Belardelli, and Maria Ferrantini
J Immunol 2003 170: 5195-5202. [Abstract] [Full Text] [PDF]  

Cumulative Toll-Like Receptor Activation in Human Macrophages Treated with Whole Bacteria

Gerard J. Nau, Ann Schlesinger, Joan F. L. Richmond, and Richard A. Young
J Immunol 2003 170: 5203-5209. [Abstract] [Full Text] [PDF]  

The Lymphotoxin Receptor Is Critically Involved in Controlling Infections with the Intracellular Pathogens Mycobacterium tuberculosis and Listeria monocytogenes

Stefan Ehlers, Christoph Hölscher, Stefanie Scheu, Christine Tertilt, Thomas Hehlgans, Johanna Suwinski, Robert Endres, and Klaus Pfeffer
J Immunol 2003 170: 5210-5218. [Abstract] [Full Text] [PDF]  

Macrophages Restrict Pseudomonas aeruginosa Growth, Regulate Polymorphonuclear Neutrophil Influx, and Balance Pro- and Anti-Inflammatory Cytokines in BALB/c Mice

Sharon A. McClellan, Xi Huang, Ronald P. Barrett, Nico van Rooijen, and Linda D. Hazlett
J Immunol 2003 170: 5219-5227. [Abstract] [Full Text] [PDF]  

Neutrophilia in LFA-1-Deficient Mice Confers Resistance to Listeriosis: Possible Contribution of Granulocyte-Colony-Stimulating Factor and IL-17

Mamiko Miyamoto, Masashi Emoto, Yoshiko Emoto, Volker Brinkmann, Izumi Yoshizawa, Peter Seiler, Peter Aichele, Eiji Kita, and Stefan H. E. Kaufmann
J Immunol 2003 170: 5228-5234. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Chemotactic Factor-Induced Recruitment and Activation of Tec Family Kinases in Human Neutrophils. II. Effects of LFM-A13, a Specific Btk Inhibitor

Caroline Gilbert, Sylvain Levasseur, Philippe Desaulniers, Andrée-Anne Dusseault, Nathalie Thibault, Sylvain G. Bourgoin, and Paul H. Naccache
J Immunol 2003 170: 5235-5243. [Abstract] [Full Text] [PDF]  

Duffy Antigen Facilitates Movement of Chemokine Across the Endothelium In Vitro and Promotes Neutrophil Transmigration In Vitro and In Vivo

Janet S. Lee, Charles W. Frevert, Mark M. Wurfel, Stephen C. Peiper, Venus A. Wong, Kimberley K. Ballman, John T. Ruzinski, Johng S. Rhim, Thomas R. Martin, and Richard B. Goodman
J Immunol 2003 170: 5244-5251. [Abstract] [Full Text] [PDF]  

C-C Chemokine Ligand 2/Monocyte Chemoattractant Protein-1 Directly Inhibits NKT Cell IL-4 Production and Is Hepatoprotective in T Cell-Mediated Hepatitis in the Mouse

Maureen N. Ajuebor, Cory M. Hogaboam, Tai Le, and Mark G. Swain
J Immunol 2003 170: 5252-5259. [Abstract] [Full Text] [PDF]  

Different Modes of IL-10 and TGF- to Inhibit Cytokine-Dependent IFN- Production: Consequences for Reversal of Lipopolysaccharide Desensitization

Martina Schröder, Christian Meisel, Katharina Buhl, Nina Profanter, Nadine Sievert, Hans-Dieter Volk, and Gerald Grütz
J Immunol 2003 170: 5260-5267. [Abstract] [Full Text] [PDF]  

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

Ian Sabroe, Lynne R. Prince, Elizabeth C. Jones, Malcolm J. Horsburgh, Simon J. Foster, Stefanie N. Vogel, Steven K. Dower, and Moira K. B. Whyte
J Immunol 2003 170: 5268-5275. [Abstract] [Full Text] [PDF]  

Calcium-Independent Phospholipase A₂ Is Required for Lysozyme Secretion in U937 Promonocytes

María A. Balboa, Yolanda Sáez, and Jesús Balsinde
J Immunol 2003 170: 5276-5280. [Abstract] [Full Text] [PDF]  

Amyloid Peptide-Induced Cytokine and Chemokine Expression in THP-1 Monocytes Is Blocked by Small Inhibitory RNA Duplexes for Early Growth Response-1 Messenger RNA

Ranjit K. Giri, Suresh K. Selvaraj, and Vijay K. Kalra
J Immunol 2003 170: 5281-5294. [Abstract] [Full Text] [PDF]  

Peroxisome Proliferator-Activated Receptor Inhibits the Migration of Dendritic Cells: Consequences for the Immune Response

Véronique Angeli, Hamida Hammad, Bart Staels, Monique Capron, Bart N. Lambrecht, and François Trottein
J Immunol 2003 170: 5295-5301. [Abstract] [Full Text] [PDF]  

Akt Phosphorylates p47^phox and Mediates Respiratory Burst Activity in Human Neutrophils

Qingdan Chen, David W. Powell, Madhavi J. Rane, Saurabh Singh, Waseem Butt, Jon B. Klein, and Kenneth R. McLeish
J Immunol 2003 170: 5302-5308. [Abstract] [Full Text] [PDF]  

Expression and Production of the CXC Chemokine Growth-Related Oncogene- by Human Eosinophils

Terese Persson-Dajotoy, Pia Andersson, Anders Bjartell, Jero Calafat, and Arne Egesten
J Immunol 2003 170: 5309-5316. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Hybrids of Dendritic Cells and Tumor Cells Generated by Electrofusion Simultaneously Present Immunodominant Epitopes from Multiple Human Tumor-Associated Antigens in the Context of MHC Class I and Class II Molecules

Maria R. Parkhurst, Cormac DePan, John P. Riley, Steven A. Rosenberg, and Suyu Shu
J Immunol 2003 170: 5317-5325. [Abstract] [Full Text] [PDF]  

Immunization with a Xenobiotic 6-Bromohexanoate Bovine Serum Albumin Conjugate Induces Antimitochondrial Antibodies

Patrick S. C. Leung, Chao Quan, Ogyi Park, Judy Van de Water, Mark J. Kurth, Michael H. Nantz, Aftab A. Ansari, Ross L. Coppel, Kit S. Lam, and M. Eric Gershwin
J Immunol 2003 170: 5326-5332. [Abstract] [Full Text] [PDF]  

CORRECTION:

CORRECTION

J Immunol 2003 170: 5333. [Full Text] [PDF]  

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