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On the Cover: Effect of IL-1 on actin ring formation of pOCs.Src +/? pOCs were plated on Vn (20 µg/ml) (A--H)- or PL (50 µg/ml) (I)-coated dishes in the absence of serum. After culture for 60 min, cells were treated with IL-1 (10 ng/ml) for 0 (A, B, and I), 5 (C and D), 15 (E and F), 30 (G), and 60 (H) min. Cell were fixed and stained for tartrateresistant acid phosphatase (A, C, E, and I) or F-actin (B, D, F, G, and H). Bar = 20 µm. (Figure 1 from Nakamura, I., Y. Kadono, H. Takayanagi, E. Jimi, T. Miyazaki, H. Oda, K. Nakamura, S. Tanaka, G. A. Rodan, and L. T. Duong. IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex. J. Immunol. 168:5103.)
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