CUTTING EDGE:

Cutting Edge: Recombinant Adenoviruses Induce CD8 T Cell Responses to an Inserted Protein Whose Expression Is Limited to Nonimmune Cells

Shiv A. Prasad, Christopher C. Norbury, Weisan Chen, Jack R. Bennink, and Jonathan W. Yewdell
J Immunol 2001 166: 4809-4812. [Abstract] [Full Text] [PDF]  

Cutting Edge: Eotaxin Elicits Rapid Vesicular Transport-Mediated Release of Preformed IL-4 from Human Eosinophils

Christianne Bandeira-Melo, Kumiya Sugiyama, Lesley J. Woods, and Peter F. Weller
J Immunol 2001 166: 4813-4817. [Abstract] [Full Text] [PDF]  

Cutting Edge: Characterization of Allorestricted and Peptide-Selective Alloreactive T Cells Using HLA-Tetramer Selection

Arnaud Moris, Volker Teichgräber, Laurent Gauthier, Hans-Jörg Bühring, and Hans-Georg Rammensee
J Immunol 2001 166: 4818-4821. [Abstract] [Full Text] [PDF]  

Cutting Edge: Evidence for a Signaling Partnership Between Urokinase Receptors (CD87) and L-Selectin (CD62L) in Human Polymorphonuclear Neutrophils

Robert G. Sitrin, Pauline M. Pan, R. Alexander Blackwood, Jibiao Huang, and Howard R. Petty
J Immunol 2001 166: 4822-4825. [Abstract] [Full Text] [PDF]  

Cutting Edge: Telomerase Activation in Human T Lymphocytes Does Not Require Increase in Telomerase Reverse Transcriptase (hTERT) Protein But Is Associated with hTERT Phosphorylation and Nuclear Translocation

Kebin Liu, Richard J. Hodes, and Nan-ping Weng
J Immunol 2001 166: 4826-4830. [Abstract] [Full Text] [PDF]  

Cutting Edge: The Wiskott-Aldrich Syndrome Protein Is Required for Efficient Phagocytosis of Apoptotic Cells

Yann Leverrier, Roberto Lorenzi, Michael P. Blundell, Paul Brickell, Christine Kinnon, Anne J. Ridley, and Adrian J. Thrasher
J Immunol 2001 166: 4831-4834. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

A CCR5-Dependent Novel Mechanism for Type 1 HIV gp120 Induced Loss of Macrophage Cell Surface CD4

Tim J. Hewson, James J. Logie, Peter Simmonds, and Sarah E. M. Howie
J Immunol 2001 166: 4835-4842. [Abstract] [Full Text] [PDF]  

The Role of Dendritic Cells, B Cells, and M Cells in Gut-Oriented Immune Responses

Oral Alpan, Gregory Rudomen, and Polly Matzinger
J Immunol 2001 166: 4843-4852. [Abstract] [Full Text] [PDF]  

Transgenic Expression of IL-10 in T Cells Facilitates Development of Experimental Myasthenia Gravis

Norma S. Ostlie, Peter I. Karachunski, Wei Wang, Cristina Monfardini, Mitchell Kronenberg, and Bianca M. Conti-Fine
J Immunol 2001 166: 4853-4862. [Abstract] [Full Text] [PDF]  

Suppression of IgE Responses in CD23-Transgenic Animals Is Due to Expression of CD23 on Nonlymphoid Cells

Margaret Payet-Jamroz, Shirley L. T. Helm, Jiuhua Wu, Michelle Kilmon, Mohamed Fakher, Aynur Basalp, John G. Tew, Andras K. Szakal, Nancy Noben-Trauth, and Daniel H. Conrad
J Immunol 2001 166: 4863-4869. [Abstract] [Full Text] [PDF]  

Coregulation of CXC Chemokine Receptor and CD4 Expression on T Lymphocytes During Allogeneic Activation

Lisa M. Ebert and Shaun R. McColl
J Immunol 2001 166: 4870-4878. [Abstract] [Full Text] [PDF]  

Acute Rejection in the Absence of Cognate Recognition of Allograft by T Cells

Michel Y. Braun, Isabelle Grandjean, Pascal Feunou, Livine Duban, Robert Kiss, Michel Goldman, and Olivier Lantz
J Immunol 2001 166: 4879-4883. [Abstract] [Full Text] [PDF]  

Unique Functions of CD11b⁺, CD8⁺, and Double-Negative Peyer’s Patch Dendritic Cells

Akiko Iwasaki and Brian L. Kelsall
J Immunol 2001 166: 4884-4890. [Abstract] [Full Text] [PDF]  

Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4

Anan Chuntharapai, Kelly Dodge, Katharine Grimmer, Kurt Schroeder, Scot A. Marsters, Hartmut Koeppen, Avi Ashkenazi, and K. Jin Kim
J Immunol 2001 166: 4891-4898. [Abstract] [Full Text] [PDF]  

Antibody Binding to a Conformation-Dependent Epitope Induces L-Selectin Association with the Detergent-Resistant Cytoskeleton

Jeff G. Leid, Douglas A. Steeber, Thomas F. Tedder, and Mark A. Jutila
J Immunol 2001 166: 4899-4907. [Abstract] [Full Text] [PDF]  

CD80 Costimulation Is Required for Th2 Cell Cytokine Production But Not for Antigen-Specific Accumulation and Migration into the Lung

Nicola L. Harris, Melanie Prout, Robert J. Peach, Barbara Fazekas de St. Groth, and Franca Ronchese
J Immunol 2001 166: 4908-4914. [Abstract] [Full Text] [PDF]  

IL-12 Alone and in Synergy with IL-18 Inhibits Osteoclast Formation In Vitro

Nicole J. Horwood, Jan Elliott, T. John Martin, and Matthew T. Gillespie
J Immunol 2001 166: 4915-4921. [Abstract] [Full Text] [PDF]  

Modulation of Inhaled Antigen-Induced IgE Tolerance by Ongoing Th2 Responses in the Lung

Stephen D. Hurst, Brian W. P. Seymour, Tony Muchamuel, Viswanath P. Kurup, and Robert L. Coffman
J Immunol 2001 166: 4922-4930. [Abstract] [Full Text] [PDF]  

CD99 Signals Caspase-Independent T Cell Death

Rolf D. Pettersen, Ghislaine Bernard, Mette Kløvstad Olafsen, Monique Pourtein, and Sverre O. Lie
J Immunol 2001 166: 4931-4942. [Abstract] [Full Text] [PDF]  

ICOS Costimulation Requires IL-2 and Can Be Prevented by CTLA-4 Engagement

James L. Riley, Patrick J. Blair, John T. Musser, Ryo Abe, Katsunari Tezuka, Takashi Tsuji, and Carl H. June
J Immunol 2001 166: 4943-4948. [Abstract] [Full Text] [PDF]  

NF-B RelA (p65) Is Essential for TNF--Induced Fas Expression but Dispensable for Both TCR-Induced Expression and Activation-Induced Cell Death

Ye Zheng, Fateh Ouaaz, Peter Bruzzo, Veena Singh, Steve Gerondakis, and Amer A. Beg
J Immunol 2001 166: 4949-4957. [Abstract] [Full Text] [PDF]  

Migration and Maturation of Human Colonic Dendritic Cells

Sally J. Bell, Rachael Rigby, Nicholas English, Steven D. Mann, Stella C. Knight, Michael A. Kamm, and Andrew J. Stagg
J Immunol 2001 166: 4958-4967. [Abstract] [Full Text] [PDF]  

Adjuvanticity of ₂-Macroglobulin, an Independent Ligand for the Heat Shock Protein Receptor CD91

Robert J. Binder, David Karimeddini, and Pramod K. Srivastava
J Immunol 2001 166: 4968-4972. [Abstract] [Full Text] [PDF]  

The Activity of Immunoregulatory T Cells Mediating Active Tolerance Is Potentiated in Nonobese Diabetic Mice by an IL-4-Based Retroviral Gene Therapy

Ana Maria Yamamoto, Yuti Chernajovsky, Françoise Lepault, Osvaldo Podhajcer, Marc Feldmann, Jean-François Bach, and Lucienne Chatenoud
J Immunol 2001 166: 4973-4980. [Abstract] [Full Text] [PDF]  

Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis

Jian Zhang, Tamás Bárdos, Katalin Mikecz, Alison Finnegan, and Tibor T. Glant
J Immunol 2001 166: 4981-4986. [Abstract] [Full Text] [PDF]  

An HLA-DRB1-Derived Peptide Associated with Protection Against Rheumatoid Arthritis Is Naturally Processed by Human APCs

Alies Snijders, Diënne G. Elferink, Annemieke Geluk, A. Linda van der Zanden, Koen Vos, Geziena M. T. Schreuder, Ferdinand C. Breedveld, René R. P. de Vries, and Eric H. Zanelli
J Immunol 2001 166: 4987-4993. [Abstract] [Full Text] [PDF]  

Activating Ly-49 NK Receptors: Central Role in Cytokine and Chemokine Production

John R. Ortaldo, Earl W. Bere, Deborah Hodge, and Howard A. Young
J Immunol 2001 166: 4994-4999. [Abstract] [Full Text] [PDF]  

Bacterial CpG-DNA Triggers Activation and Maturation of Human CD11c^-, CD123⁺ Dendritic Cells

Marc Bauer, Vanessa Redecke, Joachim W. Ellwart, Barbara Scherer, Jean-Pierre Kremer, Hermann Wagner, and Grayson B. Lipford
J Immunol 2001 166: 5000-5007. [Abstract] [Full Text] [PDF]  

Murine Dendritic Cells Derived from Myeloid Progenitors of the Thymus Are Unable to Produce Bioactive IL-12p70

Catherine Martinon-Ego, Rolande Berthier, François Cretin, Véronique Collin, Anne-Marie Laharie, and Patrice N. Marche
J Immunol 2001 166: 5008-5017. [Abstract] [Full Text] [PDF]  

HLA-G2, -G3, and -G4 Isoforms Expressed as Nonmature Cell Surface Glycoproteins Inhibit NK and Antigen-Specific CTL Cytolysis

Béatrice Riteau, Nathalie Rouas-Freiss, Catherine Menier, Pascale Paul, Jean Dausset, and Edgardo D. Carosella
J Immunol 2001 166: 5018-5026. [Abstract] [Full Text] [PDF]  

CXCR-4 Desensitization Is Associated with Tissue Localization of Hemopoietic Progenitor Cells

Hongmei Shen, Tao Cheng, Ivona Olszak, Eduardo Garcia-Zepeda, Zhijian Lu, Steven Herrmann, Robert Fallon, Andrew D. Luster, and David T. Scadden
J Immunol 2001 166: 5027-5033. [Abstract] [Full Text] [PDF]  

Class I MHC-Binding Characteristics of the 129/J Ly49 Repertoire

Andrew P. Makrigiannis, Amanda T. Pau, Ali Saleh, Robin Winkler-Pickett, John R. Ortaldo, and Stephen K. Anderson
J Immunol 2001 166: 5034-5043. [Abstract] [Full Text] [PDF]  

Opposite Ability of Pre-TCR and TCR to Induce Apoptosis

Ann-Muriel Steff, Sébastien Trop, Mario Maira, Jacques Drouin, and Patrice Hugo
J Immunol 2001 166: 5044-5050. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line

Jürgen Bachl, Chris Carlson, Vanessa Gray-Schopfer, Mark Dessing, and Carina Olsson
J Immunol 2001 166: 5051-5057. [Abstract] [Full Text] [PDF]  

Identification of Novel Functional Regions Important for the Activity of HOXB7 in Mammalian Cells

Yifah Yaron, Jeanne K. McAdara, Maureen Lynch, Elizabeth Hughes, and Judith C. Gasson
J Immunol 2001 166: 5058-5067. [Abstract] [Full Text] [PDF]  

Interaction Properties of Human Mannan-Binding Lectin (MBL)-Associated Serine Proteases-1 and -2, MBL-Associated Protein 19, and MBL

Nicole M. Thielens, Sándor Cseh, Steffen Thiel, Thomas Vorup-Jensen, Véronique Rossi, Jens C. Jensenius, and Gérard J. Arlaud
J Immunol 2001 166: 5068-5077. [Abstract] [Full Text] [PDF]  

Clustering of Class I HLA Oligomers with CD8 and TCR: Three-Dimensional Models Based on Fluorescence Resonance Energy Transfer and Crystallographic Data

Rezso Gáspár, Jr., Péter Bagossi, László Bene, János Matkó, János Szöllosi, József Tozsér, László Fésüs, Thomas A. Waldmann, and Sándor Damjanovich
J Immunol 2001 166: 5078-5086. [Abstract] [Full Text] [PDF]  

Relaxed DM Requirements During Class II Peptide Loading and CD4⁺ T Cell Maturation in BALB/c Mice

Elizabeth K. Bikoff, Gordana Wutz, George A. Kenty, Chad H. Koonce, and Elizabeth J. Robertson
J Immunol 2001 166: 5087-5098. [Abstract] [Full Text] [PDF]  

Role of the Actin Cytoskeleton in T Cell Absorption and Internalization of Ligands from APC

Inkyu Hwang and Jonathan Sprent
J Immunol 2001 166: 5099-5107. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

LOX-1 Supports Adhesion of Gram-Positive and Gram-Negative Bacteria

Takeshi Shimaoka, Noriaki Kume, Manabu Minami, Kazutaka Hayashida, Tatsuya Sawamura, Toru Kita, and Shin Yonehara
J Immunol 2001 166: 5108-5114. [Abstract] [Full Text] [PDF]  

CD40 Signaling Converts a Minimally Immunogenic Antigen into a Potent Vaccine Against the Intracellular Pathogen Listeria monocytogenes

Michael S. Rolph and Stefan H. E. Kaufmann
J Immunol 2001 166: 5115-5121. [Abstract] [Full Text] [PDF]  

The Potency and Durability of DNA- and Protein-Based Vaccines Against Leishmania major Evaluated Using Low-Dose, Intradermal Challenge

Susana Méndez, Sanjay Gurunathan, Shaden Kamhawi, Yasmine Belkaid, Michael A. Moga, Yasir A. W. Skeiky, Antonio Campos-Neto, Steven Reed, Robert A. Seder, and David Sacks
J Immunol 2001 166: 5122-5128. [Abstract] [Full Text] [PDF]  

Fibronectin Binding Protein A of Staphylococcus aureus Can Mediate Human T Lymphocyte Adhesion and Coactivation

Yuko J. Miyamoto, Elisabeth R. Wann, Trent Fowler, Eric Duffield, Magnus Höök, and Bradley W. McIntyre
J Immunol 2001 166: 5129-5138. [Abstract] [Full Text] [PDF]  

Platelet-Activating Factor-Induced Early Activation of NF-B Plays a Crucial Role for Organ Clearance of Candida albicans

Jung Hwa Choi, Hyun Mi Ko, Jung-Woo Kim, Hern-Ku Lee, Sang Seop Han, Soon-Bai Chun, and Suhn Young Im
J Immunol 2001 166: 5139-5144. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Expression Cloning of the STRL33/BONZO/TYMSTR Ligand Reveals Elements of CC, CXC, and CX3C Chemokines

Alyson Wilbanks, Susan Carr Zondlo, Kristine Murphy, Simona Mak, Dulce Soler, Patricia Langdon, David P. Andrew, Lijun Wu, and Michael Briskin
J Immunol 2001 166: 5145-5154. [Abstract] [Full Text] [PDF]  

N-Acetylglucosamine Prevents IL-1-Mediated Activation of Human Chondrocytes

Alexander R. Shikhman, Klaus Kuhn, Nada Alaaeddine, and Martin Lotz
J Immunol 2001 166: 5155-5160. [Abstract] [Full Text] [PDF]  

Induction of Cross-Tolerance by Lipopolysaccharide and Highly Purified Lipoteichoic Acid Via Different Toll-Like Receptors Independent of Paracrine Mediators

Martin D. Lehner, Siegfried Morath, Kathrin S. Michelsen, Ralf R. Schumann, and Thomas Hartung
J Immunol 2001 166: 5161-5167. [Abstract] [Full Text] [PDF]  

Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis

Amy E. Juedes and Nancy H. Ruddle
J Immunol 2001 166: 5168-5175. [Abstract] [Full Text] [PDF]  

Production of Chemokines In Vivo in Response to Microbial Stimulation

Nicholas J. Coates and Shaun R. McColl
J Immunol 2001 166: 5176-5182. [Abstract] [Full Text] [PDF]  

Enhanced Airway Th2 Response After Allergen Challenge in Mice Deficient in CC Chemokine Receptor-2 (CCR2)

YongBok Kim, Sung-sang J. Sung, William A. Kuziel, Sanford Feldman, Shu Man Fu, and C. Edward Rose, Jr
J Immunol 2001 166: 5183-5192. [Abstract] [Full Text] [PDF]  

FcRIII-Mediated Production of TNF- Induces Immune Complex Alveolitis Independently of CXC Chemokine Generation

Nelli Chouchakova, Julia Skokowa, Ulrich Baumann, Thomas Tschernig, Karel M. H. Philippens, Bernhard Nieswandt, Reinhold E. Schmidt, and J. Engelbert Gessner
J Immunol 2001 166: 5193-5200. [Abstract] [Full Text] [PDF]  

Intracellular Pool of IL-10 Receptors in Specific Granules of Human Neutrophils: Differential Mobilization by Proinflammatory Mediators

Carole Elbim, Hélène Reglier, Michèle Fay, Charlotte Delarche, Valérie Andrieu, Jamel El Benna, and Marie-Anne Gougerot-Pocidalo
J Immunol 2001 166: 5201-5207. [Abstract] [Full Text] [PDF]  

Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury

Ren-Feng Guo, Alex B. Lentsch, Roscoe L. Warner, Markus Huber-Lang, J. Vidya Sarma, Tom Hlaing, Michael M. Shi, Nicholas W. Lukacs, and Peter A. Ward
J Immunol 2001 166: 5208-5218. [Abstract] [Full Text] [PDF]  

Therapeutic Effect of IL-13 Immunoneutralization During Chronic Experimental Fungal Asthma

Kate Blease, Claudia Jakubzick, John Westwick, Nicholas Lukacs, Steven L. Kunkel, and Cory M. Hogaboam
J Immunol 2001 166: 5219-5224. [Abstract] [Full Text] [PDF]  

Lethal Hepatitis After Gene Transfer of IL-4 in the Liver Is Independent of Immune Responses and Dependent on Apoptosis of Hepatocytes: A Rodent Model of IL-4-Induced Hepatitis

Cécile Guillot, Hélène Coathalem, Jérôme Chetritt, Anne David, Pedro Lowenstein, Emmanuelle Gilbert, Laurent Tesson, Nico van Rooijen, Maria Cristina Cuturi, Jean-Paul Soulillou, and Ignacio Anegon
J Immunol 2001 166: 5225-5235. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Highly Efficient Transduction of Human Monocyte-Derived Dendritic Cells with Subgroup B Fiber-Modified Adenovirus Vectors Enhances Transgene-Encoded Antigen Presentation to Cytotoxic T Cells

Delphine Rea, Menzo J. E. Havenga, Maayke van den Assem, Roger P. M. Sutmuller, Angelique Lemckert, Rob C. Hoeben, Abraham Bout, Cornelis J. M. Melief, and Rienk Offringa
J Immunol 2001 166: 5236-5244. [Abstract] [Full Text] [PDF]  

Spontaneous In Vivo Reversion of an Inherited Mutation in the Wiskott-Aldrich Syndrome

Tadashi Ariga, Tatsuro Kondoh, Koji Yamaguchi, Masafumi Yamada, Satoshi Sasaki, David L. Nelson, Hisami Ikeda, Kunihiko Kobayashi, Hiroyuki Moriuchi, and Yukio Sakiyama
J Immunol 2001 166: 5245-5249. [Abstract] [Full Text] [PDF]  

Targeting Antigen in Mature Dendritic Cells for Simultaneous Stimulation of CD4⁺ and CD8⁺ T Cells

Chiara Bonini, Steven P. Lee, Stan R. Riddell, and Philip D. Greenberg
J Immunol 2001 166: 5250-5257. [Abstract] [Full Text] [PDF]  

Posttransplant Administration of Donor Leukocytes Induces Long-Term Acceptance of Kidney or Liver Transplants by an Activation-Associated Immune Mechanism

Yiqun Yan, Suma Shastry, Craig Richards, Chuanmin Wang, David G. Bowen, Alexandra F. Sharland, Dorothy M. Painter, Geoffrey W. McCaughan, and G. Alex Bishop
J Immunol 2001 166: 5258-5264. [Abstract] [Full Text] [PDF]  

Intermolecular Antigen Spreading Occurs During the Preclinical Period of Human Type 1 Diabetes

Barbara Brooks-Worrell, Vivian H. Gersuk, Carla Greenbaum, and Jerry P. Palmer
J Immunol 2001 166: 5265-5270. [Abstract] [Full Text] [PDF]  

Identification of Epitope Regions Recognized by Tumor Inhibitory and Stimulatory Anti-ErbB-2 Monoclonal Antibodies: Implications for Vaccine Design

Yum L. Yip, Glenn Smith, Joachim Koch, Stefan Dübel, and Robyn L. Ward
J Immunol 2001 166: 5271-5278. [Abstract] [Full Text] [PDF]  

Anergy Induction by Dimeric TCR Ligands

Heiner Appel, Nilufer P. Seth, Laurent Gauthier, and Kai W. Wucherpfennig
J Immunol 2001 166: 5279-5285. [Abstract] [Full Text] [PDF]  

Molecular Mimicry in Lyme Arthritis Demonstrated at the Single Cell Level: LFA-1_L Is a Partial Agonist for Outer Surface Protein A-Reactive T Cells

Christina Trollmo, Abbie L. Meyer, Allen C. Steere, David A. Hafler, and Brigitte T. Huber
J Immunol 2001 166: 5286-5291. [Abstract] [Full Text] [PDF]  

Anti-Sm B Cell Differentiation in Ig Transgenic MRL/Mp-lpr/lpr Mice: Altered Differentiation and an Accelerated Response

Sandra Santulli-Marotto, Ye Qian, Stacy Ferguson, and Stephen H. Clarke
J Immunol 2001 166: 5292-5299. [Abstract] [Full Text] [PDF]  

T Cell Responses to HLA-A*0201-Restricted Peptides Derived from Human Fetoprotein

Lisa H. Butterfield, Wilson S. Meng, Andrew Koh, Charles M. Vollmer, Antoni Ribas, Vivian B. Dissette, Kym Faull, John A. Glaspy, William H. McBride, and James S. Economou
J Immunol 2001 166: 5300-5308. [Abstract] [Full Text] [PDF]  

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