CUTTING EDGE:

Cutting Edge: A Novel Function for the SLAP-130/FYB Adapter Protein in ß₁ Integrin Signaling and T Lymphocyte Migration

Anne J. Hunter, Nadine Ottoson, Nancy Boerth, Gary A. Koretzky, and Yoji Shimizu
J Immunol 2000 164: 1143-1147. [Abstract] [Full Text] [PDF]  

Cutting Edge: Cytolytic Effector Function in Human Circulating CD8⁺ T Cells Closely Correlates with CD56 Surface Expression

Mikaël J. Pittet, Daniel E. Speiser, Danila Valmori, Jean-Charles Cerottini, and Pedro Romero
J Immunol 2000 164: 1148-1152. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Differential Ca²⁺ Influx, K_Ca Channel Activity, and Ca²⁺ Clearance Distinguish Th1 and Th2 Lymphocytes

Christopher M. Fanger, Amber L. Neben, and Michael D. Cahalan
J Immunol 2000 164: 1153-1160. [Abstract] [Full Text] [PDF]  

Functional Consequences of the Developmental Arrest and Follicular Exclusion of Anti-Double-Stranded DNA B Cells

Laura Mandik-Nayak, Su-jean Seo, Ashlyn Eaton-Bassiri, David Allman, Richard R. Hardy, and Jan Erikson
J Immunol 2000 164: 1161-1168. [Abstract] [Full Text] [PDF]  

c-Src Mediates Mitogenic Signals and Associates with Cytoskeletal Proteins upon Vascular Endothelial Growth Factor Stimulation in Kaposi’s Sarcoma Cells

Neru Munshi, Jerome E. Groopman, Parkash S. Gill, and Ramesh K. Ganju
J Immunol 2000 164: 1169-1174. [Abstract] [Full Text] [PDF]  

IL-2 Unresponsiveness in Anergic CD4⁺ T Cells Is Due to Defective Signaling Through the Common -Chain of the IL-2 Receptor

Susanna Grundström, Mikael Dohlsten, and Anette Sundstedt
J Immunol 2000 164: 1175-1184. [Abstract] [Full Text] [PDF]  

Analysis of Immunomodulatory Activities of Aqueous Humor from Eyes of Mice with Experimental Autoimmune Uveitis

Kouichi Ohta, Barbara Wiggert, Satoru Yamagami, Andrew W. Taylor, and J. Wayne Streilein
J Immunol 2000 164: 1185-1192. [Abstract] [Full Text] [PDF]  

Blocking the Common -Chain of Cytokine Receptors Induces T Cell Apoptosis and Long-Term Islet Allograft Survival

Xian Chang Li, Azine Ima, Yongsheng Li, Xin Xiao Zheng, Thomas R. Malek, and Terry B. Strom
J Immunol 2000 164: 1193-1199. [Abstract] [Full Text] [PDF]  

Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Antigen-Induced Apoptosis of Mature T Lymphocytes by Inhibiting Fas Ligand Expression

Mario Delgado and Doina Ganea
J Immunol 2000 164: 1200-1210. [Abstract] [Full Text] [PDF]  

Protein Tyrosine Phosphatase Activity Is Required for IL-4 Induction of IL-4 Receptor -Chain

Hua Huang and William E. Paul
J Immunol 2000 164: 1211-1215. [Abstract] [Full Text] [PDF]  

Naive CD8⁺ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells

Bo Wang, Robert Maile, Roberta Greenwood, Edward J. Collins, and Jeffrey A. Frelinger
J Immunol 2000 164: 1216-1222. [Abstract] [Full Text] [PDF]  

CD72 Negatively Regulates Signaling Through the Antigen Receptor of B Cells

Takahiro Adachi, Chisato Wakabayashi, Toshinori Nakayama, Hidetaka Yakura, and Takeshi Tsubata
J Immunol 2000 164: 1223-1229. [Abstract] [Full Text] [PDF]  

Induction of CTL Responses by Simultaneous Administration of Liposomal Peptide Vaccine with Anti-CD40 and Anti-CTLA-4 mAb

Daisuke Ito, Kazumasa Ogasawara, Kazuya Iwabuchi, Yukio Inuyama, and Kazunori Onoé
J Immunol 2000 164: 1230-1235. [Abstract] [Full Text] [PDF]  

Phosphorylation of FADD/ MORT1 at Serine 194 and Association with a 70-kDa Cell Cycle-Regulated Protein Kinase

Carsten Scaffidi, Jörg Volkland, Ida Blomberg, Ingrid Hoffmann, Peter H. Krammer, and Marcus E. Peter
J Immunol 2000 164: 1236-1242. [Abstract] [Full Text] [PDF]  

Retrovirally Transduced Mouse Dendritic Cells Require CD4⁺ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

Stefan Schnell, James W. Young, Alan N. Houghton, and Michel Sadelain
J Immunol 2000 164: 1243-1250. [Abstract] [Full Text] [PDF]  

Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts

Yumi Yashiro-Ohtani, Xu-Yu Zhou, Kazuhito Toyo-oka, Xu-Guang Tai, Cheung-Seog Park, Toshiyuki Hamaoka, Ryo Abe, Kensuke Miyake, and Hiromi Fujiwara
J Immunol 2000 164: 1251-1259. [Abstract] [Full Text] [PDF]  

CD5 Costimulation Up-Regulates the Signaling to Extracellular Signal-Regulated Kinase Activation in CD4⁺CD8⁺ Thymocytes and Supports Their Differentiation to the CD4 Lineage

Xu-Yu Zhou, Yumi Yashiro-Ohtani, Kazuhito Toyo-oka, Cheung-Seog Park, Xu-Guang Tai, Toshiyuki Hamaoka, and Hiromi Fujiwara
J Immunol 2000 164: 1260-1268. [Abstract] [Full Text] [PDF]  

Tumors Promote Altered Maturation and Early Apoptosis of Monocyte-Derived Dendritic Cells

Sylvia M. Kiertscher, Jie Luo, Steven M. Dubinett, and Michael D. Roth
J Immunol 2000 164: 1269-1276. [Abstract] [Full Text] [PDF]  

Differential Regulation and Function of Fas Expression on Glial Cells

Sung Joong Lee, Tong Zhou, Chulhee Choi, Zheng Wang, and Etty N. Benveniste
J Immunol 2000 164: 1277-1285. [Abstract] [Full Text] [PDF]  

STAT1 Affects Lymphocyte Survival and Proliferation Partially Independent of Its Role Downstream of IFN-

Chien-Kuo Lee, Eric Smith, Ramon Gimeno, Rachel Gertner, and David E. Levy
J Immunol 2000 164: 1286-1292. [Abstract] [Full Text] [PDF]  

CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ckß-15 That Differ in Their Sensitivities to Ligand

Cheng-Rong Yu, Keith W. C. Peden, Marina B. Zaitseva, Hana Golding, and Joshua M. Farber
J Immunol 2000 164: 1293-1305. [Abstract] [Full Text] [PDF]  

T Cells Can Induce Somatic Mutation in B Cell Receptor-Engaged BL2 Burkitt’s Lymphoma Cells Independently of CD40-CD40 Ligand Interactions

Stéphane Denépoux, Nathalie Fournier, Catherine Péronne, Jacques Banchereau, and Serge Lebecque
J Immunol 2000 164: 1306-1313. [Abstract] [Full Text] [PDF]  

Oral Administration of Chitin Down-Regulates Serum IgE Levels and Lung Eosinophilia in the Allergic Mouse

Yoshimi Shibata, L. Ann Foster, John F. Bradfield, and Quentin N. Myrvik
J Immunol 2000 164: 1314-1321. [Abstract] [Full Text] [PDF]  

Annexin V Binds to Viable B Cells and Colocalizes with a Marker of Lipid Rafts upon B Cell Receptor Activation

Stacey R. Dillon, Marie Mancini, Antony Rosen, and Mark S. Schlissel
J Immunol 2000 164: 1322-1332. [Abstract] [Full Text] [PDF]  

Neuronal Fractalkine Expression in HIV-1 Encephalitis: Roles for Macrophage Recruitment and Neuroprotection in the Central Nervous System

Ning Tong, Seth W. Perry, Qing Zhang, Harold J. James, Huang Guo, Andrew Brooks, Harshawardhan Bal, Sandra A. Kinnear, Steven Fine, Leon G. Epstein, Daniel Dairaghi, Thomas J. Schall, Howard E. Gendelman, Stephen Dewhurst, Leroy R. Sharer, and Harris A. Gelbard2
J Immunol 2000 164: 1333-1339. [Abstract] [Full Text] [PDF]  

Cell-Mediated DNA Transport Between Distant Inflammatory Sites Following Intradermal DNA Immunization in the Presence of Adjuvant

Antonio La Cava, Rosario Billetta, Guido Gaietta, Dustan B. Bonnin, Stephen M. Baird, and Salvatore Albani
J Immunol 2000 164: 1340-1345. [Abstract] [Full Text] [PDF]  

Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo

Ajai Khanna, Adrian E. Morelli, Cuiping Zhong, Takuya Takayama, Lina Lu, and Angus W. Thomson
J Immunol 2000 164: 1346-1354. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Phosphatidylinositol 3-Kinase as a Mediator of TNF-Induced NF-B Activation

Shrikanth A. G. Reddy, Jianyi H. Huang, and Warren S.-L. Liao
J Immunol 2000 164: 1355-1363. [Abstract] [Full Text] [PDF]  

The Nuclear Receptor PPAR and Immunoregulation: PPAR Mediates Inhibition of Helper T Cell Responses

Robert B. Clark, David Bishop-Bailey, Tatiana Estrada-Hernandez, Timothy Hla, Lynn Puddington, and Steven J. Padula
J Immunol 2000 164: 1364-1371. [Abstract] [Full Text] [PDF]  

Identification of a Functional NF-B Site in the Platelet Endothelial Cell Adhesion Molecule-1 Promoter

Luisa M. Botella, Amaya Puig-Kröger, Nuria Almendro, Tilman Sánchez-Elsner, Eduardo Muñoz, Angel Corbí, and Carmelo Bernabéu
J Immunol 2000 164: 1372-1378. [Abstract] [Full Text] [PDF]  

Functional Role of the Noncatalytic Subunit of Complement C5 Convertase

Nenoo Rawal and Michael K. Pangburn
J Immunol 2000 164: 1379-1385. [Abstract] [Full Text] [PDF]  

Mamu-I: A Novel Primate MHC Class I B-Related Locus with Unusually Low Variability

Julie A. Urvater, Nel Otting, Jamie H. Loehrke, Richard Rudersdorf, Igor I. Slukvin, Marian S. Piekarczyk, Thaddeus G. Golos, Austin L. Hughes, Ronald E. Bontrop, and David I. Watkins
J Immunol 2000 164: 1386-1398. [Abstract] [Full Text] [PDF]  

Mucosa-Specific Targets for Regulation of IFN- Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN- Expression

Rivkah Gonsky, Richard L. Deem, Jay H. Bream, Doo Han Lee, Howard A. Young, and Stephan R. Targan
J Immunol 2000 164: 1399-1407. [Abstract] [Full Text] [PDF]  

Differences Among HIV-1 Variants in Their Ability to Elicit Secretion of TNF-

Kristen V. Khanna, Xiao-Fang Yu, David H. Ford, Lee Ratner, James K. Hildreth, and Richard B. Markham
J Immunol 2000 164: 1408-1415. [Abstract] [Full Text] [PDF]  

Analyses of TCR_B Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination

Euy Kyun Shin, Tonnie Rijkers, Albert Pastink, and Katheryn Meek
J Immunol 2000 164: 1416-1424. [Abstract] [Full Text] [PDF]  

A Bactericidal Monoclonal Antibody Elicits a Change in Its Antigen, OspB of Borrelia burgdorferi, That Can Be Detected by Limited Proteolysis

Laura I. Katona, Sahlu Ayalew, James L. Coleman, and Jorge L. Benach
J Immunol 2000 164: 1425-1431. [Abstract] [Full Text] [PDF]  

Structural Correlates of an Anticarcinoma Antibody: Identification of Specificity-Determining Residues (SDRs) and Development of a Minimally Immunogenic Antibody Variant by Retention of SDRs Only

Midori Tamura, Diane E. Milenic, Makoto Iwahashi, Eduardo Padlan, Jeffrey Schlom, and S. V. S. Kashmiri
J Immunol 2000 164: 1432-1441. [Abstract] [Full Text] [PDF]  

Porcine Lung Surfactant Protein D: Complementary DNA Cloning, Chromosomal Localization, and Tissue Distribution

Martin van Eijk, Henk P. Haagsman, Thomas Skinner, Alan Archibold, Kenneth B. M. Reid, and Peter R. Lawson
J Immunol 2000 164: 1442-1450. [Abstract] [Full Text] [PDF]  

Normal Isotype Switching in B Cells Lacking the Iµ Exon Splice Donor Site: Evidence for Multiple Iµ-Like Germline Transcripts

Igor I. Kuzin, Gregory D. Ugine, Dongming Wu, Fay Young, Jianzhu Chen, and Andrea Bottaro
J Immunol 2000 164: 1451-1457. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

IL-13 Is a Susceptibility Factor for Leishmania major Infection

David J. Matthews, Claire L. Emson, Grahame J. McKenzie, Helen E. Jolin, Jenefer M. Blackwell, and Andrew N. J. McKenzie
J Immunol 2000 164: 1458-1462. [Abstract] [Full Text] [PDF]  

Liver CD4^-CD8^- NK1.1⁺ TCRß Intermediate Cells Increase During Experimental Malaria Infection and Are Able to Exhibit Inhibitory Activity Against the Parasite Liver Stage In Vitro

Sylviane Pied, Jacques Roland, Anne Louise, Danièle Voegtle, Valérie Soulard, Dominique Mazier, and Pierre-André Cazenave
J Immunol 2000 164: 1463-1469. [Abstract] [Full Text] [PDF]  

The Neuronal Apoptosis Inhibitory Protein (Naip) Is Expressed in Macrophages and Is Modulated After Phagocytosis and During Intracellular Infection with Legionella pneumophila

Eduardo Diez, Zahra Yaraghi, Alex MacKenzie, and Philippe Gros
J Immunol 2000 164: 1470-1477. [Abstract] [Full Text] [PDF]  

Nitric Oxide Production by Human Intestinal Epithelial Cells and Competition for Arginine as Potential Determinants of Host Defense Against the Lumen-Dwelling Pathogen Giardia lamblia

Lars Eckmann, Fabrice Laurent, T. Dianne Langford, Michael L. Hetsko, Jennifer R. Smith, Martin F. Kagnoff, and Frances D. Gillin
J Immunol 2000 164: 1478-1487. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

C-C Chemokine Receptor 3 Antagonism by the ß-Chemokine Macrophage Inflammatory Protein 4, a Property Strongly Enhanced by an Amino-Terminal Alanine-Methionine Swap

Robert J. B. Nibbs, Theodora W. Salcedo, John D. M. Campbell, Xiao-Tao Yao, Yuling Li, Bernardetta Nardelli, Henrik S. Olsen, Tina S. Morris, Amanda E. I. Proudfoot, Vikram P. Patel, and Gerard J. Graham
J Immunol 2000 164: 1488-1497. [Abstract] [Full Text] [PDF]  

Inhibition of Mesangial Cell Nitric Oxide in MRL/lpr Mice by Prostaglandin J₂ and Proliferator Activation Receptor- Agonists

Christopher M. Reilly, James C. Oates, James A. Cook, Jason D. Morrow, Perry V. Halushka, and Gary S. Gilkeson
J Immunol 2000 164: 1498-1504. [Abstract] [Full Text] [PDF]  

A Soluble Recombinant Multimeric Anti-Rh(D) Single-Chain Fv/CR1 Molecule Restores the Immune Complex Binding Ability of CR1-Deficient Erythrocytes

S. Oudin, M. Tonye Libyh, D. Goossens, X. Dervillez, F. Philbert, B. Réveil, F. Bougy, T. Tabary, P. Rouger, D. Klatzmann, and J. H. M. Cohen
J Immunol 2000 164: 1505-1513. [Abstract] [Full Text] [PDF]  

C-Reactive Protein Binding to Murine Leukocytes Requires Fc Receptors

Mary-Pat Stein, Carolyn Mold, and Terry W. Du Clos
J Immunol 2000 164: 1514-1520. [Abstract] [Full Text] [PDF]  

Positive Regulation of c-Jun N-Terminal Kinase and TNF- Production But Not Histamine Release by SHP-1 in RBL-2H3 Mast Cells

Zhi-Hui Xie, Juan Zhang, and Reuben P. Siraganian
J Immunol 2000 164: 1521-1528. [Abstract] [Full Text] [PDF]  

Multispecific CD4⁺ T Cell Response to a Single 12-mer Epitope of the Immunodominant Heat-Shock Protein 60 of Yersinia enterocolitica in Yersinia-Triggered Reactive Arthritis: Overlap with the B27-Restricted CD8 Epitope, Functional Properties, and Epitope Presentation by Multiple DR Alleles

Andreas K. H. Mertz, Peihua Wu, Tiziana Sturniolo, Dieter Stoll, Martin Rudwaleit, Roland Lauster, Jürgen Braun, and Joachim Sieper
J Immunol 2000 164: 1529-1537. [Abstract] [Full Text] [PDF]  

Evidence for Local Eosinophil Differentiation Within Allergic Nasal Mucosa: Inhibition with Soluble IL-5 Receptor

Lisa Cameron, Pota Christodoulopoulos, Francois Lavigne, Yutaka Nakamura, David Eidelman, Alan McEuen, Andrew Walls, Jan Tavernier, Eleanor Minshall, Redwan Moqbel, and Qutayba Hamid
J Immunol 2000 164: 1538-1545. [Abstract] [Full Text] [PDF]  

Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils

Kiyoshi Takeyama, Karim Dabbagh, Jae Jeong Shim, Trang Dao-Pick, Iris F. Ueki, and Jay A. Nadel
J Immunol 2000 164: 1546-1552. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Highly Altered Vß Repertoire of T Cells Infiltrating Long-Term Rejected Kidney Allografts

Katia Gagne, Sophie Brouard, Magali Giral, Fabien Sebille, Anne Moreau, Marina Guillet, Jean-Denis Bignon, Berthe-Marie Imbert, Maria-Cristina Cuturi, and Jean-Paul Soulillou
J Immunol 2000 164: 1553-1563. [Abstract] [Full Text] [PDF]  

Evidence for Common Autoimmune Disease Genes Controlling Onset, Severity, and Chronicity Based on Experimental Models for Multiple Sclerosis and Rheumatoid Arthritis

Kristin Bergsteinsdottir, Hai-Tao Yang, Ulf Pettersson, and Rikard Holmdahl
J Immunol 2000 164: 1564-1568. [Abstract] [Full Text] [PDF]  

NZB Mice Exhibit a Primary T Cell Defect in Fetal Thymic Organ Culture

Yoshiko Hashimoto, Kenneth Dorshkind, Encarnacion Montecino-Rodriguez, Nobuhisa Taguchi, Leonard Shultz, and M. Eric Gershwin
J Immunol 2000 164: 1569-1575. [Abstract] [Full Text] [PDF]  

Viral IL-10 and Soluble TNF Receptor Act Synergistically to Inhibit Collagen-Induced Arthritis Following Adenovirus- Mediated Gene Transfer

Kwang-Nam Kim, Shohei Watanabe, Yuhe Ma, Sherry Thornton, Edward H. Giannini, and Raphael Hirsch
J Immunol 2000 164: 1576-1581. [Abstract] [Full Text] [PDF]  

Retrovirally Mediated IFN-ß Transduction of Macrophages Induces Resistance to HIV, Correlated with Up-Regulation of RANTES Production and Down-Regulation of C-C Chemokine Receptor-5 Expression

Isabelle Cremer, Vincent Vieillard, and Edward De Maeyer
J Immunol 2000 164: 1582-1587. [Abstract] [Full Text] [PDF]  

NF-B Modulates TNF- Production by Alveolar Macrophages in Asymptomatic HIV-Seropositive Individuals

Jean-Marie Mathys, Suzanne M. Melanson, Deborah J. Schiffer-Alberts, John P. A. Ioannidis, Henry Koziel, and Paul R. Skolnik
J Immunol 2000 164: 1588-1594. [Abstract] [Full Text] [PDF]  

Characteristics of Human IgA and IgM Genes Used by Plasma Cells in the Salivary Gland Resemble Those Used in Duodenum But Not Those Used in the Spleen

Deborah K. Dunn-Walters, Margaret Hackett, Laurent Boursier, Paul J. Ciclitira, Peter Morgan, Stephen J. Challacombe, and Jo Spencer
J Immunol 2000 164: 1595-1601. [Abstract] [Full Text] [PDF]  

HIV-1-Specific Mucosal CD8⁺ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi

Rupert Kaul, Francis A. Plummer, Joshua Kimani, Tao Dong, Peter Kiama, Timothy Rostron, Ephantus Njagi, Kelly S. MacDonald, Job J. Bwayo, Andrew J. McMichael, and Sarah L. Rowland-Jones
J Immunol 2000 164: 1602-1611. [Abstract] [Full Text] [PDF]  

Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES

Renate G. Nickel, Vincenzo Casolaro, Ulrich Wahn, Kirsten Beyer, Kathleen C. Barnes, Beverly S. Plunkett, Linda R. Freidhoff, Claudia Sengler, James R. Plitt, Robert P. Schleimer, Luis Caraballo, Raana P. Naidu, Paul N. Levett, Terri H. Beaty, and Shau-Ku Huang
J Immunol 2000 164: 1612-1616. [Abstract] [Full Text] [PDF]  

Delineation of a CpG Phosphorothioate Oligodeoxynucleotide for Activating Primate Immune Responses In Vitro and In Vivo

Gunther Hartmann, Risini D. Weeratna, Zuhair K. Ballas, Paul Payette, Sue Blackwell, Irma Suparto, Wendy L. Rasmussen, Marianella Waldschmidt, Dondin Sajuthi, Robert H. Purcell, Heather L. Davis, and Arthur M. Krieg
J Immunol 2000 164: 1617-1624. [Abstract] [Full Text] [PDF]  

Linear PADRE T Helper Epitope and Carbohydrate B Cell Epitope Conjugates Induce Specific High Titer IgG Antibody Responses

Jeff Alexander, Marie-France del Guercio, Ajesh Maewal, Lei Qiao, John Fikes, Robert W. Chesnut, James Paulson, David R. Bundle, Shawn DeFrees, and Alessandro Sette
J Immunol 2000 164: 1625-1633. [Abstract] [Full Text] [PDF]  

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