CUTTING EDGE:

Cutting Edge: Physical Interaction Between Dendritic Cells and Tumor Cells Results in an Immunogen That Induces Protective and Therapeutic Tumor Rejection

Christina M. Celluzzi and Louis D. Falo, Jr.
J Immunol 1998 160: 3081-3085. [Abstract] [Full Text] [PDF]  

Cutting Edge: Multiple Mechanisms of Peripheral T Cell Tolerance to the Fetal "Allograft"

Shi-Ping Jiang and Melanie S. Vacchio
J Immunol 1998 160: 3086-3090. [Abstract] [Full Text] [PDF]  

Cutting Edge: Dichotomous Effects of ß-Chemokines on HIV Replication in Monocytes and Monocyte-Derived Macrophages

Mark D. Kelly, Hassan M. Naif, Susan L. Adams, Anthony L. Cunningham, and Andrew R. Lloyd
J Immunol 1998 160: 3091-3095. [Abstract] [Full Text] [PDF]  

Cutting Edge: Human Myelomonocytic Cells Express an Inhibitory Receptor for Classical and Nonclassical MHC Class I Molecules

Marco Colonna, Jacqueline Samaridis, Marina Cella, Lena Angman, Rachel L. Allen, Chris A. O’Callaghan, Rod Dunbar, Graham S. Ogg, Vincenzo Cerundolo, and Antonius Rolink
J Immunol 1998 160: 3096-3100. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Distinct Peptide Loading Pathways for MHC Class II Molecules Associated with Alternative Ii Chain Isoforms

Elizabeth K. Bikoff, George Kenty, and Luc Van Kaer
J Immunol 1998 160: 3101-3110. [Abstract] [Full Text] [PDF]  

Intercellular and Intracellular Events Following the MHC-Unrestricted TCR Recognition of a Tumor-Specific Peptide Epitope on the Epithelial Antigen MUC1

Julie Magarian-Blander, Pawel Ciborowski, Shyuan Hsia, Simon C. Watkins, and Olivera J. Finn
J Immunol 1998 160: 3111-3120. [Abstract] [Full Text] [PDF]  

CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells

Jessica H. Roark, Se-Ho Park, Jayanthi Jayawardena, Uma Kavita, Michele Shannon, and Albert Bendelac
J Immunol 1998 160: 3121-3127. [Abstract] [Full Text] [PDF]  

Tissue-Specific Recognition of Mouse CD1 Molecules

Se-Ho Park, Jessica H. Roark, and Albert Bendelac
J Immunol 1998 160: 3128-3134. [Abstract] [Full Text] [PDF]  

Characterization of Signal Transduction Through the TCR- Chain Following T Cell Stimulation with Analogue Peptides of Type II Collagen 260–267

Bo Tang, Linda K. Myers, Edward F. Rosloniec, Karen B. Whittington, John M. Stuart, and Andrew H. Kang
J Immunol 1998 160: 3135-3142. [Abstract] [Full Text] [PDF]  

An In Vitro Model of T Cell Activation by Autologous Cytomegalovirus (CMV)-Infected Human Adult Endothelial Cells: Contribution of CMV-Enhanced Endothelial ICAM-1

W. James Waldman, Deborah A. Knight, and Emina H. Huang
J Immunol 1998 160: 3143-3151. [Abstract] [Full Text] [PDF]  

Overexpression of the p80 TNF Receptor Leads to TNF-Dependent Apoptosis, Nuclear Factor-B Activation, and c-Jun Kinase Activation

Valsala Haridas, Bryant G. Darnay, K. Natarajan, Renu Heller, and Bharat B. Aggarwal
J Immunol 1998 160: 3152-3162. [Abstract] [Full Text] [PDF]  

Superdominance Among Immunodominant H-2K^b-Restricted Epitopes and Reversal by Dendritic Cell-Mediated Antigen Delivery

Johan K. Sandberg, Per Grufman, Elisabeth Z. Wolpert, Lars Franksson, Benedict J. Chambers, and Klas Kärre
J Immunol 1998 160: 3163-3169. [Abstract] [Full Text] [PDF]  

Antibodies to Domains II and III of the IL-1 Receptor Accessory Protein Inhibit IL-1ß Activity But Not Binding: Regulation of IL-1 Responses Is Via Type I Receptor, Not the Accessory Protein

Do-Young Yoon and Charles A. Dinarello
J Immunol 1998 160: 3170-3179. [Abstract] [Full Text] [PDF]  

Purified MHC Class I and Peptide Complexes Activate Naive CD8⁺ T Cells Independently of the CD28/B7 and LFA-1/ICAM-1 Costimulatory Interactions

Julia S. Goldstein, Trina Chen, Mark Brunswick, Howard Mostowsky, and Steven Kozlowski
J Immunol 1998 160: 3180-3187. [Abstract] [Full Text] [PDF]  

Inhibitory and Stimulatory Effects of IL-10 on Human CD8⁺ T Cells

Hervé Groux, Mike Bigler, Jan E. de Vries, and Maria-Grazia Roncarolo
J Immunol 1998 160: 3188-3193. [Abstract] [Full Text] [PDF]  

Differential Susceptibility to Activation-Induced Apoptosis Among Peripheral Th1 Subsets: Correlation with Bcl-2 Expression and Consequences for AIDS Pathogenesis

Eric Ledru, Hervé Lecoeur, Sylvie Garcia, Thierry Debord, and Marie-Lise Gougeon
J Immunol 1998 160: 3194-3206. [Abstract] [Full Text] [PDF]  

Discoordinate Surface Expression of IFN--Induced HLA Class II Proteins in Nonprofessional Antigen-Presenting Cells with Absence of DM and Class II Colocalization

Kimberly A. Muczynski, Susan K. Anderson, and Donald Pious
J Immunol 1998 160: 3207-3216. [Abstract] [Full Text] [PDF]  

Maturation of Qa-1^b Class I Molecules Requires ß₂-Microglobulin But Is TAP Independent

Peter J. Robinson, Paul J. Travers, Arthur Stackpoole, Lorraine Flaherty, and Hakim Djaballah
J Immunol 1998 160: 3217-3224. [Abstract] [Full Text] [PDF]  

Kinetics of Multivalent Antigen DNP-BSA Binding to IgE-FcRI in Relationship to the Stimulated Tyrosine Phosphorylation of FcRI

Keli Xu, Byron Goldstein, David Holowka, and Barbara Baird
J Immunol 1998 160: 3225-3235. [Abstract] [Full Text] [PDF]  

CD8⁺ Memory T Cells (CD44^high, Ly-6C⁺) Are More Sensitive than Naive Cells (CD44^low, Ly-6C^-) to TCR/CD8 Signaling in Response to Antigen

Julie M. Curtsinger, Debra C. Lins, and Matthew F. Mescher
J Immunol 1998 160: 3236-3243. [Abstract] [Full Text] [PDF]  

Inhibition of an In Vitro CD4⁺ T Cell Alloresponse Using Altered Peptide Ligands

Claude Daniel, Arash Grakoui, and Paul M. Allen
J Immunol 1998 160: 3244-3250. [Abstract] [Full Text] [PDF]  

In Vivo ß-Adrenergic Stimulation Suppresses Natural Killer Activity and Compromises Resistance to Tumor Metastasis in Rats

Guy Shakhar and Shamgar Ben-Eliyahu
J Immunol 1998 160: 3251-3258. [Abstract] [Full Text] [PDF]  

Functional Consequences of Costimulation by ICAM-1 on IL-2 Gene Expression and T Cell Activation

Linda A. Zuckerman, Lara Pullen, and Jim Miller
J Immunol 1998 160: 3259-3268. [Abstract] [Full Text] [PDF]  

Differential Regulation of Translation and eIF4E Phosphorylation During Human Thymocyte Maturation

Laura Beretta, Nora G. Singer, Robert Hinderer, Anne-Claude Gingras, Bruce Richardson, Samir M. Hanash, and Nahum Sonenberg
J Immunol 1998 160: 3269-3273. [Abstract] [Full Text] [PDF]  

Ontogeny of the Heavy Chain Immunoglobulin Repertoire in Fetal Liver and Bone Marrow

Sylvie Delassus, Sylvie Darche, Philippe Kourilsky, and Ana Cumano
J Immunol 1998 160: 3274-3280. [Abstract] [Full Text] [PDF]  

Phenotype-Dependent Differences in Proteasome Subunit Composition and Cleavage Specificity in B Cell Lines

Teresa Frisan, Victor Levitsky, Axel Polack, and Maria G. Masucci
J Immunol 1998 160: 3281-3289. [Abstract] [Full Text] [PDF]  

CD34⁺CD38^-lin^- Cord Blood Cells Develop into Dendritic Cells in Human Thymic Stromal Monolayers and Thymic Nodules

G. Diego Miralles, Clayton A. Smith, Leona P. Whichard, Michael A. Morse, Barton F. Haynes, and Dhavalkumar D. Patel
J Immunol 1998 160: 3290-3298. [Abstract] [Full Text] [PDF]  

In Vivo IL-4 Responses to Anti-IgD Antibody Are MHC Class II Dependent and ß₂-Microglobulin Independent and Develop Normally in the Absence of IL-4 Priming of T Cells

Suzanne C. Morris, Robert L. Coffman, and Fred D. Finkelman
J Immunol 1998 160: 3299-3304. [Abstract] [Full Text] [PDF]  

Asymmetrical Phosphorylation and Function of Immunoreceptor Tyrosine-Based Activation Motif Tyrosines in B Cell Antigen Receptor Signal Transduction

Lily I. Pao, Sara J. Famiglietti, and John C. Cambier
J Immunol 1998 160: 3305-3314. [Abstract] [Full Text] [PDF]  

Epitope-Specific Antibody Response to IgE by Mimotope Immunization

Michael P. Rudolf, Monique Vogel, Franz Kricek, Christine Ruf, Adrian W. Zürcher, Roland Reuschel, Manfred Auer, Sylvia Miescher, and Beda M. Stadler
J Immunol 1998 160: 3315-3321. [Abstract] [Full Text] [PDF]  

Activation of Lyn, Blk, and Btk But Not Syk in CD72-Stimulated B Lymphocytes

Chandrasekar Venkataraman, Natarajan Muthusamy, Subramanian Muthukkumar, and Subbarao Bondada
J Immunol 1998 160: 3322-3329. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Involvement of C-Abl Tyrosine Kinase in Lipopolysaccharide- Induced Macrophage Activation

Quan Le, Rene Daniel, Siu-Wah Chung, Anthony D. Kang, Toby K. Eisenstein, Barnet M. Sultzer, Henry Simpkins, and Peter M. C. Wong
J Immunol 1998 160: 3330-3336. [Abstract] [Full Text] [PDF]  

Stimulation of Murine B Lymphocytes Induces a DNA Exonuclease Whose Activity on Switch-µ DNA Is Specifically Inhibited by Other Germ-Line Switch Region RNAs

Jürgen R. Müller and Kenneth B. Marcu
J Immunol 1998 160: 3337-3341. [Abstract] [Full Text] [PDF]  

Identification of the Second Heparin-Binding Domain in Human Complement Factor H

Timothy K. Blackmore, Jens Hellwage, Tania A. Sadlon, Naomi Higgs, Peter F. Zipfel, Helena M. Ward, and David L. Gordon
J Immunol 1998 160: 3342-3348. [Abstract] [Full Text] [PDF]  

Identification of a Domain in Human Factor H and Factor H-Like Protein-1 Required for the Interaction with Streptococcal M Proteins

Heike Kotarsky, Jens Hellwage, Eskil Johnsson, Christine Skerka, Henrik G. Svensson, Gunnar Lindahl, Ulf Sjöbring, and Peter F. Zipfel
J Immunol 1998 160: 3349-3354. [Abstract] [Full Text] [PDF]  

Identification of a Sequence That Mediates Promiscuous Binding of Invariant Chain to MHC Class II Allotypes

Ina M. Siebenkotten, Cornelia Carstens, and Norbert Koch
J Immunol 1998 160: 3355-3362. [Abstract] [Full Text] [PDF]  

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

Scott Southwood, John Sidney, Akihiro Kondo, Marie-France del Guercio, Ettore Appella, Stephen Hoffman, Ralph T. Kubo, Robert W. Chesnut, Howard M. Grey, and Alessandro Sette
J Immunol 1998 160: 3363-3373. [Abstract] [Full Text] [PDF]  

Spectratyping of TCR Expressed by CTL-Infiltrating Male Antigen (HY)-Disparate Allografts

Sean L. Johnston and Peter J. Wettstein
J Immunol 1998 160: 3374-3384. [Abstract] [Full Text] [PDF]  

Activation of STAT Proteins and Cytokine Genes in Human Th1 and Th2 Cells Generated in the Absence of IL-12 and IL-4

Richard Moriggl, Colette Kristofic, Bernd Kinzel, Sinisa Volarevic, Bernd Groner, and Volker Brinkmann1
J Immunol 1998 160: 3385-3392. [Abstract] [Full Text] [PDF]  

Effect of C2-Associated Carbohydrate Structure on Ig Effector Function: Studies with Chimeric Mouse-Human IgG1 Antibodies in Glycosylation Mutants of Chinese Hamster Ovary Cells

Ann Wright and Sherie L. Morrison
J Immunol 1998 160: 3393-3402. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

ß T Cell Response to Toxoplasma gondii in Previously Unexposed Individuals

Carlos S. Subauste, Franklin Fuh, Rene de Waal Malefyt, and Jack S. Remington
J Immunol 1998 160: 3403-3411. [Abstract] [Full Text] [PDF]  

Stimulation of Human T Lymphocytes by LPS Is MHC Unrestricted, But Strongly Dependent on B7 Interactions

Taila Mattern, Hans-Dieter Flad, Lore Brade, Ernst T. Rietschel, and Artur J. Ulmer
J Immunol 1998 160: 3412-3418. [Abstract] [Full Text] [PDF]  

A B7.1-Antibody Fusion Protein Retains Antibody Specificity and Ability to Activate Via the T Cell Costimulatory Pathway

Pia M. Challita-Eid, Manuel L. Penichet, Seung-Uon Shin, Tina Poles, Nima Mosammaparast, Kutubuddin Mahmood, Dennis J. Slamon, Sherie L. Morrison, and Joseph D. Rosenblatt
J Immunol 1998 160: 3419-3426. [Abstract] [Full Text] [PDF]  

Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis

Martina Deckert-Schlüter, Horst Bluethmann, Andrea Rang, Herbert Hof, and Dirk Schlüter
J Immunol 1998 160: 3427-3436. [Abstract] [Full Text] [PDF]  

A Bispecific Monoclonal Antibody Directed Against Both the Membrane-Bound Complement Regulator CD55 and the Renal Tumor-Associated Antigen G250 Enhances C3 Deposition and Tumor Cell Lysis by Complement

Vanessa T. Blok, Mohamed R. Daha, Odette Tijsma, Claire L. Harris, B. Paul Morgan, Gert Jan Fleuren, and Arko Gorter
J Immunol 1998 160: 3437-3443. [Abstract] [Full Text] [PDF]  

Purification of L-Selectin^low Cells Promotes the Generation of Highly Potent CD4 Antitumor Effector T Lymphocytes

Hiroshi Kagamu and Suyu Shu
J Immunol 1998 160: 3444-3452. [Abstract] [Full Text] [PDF]  

A Critical Role for IL-13 in Resistance to Intestinal Nematode Infection

Allison J. Bancroft, Andrew N. J. McKenzie, and Richard K. Grencis
J Immunol 1998 160: 3453-3461. [Abstract] [Full Text] [PDF]  

Revealing the In Vivo Behavior of CD4⁺ T Cells Specific for an Antigen Expressed in Escherichia coli

Zong-ming Chen and Marc K. Jenkins
J Immunol 1998 160: 3462-3470. [Abstract] [Full Text] [PDF]  

Trypanosoma cruzi: Tc52 Released Protein-Induced Increased Expression of Nitric Oxide Synthase and Nitric Oxide Production by Macrophages

Rodolfo Fernandez-Gomez, Serra Esteban, Rosalia Gomez-Corvera, Kherrouche Zoulika, and Ali Ouaissi
J Immunol 1998 160: 3471-3479. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Activation of Caspase 3 (CPP32)-Like Proteases Is Essential for TNF--Induced Hepatic Parenchymal Cell Apoptosis and Neutrophil-Mediated Necrosis in a Murine Endotoxin Shock Model

Hartmut Jaeschke, Michael A. Fisher, Judy A. Lawson, Carol A. Simmons, Anwar Farhood, and David A. Jones
J Immunol 1998 160: 3480-3486. [Abstract] [Full Text] [PDF]  

Ribavirin Inhibits Viral-Induced Macrophage Production of TNF, IL-1, the Procoagulant fgl2 Prothrombinase and Preserves Th1 Cytokine Production But Inhibits Th2 Cytokine Response

Qin Ning, Deron Brown, Jean Parodo, Mark Cattral, Reginald Gorczynski, Edward Cole, Laisum Fung, Jin Wen Ding, Ming Feng Liu, Ori Rotstein, M. James Phillips, and Gary Levy
J Immunol 1998 160: 3487-3493. [Abstract] [Full Text] [PDF]  

Dominant-Negative Effect of the Lymphocyte Function-Associated Antigen-1 ß (CD18) Cytoplasmic Domain on Leukocyte Adhesion to ICAM-1 and Fibronectin

Jose A. Rey-Ladino, Andrew M. Pyszniak, and Fumio Takei
J Immunol 1998 160: 3494-3501. [Abstract] [Full Text] [PDF]  

Regulation of Cell Growth by IL-2: Role of STAT5 in Protection from Apoptosis But Not in Cell Cycle Progression

José Zamorano, Helen Y. Wang, Rouxiang Wang, Yufang Shi, Gregory D. Longmore, and Achsah D. Keegan
J Immunol 1998 160: 3502-3512. [Abstract] [Full Text] [PDF]  

IL-17 Stimulates the Production and Expression of Proinflammatory Cytokines, IL-ß and TNF-, by Human Macrophages

Dragan V. Jovanovic, John A. Di Battista, Johanne Martel-Pelletier, François C. Jolicoeur, Yulan He, Mengkun Zhang, François Mineau, and Jean-Pierre Pelletier
J Immunol 1998 160: 3513-3521. [Abstract] [Full Text] [PDF]  

Involvement of NK1⁺ T Cells and Their IFN- Production in the Generalized Shwartzman Reaction

Kouetsu Ogasawara, Kazuyoshi Takeda, Wataru Hashimoto, Masayuki Satoh, Ryuhei Okuyama, Nobuaki Yanai, Masuo Obinata, Katsuo Kumagai, Haruhiko Takada, Hoshio Hiraide, and Shuhji Seki
J Immunol 1998 160: 3522-3527. [Abstract] [Full Text] [PDF]  

Dual Role of Ceramide in the Control of Apoptosis Following IL-2 Withdrawal

Ignacio Flores, Carlos Martinez-A, Yusuf A. Hannun, and Isabel Mérida
J Immunol 1998 160: 3528-3533. [Abstract] [Full Text] [PDF]  

The Multiligand-Binding Protein gC1qR, Putative C1q Receptor, Is a Mitochondrial Protein

Jürgen Dedio, Willi Jahnen-Dechent, Michael Bachmann, and Werner Müller-Esterl
J Immunol 1998 160: 3534-3542. [Abstract] [Full Text] [PDF]  

The Receptor for Complement Anaphylatoxin C3a Is Expressed by Myeloid Cells and Nonmyeloid Cells in Inflamed Human Central Nervous System: Analysis in Multiple Sclerosis and Bacterial Meningitis

Philippe Gasque, Sim K. Singhrao, Jim W. Neal, Piao Wang, Sakina Sayah, Marc Fontaine, and B. Paul Morgan
J Immunol 1998 160: 3543-3554. [Abstract] [Full Text] [PDF]  

IgE Versus IgG4 Production Can Be Differentially Regulated by IL-10

Pascale Jeannin, Sybille Lecoanet, Yves Delneste, Jean-François Gauchat, and Jean-Yves Bonnefoy
J Immunol 1998 160: 3555-3561. [Abstract] [Full Text] [PDF]  

Regulation of Macrophage Phagocytosis of Apoptotic Cells by cAMP

Adriano G. Rossi, Judith C. McCutcheon, Noémi Roy, Edwin R. Chilvers, Christopher Haslett, and Ian Dransfield
J Immunol 1998 160: 3562-3568. [Abstract] [Full Text] [PDF]  

Human Eotaxin Induces ₄ and ß₂ Integrin-Dependent Eosinophil Accumulation in Rat Skin In Vivo: Delayed Generation of Eotaxin in Response to IL-4

Maria-Jesus Sanz, Paul D. Ponath, Charles R. Mackay, Walter Newman, Masayuki Miyasaka, Tayuka Tamatani, Brian F. Flanagan, Roy R. Lobb, Timothy J. Williams, Sussan Nourshargh, and Peter J. Jose
J Immunol 1998 160: 3569-3576. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

B Cell Sensitization to Helminthic Infection Develops In Utero in Humans

Christopher L. King, Indu Malhotra, Peter Mungai, Alex Wamachi, John Kioko, John H. Ouma, and James W. Kazura
J Immunol 1998 160: 3578-3584. [Abstract] [Full Text] [PDF]  

Dendritic Cells and Macrophages Are the First and Major Producers of TNF- in Pancreatic Islets in the Nonobese Diabetic Mouse

Eva Dahlén, Kim Dawe, Lennart Ohlsson, and Gunnar Hedlund
J Immunol 1998 160: 3585-3593. [Abstract] [Full Text] [PDF]  

Clonal Analysis of Intrahepatic B Cells from HCV-Infected Patients With and Without Mixed Cryoglobulinemia

Domenico Sansonno, Salvatore De Vita, Anna Rina Iacobelli, Vito Cornacchiulo, Mauro Boiocchi, and Franco Dammacco
J Immunol 1998 160: 3594-3601. [Abstract] [Full Text] [PDF]  

Active Wegener’s Granulomatosis Is Associated with HLA-DR⁺ CD4⁺ T Cells Exhibiting an Unbalanced Th1-Type T Cell Cytokine Pattern: Reversal with IL-10

Björn R. Lúdvíksson, Michael C. Sneller, Kevin S. Chua, Cheryl Talar-Williams, Carol A. Langford, Rolf O. Ehrhardt, Anthony S. Fauci, and Warren Strober
J Immunol 1998 160: 3602-3609. [Abstract] [Full Text] [PDF]  

Extracellular Granzymes A and B in Humans: Detection of Native Species During CTL Responses In Vitro and In Vivo

Elisabeth H. A. Spaeny-Dekking, William L. Hanna, Angela M. Wolbink, Peter C. Wever, Alain J. Kummer, Anton J. G. Swaak, Jaap M. Middeldorp, Han G. Huisman, Christopher J. Froelich, and C. Erik Hack
J Immunol 1998 160: 3610-3616. [Abstract] [Full Text] [PDF]  

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