CUTTING EDGE:

Cutting Edge: CD40 Engagement Up-Regulates Cyclooxygenase-2 Expression and Prostaglandin E₂ Production in Human Lung Fibroblasts

Ying Zhang, H. James Cao, Beth Graf, Heather Meekins, Terry J. Smith, and Richard P. Phipps
J Immunol 1998 160: 1053-1057. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

The Amino-Terminal Src Homology 2 Domain of Phospholipase C1 Is Essential for TCR-Induced Tyrosine Phosphorylation of Phospholipase C1

Bogdan Stoica, Karen E. DeBell, Laurie Graham, Barbara L. Rellahan, Maria A. Alava, Jorge Laborda, and Ezio Bonvini
J Immunol 1998 160: 1059-1066. [Abstract] [Full Text] [PDF]  

Differential Effect of Anti-B7-1 and Anti-M150 Antibodies in Restricting the Delivery of Costimulatory Signals from B Cells and Macrophages

Javed N. Agrewala, Susmit Suvas, Rakesh K. Verma, and Gyan C. Mishra
J Immunol 1998 160: 1067-1077. [Abstract] [Full Text] [PDF]  

Follicular Dendritic Cell (FDC) Precursors in Primary Lymphoid Tissues

Zoher F. Kapasi, Dahui Qin, William G. Kerr, Marie H. Kosco-Vilbois, Leonard D. Shultz, John G. Tew, and Andras K. Szakal
J Immunol 1998 160: 1078-1084. [Abstract] [Full Text] [PDF]  

Avoidance of Self-Reactivity Results in Skewed CTL Responses to Rare Components of Synthetic Immunogens

Anthony W. Purcell, Weisan Chen, Nicholas J. Ede, Jeffrey J. Gorman, John V. Fecondo, David C. Jackson, Yuming Zhao, and James McCluskey
J Immunol 1998 160: 1085-1090. [Abstract] [Full Text] [PDF]  

Class I-Restricted Alloreactive Cytotoxic T Lymphocytes Recognize a Complex Array of Specific MHC-Associated Peptides

Wei Wang, Stephen Man, Pamela H. Gulden, Donald F. Hunt, and Victor H. Engelhard
J Immunol 1998 160: 1091-1097. [Abstract] [Full Text] [PDF]  

Natural Killer Cell Depletion Fails to Influence Initial CD4 T Cell Commitment In Vivo in Exogenous Antigen-Stimulated Cytokine and Antibody Responses

MingDong Wang, Cynthia A. Ellison, John G. Gartner, and Kent T. HayGlass
J Immunol 1998 160: 1098-1105. [Abstract] [Full Text] [PDF]  

Role of CD38 and Its Ligand in the Regulation of MHC-Nonrestricted Cytotoxic T Cells

Alessandra Cesano, Sophie Visonneau, Silvia Deaglio, Fabio Malavasi, and Daniela Santoli
J Immunol 1998 160: 1106-1115. [Abstract] [Full Text] [PDF]  

A Fusion of the EBV Latent Membrane Protein-1 (LMP1) Transmembrane Domains to the CD40 Cytoplasmic Domain Is Similar to LMP1 in Constitutive Activation of Epidermal Growth Factor Receptor Expression, Nuclear Factor-B, and Stress-Activated Protein Kinase

Eudoxia Hatzivassiliou, William E. Miller, Nancy Raab-Traub, Elliott Kieff, and George Mosialos
J Immunol 1998 160: 1116-1121. [Abstract] [Full Text] [PDF]  

Antagonism of Immunostimulatory CpG-Oligodeoxynucleotides by Quinacrine, Chloroquine, and Structurally Related Compounds

Donald E. Macfarlane and Lori Manzel
J Immunol 1998 160: 1122-1131. [Abstract] [Full Text] [PDF]  

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

Joseph R. Piccotti, Kewang Li, Sherri Y. Chan, Jessica Ferrante, Jeanne Magram, Ernst J. Eichwald, and D. Keith Bishop
J Immunol 1998 160: 1132-1138. [Abstract] [Full Text] [PDF]  

Autologous Human Monocyte-Derived Dendritic Cells Genetically Modified to Express Melanoma Antigens Elicit Primary Cytotoxic T Cell Responses In Vitro: Enhancement by Cotransfection of Genes Encoding the Th1-Biasing Cytokines IL-12 and IFN-

Thomas Tüting, Cara C. Wilson, Dina M. Martin, Yvette L. Kasamon, Jennifer Rowles, Debora I. Ma, Craig L. Slingluff, Jr., Stephan N. Wagner, Pierre van der Bruggen, Joseph Baar, Michael T. Lotze, and Walter J. Storkus
J Immunol 1998 160: 1139-1147. [Abstract] [Full Text] [PDF]  

Sequestration of CD4-Associated Lck from the TCR Complex May Elicit T Cell Hyporesponsiveness in Nonobese Diabetic Mice

Jian Zhang, Konstantin Salojin, and Terry L. Delovitch
J Immunol 1998 160: 1148-1157. [Abstract] [Full Text] [PDF]  

The Ly-49 Family: Regulation of Cytotoxicity and Cytokine Production in Murine CD3⁺ Cells

John R. Ortaldo, Robin Winkler-Pickett, Anna T. Mason, and Llewellyn H. Mason
J Immunol 1998 160: 1158-1165. [Abstract] [Full Text] [PDF]  

IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells

Xiaohui Peng, Jacques E. Remacle, Ahmad Kasran, Danny Huylebroeck, and Jan L. Ceuppens
J Immunol 1998 160: 1166-1172. [Abstract] [Full Text] [PDF]  

Migration of Lymphoid Cells from Vaginal Epithelium to Iliac Lymph Nodes in Relation to Vaginal Infection by Herpes Simplex Virus Type 2

Nicholas J. C. King, Earl L. Parr, and Margaret B. Parr
J Immunol 1998 160: 1173-1180. [Abstract] [Full Text] [PDF]  

Dual Role of Dendritic Cells in the Induction and Down-Regulation of Antigen-Specific Cutaneous Inflammation

Maya Krasteva, Jeanne Kehren, Françoise Horand, Hitoshi Akiba, Geneviève Choquet, Marie-Thérèse Ducluzeau, Rosine Tédone, Jean-Luc Garrigue, Dominique Kaiserlian, and Jean-François Nicolas
J Immunol 1998 160: 1181-1190. [Abstract] [Full Text] [PDF]  

Differential Expression of the Melatonin Receptor in Human Monocytes

Marc J. Barjavel, Zahra Mamdouh, Nadjibe Raghbate, and Ouahid Bakouche
J Immunol 1998 160: 1191-1197. [Abstract] [Full Text] [PDF]  

Cholera Toxin and Cholera Toxin B Subunit Induce IgA Switching Through the Action of TGF-ß1

Pyeung-Hyeun Kim, Lars Eckmann, Wha Jung Lee, Wonkyo Han, and Martin F. Kagnoff
J Immunol 1998 160: 1198-1203. [Abstract] [Full Text] [PDF]  

Polymorphism Within a TCRAV Family Influences the Repertoire Through Class I/II Restriction

Bee-Cheng Sim, Jay L. Wung, and Nicholas R. J. Gascoigne
J Immunol 1998 160: 1204-1211. [Abstract] [Full Text] [PDF]  

CD4⁺CD25⁺ T Cells Inhibit Both the Induction and Effector Function of Autoreactive T Cells and Represent a Unique Lineage of Immunoregulatory Cells

Elisabeth Suri-Payer, Anna Z. Amar, Angela M. Thornton, and Ethan M. Shevach
J Immunol 1998 160: 1212-1218. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

In Vitro Comparison of the Biologic Activities of Monoclonal Monomeric IgA, Polymeric IgA, and Secretory IgA

Kathryn B. Renegar, Graham D. F. Jackson, and Jiri Mestecky
J Immunol 1998 160: 1219-1223. [Abstract] [Full Text] [PDF]  

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-B Activation in Hemopoietic Progenitor Cells

Tsunehiro Oyama, Sophia Ran, Tadao Ishida, Sorena Nadaf, Lawrence Kerr, David P. Carbone, and Dmitry I. Gabrilovich
J Immunol 1998 160: 1224-1232. [Abstract] [Full Text] [PDF]  

Structure, Diversity, and Repertoire of V_H Families in the Mexican Axolotl

Rachel Golub and Jacques Charlemagne
J Immunol 1998 160: 1233-1239. [Abstract] [Full Text] [PDF]  

CpG DNA Rescue from Anti-IgM-Induced WEHI-231 B Lymphoma Apoptosis via Modulation of IB and IBß and Sustained Activation of Nuclear Factor-B/c-Rel

Ae-Kyung Yi and Arthur M. Krieg
J Immunol 1998 160: 1240-1245. [Abstract] [Full Text] [PDF]  

V_H Mutant Rabbits Lacking the V_H1a2 Gene Develop a2⁺ B Cells in the Appendix by Gene Conversion-Like Alteration of a Rearranged V_H4 Gene

Devinder Sehgal, Rose G. Mage, and Enrico Schiaffella
J Immunol 1998 160: 1246-1255. [Abstract] [Full Text] [PDF]  

Biochemical and Functional Analyses of Chromatin Changes at the TCR-ß Gene Locus During CD4^-CD8^- to CD4⁺CD8⁺ Thymocyte Differentiation

Samit Chattopadhyay, Charles E. Whitehurst, Frieder Schwenk, and Jianzhu Chen
J Immunol 1998 160: 1256-1267. [Abstract] [Full Text] [PDF]  

An Intronic Silencer Regulates B Lymphocyte Cell- and Stage-Specific Expression of the Human Complement Receptor Type 2 (CR2, CD21) Gene

Karen W. Makar, Christine T. N. Pham, Marlin H. Dehoff, Siobhan M. O’Connor, Susan M. Jacobi, and V. Michael Holers
J Immunol 1998 160: 1268-1278. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Eosinophils Bind Rhinovirus and Activate Virus-Specific T Cells

Zeev T. Handzel, William W. Busse, Julie B. Sedgwick, Rose Vrtis, Wai Ming Lee, E. A. B. Kelly, and James E. Gern
J Immunol 1998 160: 1279-1284. [Abstract] [Full Text] [PDF]  

Protective Effect on Leishmania major Infection of Migration Inhibitory Factor, TNF-, and IFN- Administered Orally via Attenuated Salmonella typhimurium

Damo Xu, Stephen J. McSorley, Lawrence Tetley, Stephen Chatfield, Gordon Dougan, W. Ling Chan, Abhay Satoskar, John R. David, and Foo Y. Liew
J Immunol 1998 160: 1285-1289. [Abstract] [Full Text] [PDF]  

Cytokine Activation Leads to Acidification and Increases Maturation of Mycobacterium avium-Containing Phagosomes in Murine Macrophages

Ulrich E. Schaible, Sheila Sturgill-Koszycki, Paul H. Schlesinger, and David G. Russell
J Immunol 1998 160: 1290-1296. [Abstract] [Full Text] [PDF]  

Internalization of Chlamydia by Dendritic Cells and Stimulation of Chlamydia-Specific T Cells

David M. Ojcius, Yolanda Bravo de Alba, Jean M. Kanellopoulos, Ray A. Hawkins, Kathy A. Kelly, Roger G. Rank, and Alice Dautry-Varsat
J Immunol 1998 160: 1297-1303. [Abstract] [Full Text] [PDF]  

Requirement for In Vivo Production of IL-4, But Not IL-10, in the Induction of Proliferative Suppression by Filarial Parasites

Andrew S. MacDonald, Rick M. Maizels, Rachel A. Lawrence, Ian Dransfield, and Judith E. Allen
J Immunol 1998 160: 1304-1312. [Abstract] [Full Text] [PDF]  

Activation-Induced T Cell Death Exacerbates Trypanosoma cruzi Replication in Macrophages Cocultured with CD4⁺ T Lymphocytes from Infected Hosts

Marise P. Nunes, Regis M. Andrade, Marcela F. Lopes, and George A. DosReis
J Immunol 1998 160: 1313-1319. [Abstract] [Full Text] [PDF]  

Development of Th1 and Th2 Populations and the Nature of Immune Responses to Hepatitis B Virus DNA Vaccines Can Be Modulated by Codelivery of Various Cytokine Genes

Yen-Hung Chow, Bor-Luen Chiang, Yueh-Lun Lee, Wei-Kuang Chi, Wen-Chang Lin, Yen-Teen Chen, and Mi-Hua Tao
J Immunol 1998 160: 1320-1329. [Abstract] [Full Text] [PDF]  

Activation of Mitogen-Activated Protein Kinase Pathways by Mycoplasma fermentans Membrane Lipoproteins in Murine Macrophages: Involvement in Cytokine Synthesis

Georges Rawadi, Valerie Ramez, Brigitte Lemercier, and Sergio Roman-Roman
J Immunol 1998 160: 1330-1339. [Abstract] [Full Text] [PDF]  

Decreased Resistance of TNF Receptor p55- and p75-Deficient Mice to Chronic Toxoplasmosis Despite Normal Activation of Inducible Nitric Oxide Synthase In Vivo

George S. Yap, Tanya Scharton-Kersten, Hugues Charest, and Alan Sher
J Immunol 1998 160: 1340-1345. [Abstract] [Full Text] [PDF]  

Activation of Complement by Mannose-Binding Lectin on Isogenic Mutants of Neisseria meningitidis Serogroup B

Dominic L. Jack, Alister W. Dodds, Natasha Anwar, Catherine A. Ison, Alex Law, Matthias Frosch, Malcolm W. Turner, and Nigel J. Klein
J Immunol 1998 160: 1346-1353. [Abstract] [Full Text] [PDF]  

Pre-Exposure to Oxidative Stress Decreases the Nuclear Factor-B-Dependent Transcription in T Lymphocytes

Nina Lahdenpohja, Kimmo Savinainen, and Mikko Hurme
J Immunol 1998 160: 1354-1358. [Abstract] [Full Text] [PDF]  

Factors Involved in Regulating Primary and Secondary Immunity to Infection with Histoplasma capsulatum: TNF- Plays a Critical Role in Maintaining Secondary Immunity in the Absence of IFN-

Ping Zhou, Giorgina Miller, and Robert A. Seder
J Immunol 1998 160: 1359-1368. [Abstract] [Full Text] [PDF]  

Immune Response Against Large Tumors Eradicated by Treatment with Cyclophosphamide and IL-12

Kangla Tsung, Jennifer B. Meko, Ying L. Tsung, Gary R. Peplinski, and Jeffrey A. Norton
J Immunol 1998 160: 1369-1377. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Induction of Pulmonary Allergic Responses by Antigen-Specific Th2 Cells

Xiu-Min Li, Brian H. Schofield, Qian-Fei Wang, Kawn-Hyoung Kim, and Shau-Ku Huang
J Immunol 1998 160: 1378-1384. [Abstract] [Full Text] [PDF]  

CC Chemokine Receptors 1 and 3 Are Differentially Regulated by IL-5 During Maturation of Eosinophilic HL-60 Cells

H. Lee Tiffany, Ghalib Alkhatib, Christophe Combadiere, Edward A. Berger, and Philip M. Murphy
J Immunol 1998 160: 1385-1392. [Abstract] [Full Text] [PDF]  

Activation of Protein Kinase C- and Phosphatidylinositol 3'-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I

Qiang Liu, Wei Ning, Robert Dantzer, Gregory G. Freund, and Keith W. Kelley
J Immunol 1998 160: 1393-1401. [Abstract] [Full Text] [PDF]  

Inflammatory Agonists Induce Cyclooxygenase Type 2 Expression by Human Neutrophils

Christopher G. Maloney, William A. Kutchera, Kurt H. Albertine, Thomas M. McIntyre, Stephen M. Prescott, and Guy A. Zimmerman
J Immunol 1998 160: 1402-1410. [Abstract] [Full Text] [PDF]  

Alternative Macrophage Activation-Associated CC-Chemokine-1, a Novel Structural Homologue of Macrophage Inflammatory Protein-1 with a Th2-Associated Expression Pattern

Vitam Kodelja, Carola Müller, Oliver Politz, Nahid Hakij, Constantin E. Orfanos, and Sergij Goerdt
J Immunol 1998 160: 1411-1418. [Abstract] [Full Text] [PDF]  

Role of the Mitogen-Activated Protein Kinases in the Expression of the Kinin B₁ Receptors Induced by Tissue Injury

Jean-François Larrivée, Dimcho R. Bachvarov, François Houle, Jacques Landry, Jacques Huot, and François Marceau
J Immunol 1998 160: 1419-1426. [Abstract] [Full Text] [PDF]  

The Human S100 Protein MRP-14 Is a Novel Activator of the ß₂ Integrin Mac-1 on Neutrophils

Rebecca A. Newton and Nancy Hogg
J Immunol 1998 160: 1427-1435. [Abstract] [Full Text] [PDF]  

Angiotensin II Generation at the Cell Surface of Activated Neutrophils: Novel Cathepsin G-Mediated Catalytic Activity That Is Resistant to Inhibition

Caroline A. Owen and Edward J. Campbell
J Immunol 1998 160: 1436-1443. [Abstract] [Full Text] [PDF]  

Differences in Nitric Oxide Production by Superficial and Deep Human Articular Chondrocytes: Implications for Proteoglycan Turnover in Inflammatory Joint Diseases

H. J. Häuselmann, M. Stefanovic-Racic, B. A. Michel, and C. H. Evans
J Immunol 1998 160: 1444-1448. [Abstract] [Full Text] [PDF]  

Cytokine Induction of MIP-1 and MIP-1ß in Human Fetal Microglia

Carrie M. McManus, Celia F. Brosnan, and Joan W. Berman
J Immunol 1998 160: 1449-1455. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Genetic Immunization Against the Human Thyrotropin Receptor Causes Thyroiditis and Allows Production of Monoclonal Antibodies Recognizing the Native Receptor

S. Costagliola, P. Rodien, M.-C. Many, M. Ludgate, and G. Vassart
J Immunol 1998 160: 1458-1465. [Abstract] [Full Text] [PDF]  

Streptococcal Cell Wall-Induced Arthritis: Requirements for IL-4, IL-10, IFN-, and Monocyte Chemoattractant Protein-1

Ralph C. Schimmer, Denis J. Schrier, Craig M. Flory, Keith D. Laemont, David Tung, Alan L. Metz, Hans P. Friedl, Mary Carol Conroy, Jeffrey S. Warren, Beatrice Beck, and Peter A. Ward
J Immunol 1998 160: 1466-1471. [Abstract] [Full Text] [PDF]  

Subcongenic Analysis of the Idd13 Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for ß₂-Microglobulin

David V. Serreze, Margot Bridgett, Harold D. Chapman, Emmie Chen, Scott D. Richard, and Edward H. Leiter
J Immunol 1998 160: 1472-1478. [Abstract] [Full Text] [PDF]  

Liver-Derived CTL in Hepatitis C Virus Infection: Breadth and Specificity of Responses in a Cohort of Persons with Chronic Infection

David K. H. Wong, Darryll D. Dudley, Nezam H. Afdhal, Jules Dienstag, Charles M. Rice, Liping Wang, Michael Houghton, Bruce D. Walker, and Margaret J. Koziel
J Immunol 1998 160: 1479-1488. [Abstract] [Full Text] [PDF]  

Cells Transfected with a Non-Neutralizing Antibody Gene Are Resistant to HIV Infection: Targeting the Endoplasmic Reticulum and Trans-Golgi Network

Paul Zhou, Simoy Goldstein, Krishnakumar Devadas, Deepanker Tewari, and Abner Louis Notkins
J Immunol 1998 160: 1489-1496. [Abstract] [Full Text] [PDF]  

Novel Immunoregulatory B Cell Pathways Revealed by lpr-+ Mixed Chimeras

Eric S. Sobel, Vellalore N. Kakkanaiah, Joel Schiffenbauer, Elizabeth A. Reap, Philip L. Cohen, and Robert A. Eisenberg
J Immunol 1998 160: 1497-1503. [Abstract] [Full Text] [PDF]  

Mechanisms of Acquired Thymic Tolerance In Vivo: Intrathymic Injection of Antigen Induces Apoptosis of Thymocytes and Peripheral T Cell Anergy

Wanjun Chen, Mohamed H. Sayegh, and Samia J. Khoury
J Immunol 1998 160: 1504-1508. [Abstract] [Full Text] [PDF]  

A Non-Sense Mutation at Arg⁹⁵ Is Predominant in Complement 9 Deficiency in Japanese

Takahiko Horiuchi, Hiroaki Nishizaka, Takeshi Kojima, Takuya Sawabe, Yoshiyuki Niho, Peter M. Schneider, Shoichi Inaba, Kouko Sakai, Kenshi Hayashi, Chinami Hashimura, and Yasuo Fukumori
J Immunol 1998 160: 1509-1513. [Abstract] [Full Text] [PDF]  

Cytokine Production and Surface Marker Expression in Acute and Stable Multiple Sclerosis: Altered IL-12 Production and Augmented Signaling Lymphocytic Activation Molecule (SLAM)-Expressing Lymphocytes in Acute Multiple Sclerosis

Pasquale Ferrante, Maria Luisa Fusi, Marina Saresella, Domenico Caputo, Mara Biasin, Daria Trabattoni, Antonino Salvaggio, Enrico Clerici, Jan E. de Vries, Gregorio Aversa, Carlo L. Cazzullo, and Mario Clerici
J Immunol 1998 160: 1514-1521. [Abstract] [Full Text] [PDF]  

Intracellular and Surface Expression of the HIV-1 Coreceptor CXCR4/Fusin on Various Leukocyte Subsets: Rapid Internalization and Recycling Upon Activation

Reinhold Förster, Elisabeth Kremmer, Andreas Schubel, Dagmar Breitfeld, Andrea Kleinschmidt, Christoph Nerl, Günter Bernhardt, and Martin Lipp
J Immunol 1998 160: 1522-1531. [Abstract] [Full Text] [PDF]  

Expansion of Autoreactive T Cells in Multiple Sclerosis Is Independent of Exogenous B7 Costimulation

Christian Scholz, Kurt T. Patton, David E. Anderson, Gordon J. Freeman, and David A. Hafler
J Immunol 1998 160: 1532-1538. [Abstract] [Full Text] [PDF]  

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