CUTTING EDGE:

Cutting Edge: Signals from the B Lymphocyte Antigen Receptor Regulate MHC Class II Containing Late Endosomes

Karyn Siemasko, Bartholomew J. Eisfelder, Edward Williamson, Shara Kabak, and Marcus R. Clark
J Immunol 1998 160: 5203-5208. [Abstract] [Full Text] [PDF]  

Cutting Edge: Novel RNA Ligands Able to Bind CD4 Antigen and Inhibit CD4⁺ T Lymphocyte Function

Elmar Kraus, William James, and A. Neil Barclay
J Immunol 1998 160: 5209-5212. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Adenovirus-Mediated Transfer of Viral IL-10 Gene Inhibits Murine Collagen-Induced Arthritis

Florence Apparailly, Claudie Verwaerde, Chantal Jacquet, Claude Auriault, Jacques Sany, and Christian Jorgensen
J Immunol 1998 160: 5213-5220. [Abstract] [Full Text] [PDF]  

Early Preferential Stimulation of T Cells by TNF-

Michael Lahn, Harshan Kalataradi, Peter Mittelstadt, Elizabeth Pflum, Michaelann Vollmer, Carol Cady, Akiko Mukasa, Anthony T. Vella, David Ikle, Ronald Harbeck, Rebecca O’Brien, and Willi Born
J Immunol 1998 160: 5221-5230. [Abstract] [Full Text] [PDF]  

CD95 (Fas)-Based, Superantigen-Dependent, CD4⁺ T Cell-Mediated Down-Regulation of Human In Vitro Immunoglobulin Responses

William Stohl, Julie E. Elliott, David H. Lynch, and Peter A. Kiener
J Immunol 1998 160: 5231-5238. [Abstract] [Full Text] [PDF]  

Killer Cell Inhibitory Receptors for MHC Class I Molecules Regulate Lysis of Melanoma Cells Mediated by NK cells, T Cells, and Antigen-Specific CTL

Alexander B. H. Bakker, Joseph H. Phillips, Carl G. Figdor, and Lewis L. Lanier
J Immunol 1998 160: 5239-5245. [Abstract] [Full Text] [PDF]  

In Vivo Inflammatory Response to a Prototypic B Cell Superantigen: Elicitation of an Arthus Reaction by Staphylococcal Protein A

Lisa M. Kozlowski, Weiping Li, Michael Goldschmidt, and Arnold I. Levinson
J Immunol 1998 160: 5246-5252. [Abstract] [Full Text] [PDF]  

Two Types of Anti-TL (Thymus Leukemia) CTL Clones with Distinct Target Specificities: Differences in Cytotoxic Mechanisms and Accessory Molecule Requirements

Kunio Tsujimura, Toshitada Takahashi, Shigeru Iwase, Yasue Matsudaira, Yoko Kaneko, Hideo Yagita, and Yuichi Obata
J Immunol 1998 160: 5253-5261. [Abstract] [Full Text] [PDF]  

Generation of an MHC Class II-Restricted T Cell Epitope by Extracellular Processing of Hepatitis Antigen

Daniele Accapezzato, Roberto Nisini, Marino Paroli, Guglielmo Bruno, Ferruccio Bonino, Michael Houghton, and Vincenzo Barnaba
J Immunol 1998 160: 5262-5266. [Abstract] [Full Text] [PDF]  

Two T Cell Epitopes from the M5 Protein of Viable Streptococcus pyogenes Engage Different Pathways of Bacterial Antigen Processing in Mouse Macrophages

Alexei A. Delvig and John H. Robinson
J Immunol 1998 160: 5267-5272. [Abstract] [Full Text] [PDF]  

Expression of Complement Receptors 1 and 2 on Follicular Dendritic Cells Is Necessary for the Generation of a Strong Antigen-Specific IgG Response

Yifu Fang, Chenguang Xu, Yang-Xin Fu, V. Michael Holers, and Hector Molina
J Immunol 1998 160: 5273-5279. [Abstract] [Full Text] [PDF]  

Generation, Persistence, and Modulation of Th0 Effector Cells: Role of Autocrine IL-4 and IFN-

Kent T. Miner and Michael Croft
J Immunol 1998 160: 5280-5287. [Abstract] [Full Text] [PDF]  

Autocrine and Paracrine Apoptosis Are Mediated by Differential Regulation of Fas Ligand Activity in Two Distinct Jurkat T Cell Populations

Xiao Su, Jianhua Cheng, Weimin Liu, Changdan Liu, Zheng Wang, PingAr Yang, Tong Zhou, and John D. Mountz
J Immunol 1998 160: 5288-5293. [Abstract] [Full Text] [PDF]  

Testosterone and IL-6 Requirements for Human C-Reactive Protein Gene Expression in Transgenic Mice

Alexander J. Szalai, Frederik W. van Ginkel, Stacie A. Dalrymple, Richard Murray, Jerry R. McGhee, and John E. Volanakis
J Immunol 1998 160: 5294-5299. [Abstract] [Full Text] [PDF]  

Macrophages Induce Cellular Immunity by Activating Th1 Cell Responses and Suppressing Th2 Cell Responses

Marjory Desmedt, Pieter Rottiers, Hans Dooms, Walter Fiers, and Johan Grooten
J Immunol 1998 160: 5300-5308. [Abstract] [Full Text] [PDF]  

Perforin and IFN- Are Involved in the Antitumor Effects of Antibody-Targeted Superantigens

Alexander Rosendahl, Karin Kristensson, Johan Hansson, Kristian Riesbeck, Terje Kalland, and Mikael Dohlsten
J Immunol 1998 160: 5309-5313. [Abstract] [Full Text] [PDF]  

1,25-Dihydroxyvitamin D₃ Is a Positive Regulator for the Two Anti-Encephalitogenic Cytokines TGF-ß1 and IL-4

Margherita T. Cantorna, William D. Woodward, Colleen E. Hayes, and Hector F. DeLuca
J Immunol 1998 160: 5314-5319. [Abstract] [Full Text] [PDF]  

Central Nervous System Microglial Cell Activation and Proliferation Follows Direct Interaction with Tissue-Infiltrating T Cell Blasts

Jonathon D. Sedgwick, Andrew L. Ford, Eléna Foulcher, and Rhonda Airriess
J Immunol 1998 160: 5320-5330. [Abstract] [Full Text] [PDF]  

Topical FK506 Suppresses Cytokine and Costimulatory Molecule Expression in Epidermal and Local Draining Lymph Node Cells During Primary Skin Immune Responses

Bernhard Homey, Till Assmann, Hans-Werner Vohr, Peter Ulrich, Antti I. Lauerma, Thomas Ruzicka, Percy Lehmann, and Hans-Christian Schuppe
J Immunol 1998 160: 5331-5340. [Abstract] [Full Text] [PDF]  

Increased Threshold for TCR-Mediated Signaling Controls Self Reactivity of Intraepithelial Lymphocytes

Sarah R. Guehler, Rosalynde J. Finch, Jeffrey A. Bluestone, and Terrence A. Barrett
J Immunol 1998 160: 5341-5346. [Abstract] [Full Text] [PDF]  

Alternative Metabolic States in Murine Macrophages Reflected by the Nitric Oxide Synthase/Arginase Balance: Competitive Regulation by CD4⁺ T Cells Correlates with Th1/Th2 Phenotype

Markus Munder, Klaus Eichmann, and Manuel Modolell
J Immunol 1998 160: 5347-5354. [Abstract] [Full Text] [PDF]  

Rapamycin Inhibits the Generation of Graft-Versus-Host Disease- and Graft-Versus-Leukemia-Causing T Cells by Interfering with the Production of Th1 or Th1 Cytotoxic Cytokines

Bruce R. Blazar, Patricia A. Taylor, Angela Panoskaltsis-Mortari, and Daniel A. Vallera
J Immunol 1998 160: 5355-5365. [Abstract] [Full Text] [PDF]  

Regulation of Cell Morphology in B Lymphocytes by IL-4: Evidence for Induced Cytoskeletal Changes

Edward J. Davey, Johan Thyberg, Daniel H. Conrad, and Eva Severinson
J Immunol 1998 160: 5366-5373. [Abstract] [Full Text] [PDF]  

Overexpression of p65 and c-Jun Substitutes for B7-1 Costimulation by Targeting the CD28RE Within the IL-2 Promoter

Eduardo Parra, Kathleen McGuire, Gunnar Hedlund, and Mikael Dohlsten
J Immunol 1998 160: 5374-5381. [Abstract] [Full Text] [PDF]  

Alloreactive T Cells That Do Not Require TCR and CD8 Coengagement Are Present in Naive Mice and Contribute to Graft Rejection

Pamela A. Smith and Terry A. Potter
J Immunol 1998 160: 5382-5389. [Abstract] [Full Text] [PDF]  

Identification of a Dynamic Intracellular Reservoir of CD86 Protein in Peripheral Blood Monocytes That Is Not Associated with the Golgi Complex

Christine Smyth, Grant Logan, Ron P. Weinberger, Peter B. Rowe, Ian E. Alexander, and Jason A. Smythe
J Immunol 1998 160: 5390-5396. [Abstract] [Full Text] [PDF]  

Susceptibility and Resistance to Antigen-Induced Apoptosis in the Thymus of Transgenic Mice

Raquel Tarazona, Owen Williams, Demetrius Moskophidis, Lesley A. Smyth, Yujiro Tanaka, Marianna Murdjeva, Andreas Wack, Clio Mamalaki, and Dimitris Kioussis
J Immunol 1998 160: 5397-5403. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

Calreticulin and Calnexin Interact with Different Protein and Glycan Determinants During the Assembly of MHC Class I

Michael R. Harris, Yik Y. L. Yu, Cathy S. Kindle, Ted H. Hansen, and Joyce C. Solheim
J Immunol 1998 160: 5404-5409. [Abstract] [Full Text] [PDF]  

T Cells Expressing Receptors of Different Affinity for Antigen Ligands Reveal a Unique Role for p59^fyn in T Cell Development and Optimal Stimulation of T Cells by Antigen

Oliver Utting, Soo-Jeet Teh, and Hung-Sia Teh
J Immunol 1998 160: 5410-5419. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Identification of the Immunodominant T Cell Epitope of p38, a Major Egg Antigen, and Characterization of the Epitope-Specific Th Responsiveness During Murine Schistosomiasis Mansoni

Yiguang Chen and Dov L. Boros
J Immunol 1998 160: 5420-5427. [Abstract] [Full Text] [PDF]  

IL-12 Promotes Drug-Induced Clearance of Mycobacterium avium Infection in Mice

T. Mark Doherty and Alan Sher
J Immunol 1998 160: 5428-5435. [Abstract] [Full Text] [PDF]  

IL-5-Dependent Immunity to Microfilariae Is Independent of IL-4 in a Mouse Model of Onchocerciasis

Philip J. Hogarth, Mark J. Taylor, and Albert E. Bianco
J Immunol 1998 160: 5436-5440. [Abstract] [Full Text] [PDF]  

Role of the Hypothalamic Pituitary Adrenal Axis and IL-6 in Stress-Induced Reactivation of Latent Herpes Simplex Virus Type 1

Sansanee Noisakran, William P. Halford, Livia Veress, and Daniel J. J. Carr
J Immunol 1998 160: 5441-5447. [Abstract] [Full Text] [PDF]  

Fas Ligand-Induced Apoptosis of Infected Human Macrophages Reduces the Viability of Intracellular Mycobacterium tuberculosis

Mauro Oddo, Toufic Renno, Antoine Attinger, Talitha Bakker, H. Robson MacDonald, and Pascal R. A. Meylan
J Immunol 1998 160: 5448-5454. [Abstract] [Full Text] [PDF]  

Treponema pallidum and Borrelia burgdorferi Lipoproteins and Synthetic Lipopeptides Activate Monocytic Cells via a CD14-Dependent Pathway Distinct from That Used by Lipopolysaccharide

Timothy J. Sellati, Deborah A. Bouis, Richard L. Kitchens, Richard P. Darveau, Jerome Pugin, Richard J. Ulevitch, Sophie C. Gangloff, Sanna M. Goyert, Michael V. Norgard, and Justin D. Radolf
J Immunol 1998 160: 5455-5464. [Abstract] [Full Text] [PDF]  

T Cell- and NK Cell-Independent Inhibition of Hepatic Metastases by Systemic Administration of an IL-12-Expressing Recombinant Adenovirus

William M. Siders, Paul W. Wright, Julie A. Hixon, W. Gregory Alvord, Timothy C. Back, Robert H. Wiltrout, and Robert G. Fenton
J Immunol 1998 160: 5465-5474. [Abstract] [Full Text] [PDF]  

IFN- Priming Up-Regulates IFN-Stimulated Gene Factor 3 (ISGF3) Components, Augmenting Responsiveness of IFN-Resistant Melanoma Cells to Type I IFNs

Lee H. Wong, Irene Hatzinisiriou, Rodney J. Devenish, and Stephen J. Ralph
J Immunol 1998 160: 5475-5484. [Abstract] [Full Text] [PDF]  

The Role of CD14 in Signaling Mediated by Outer Membrane Lipoproteins of Borrelia burgdorferi

R. Mark Wooten, Tom B. Morrison, John H. Weis, Samuel D. Wright, Rolf Thieringer, and Janis J. Weis
J Immunol 1998 160: 5485-5492. [Abstract] [Full Text] [PDF]  

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. II. FTY720 Prolongs Skin Allograft Survival by Decreasing T Cell Infiltration into Grafts But Not Cytokine Production In Vivo

Yoshiki Yanagawa, Kunio Sugahara, Hirotoshi Kataoka, Takafumi Kawaguchi, Yumi Masubuchi, and Kenji Chiba
J Immunol 1998 160: 5493-5499. [Abstract] [Full Text] [PDF]  

A Pathogenic Role of IL-12 in Blood-Stage Murine Malaria Lethal Strain Plasmodium berghei NK65 Infection

Takayuki Yoshimoto, Yasuhiro Takahama, Chrong-Reen Wang, Toshihiko Yoneto, Seiji Waki, and Hideo Nariuchi
J Immunol 1998 160: 5500-5505. [Abstract] [Full Text] [PDF]  

Control of Leishmania major Infection in Mice Lacking TNF Receptors

Michelle Nashleanas, Suzanne Kanaly, and Phillip Scott
J Immunol 1998 160: 5506-5513. [Abstract] [Full Text] [PDF]  

Nonopsonic and Opsonic Association of Mycobacterium tuberculosis with Resident Alveolar Macrophages Is Inefficient

Richard W. Stokes, Lisa M. Thorson, and David P. Speert
J Immunol 1998 160: 5514-5521. [Abstract] [Full Text] [PDF]  

Differential Requirement for CD4 Help in the Development of an Antigen-Specific CD8⁺ T Cell Response Depending on the Route of Immunization

Hélène Bour, Clotilde Horvath, Christophe Lurquin, Jean-Charles Cerottini, and H. Robson MacDonald
J Immunol 1998 160: 5522-5529. [Abstract] [Full Text] [PDF]  

Heparin-Binding Protein (CAP37) Is Internalized in Monocytes and Increases LPS-Induced Monocyte Activation

Michael Heinzelmann, Mark A. Mercer-Jones, Hans Flodgaard, and Frederick N. Miller
J Immunol 1998 160: 5530-5536. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

Reversible Expression of Tryptases and Chymases in the Jejunal Mast Cells of Mice Infected with Trichinella spiralis

Daniel S. Friend, Namit Ghildyal, Michael F. Gurish, John Hunt, Xuzhen Hu, K. Frank Austen, and Richard L. Stevens
J Immunol 1998 160: 5537-5545. [Abstract] [Full Text] [PDF]  

Sulfonylureas Inhibit Cytokine-Induced Eosinophil Survival and Activation

Jennifer L. Bankers-Fulbright, Gail M. Kephart, David A. Loegering, Annabel L. Bradford, Shinji Okada, Hirohito Kita, and Gerald J. Gleich
J Immunol 1998 160: 5546-5553. [Abstract] [Full Text] [PDF]  

Mast Cells Enhance Eosinophil Survival In Vitro: Role of TNF- and Granulocyte-Macrophage Colony-Stimulating Factor

Francesca Levi-Schaffer, Vladislav Temkin, Vivian Malamud, Sari Feld, and Yael Zilberman
J Immunol 1998 160: 5554-5562. [Abstract] [Full Text] [PDF]  

Cloning and Characterization of Mouse Vascular Adhesion Protein-1 Reveals a Novel Molecule with Enzymatic Activity

Petri Bono, Marko Salmi, David J. Smith, and Sirpa Jalkanen
J Immunol 1998 160: 5563-5571. [Abstract] [Full Text] [PDF]  

Human ß2-Glycoprotein I Binds to Endothelial Cells Through a Cluster of Lysine Residues That Are Critical for Anionic Phospholipid Binding and Offers Epitopes for Anti-ß2-Glycoprotein I Antibodies

N. Del Papa, Y. H. Sheng, E. Raschi, D. A. Kandiah, A. Tincani, M. A. Khamashta, T. Atsumi, G. R. V. Hughes, K. Ichikawa, T. Koike, G. Balestrieri, S. A. Krilis, and P. L. Meroni
J Immunol 1998 160: 5572-5578. [Abstract] [Full Text] [PDF]  

Coengagement of ICAM-3 and Fc Receptors Induces Chemokine Secretion and Spreading by Myeloid Leukocytes

Julie M. Kessel, Joel Hayflick, Andrew S. Weyrich, Patricia A. Hoffman, Michael Gallatin, Thomas M. McIntyre, Stephen M. Prescott, and Guy A. Zimmerman
J Immunol 1998 160: 5579-5587. [Abstract] [Full Text] [PDF]  

Prevention and Treatment of Experimental Autoimmune Encephalomyelitis by CNI-1493, a Macrophage-Deactivating Agent

James A. Martiney, Alice J. Rajan, Peter C. Charles, Anthony Cerami, Peter C. Ulrich, Stuart Macphail, Kevin J. Tracey, and Celia F. Brosnan
J Immunol 1998 160: 5588-5595. [Abstract] [Full Text] [PDF]  

Interaction of Vaccinia Virus Complement Control Protein with Human Complement Proteins: Factor I-Mediated Degradation of C3b to iC3b₁ Inactivates the Alternative Complement Pathway

Arvind Sahu, Stuart N. Isaacs, Athena M. Soulika, and John D. Lambris
J Immunol 1998 160: 5596-5604. [Abstract] [Full Text] [PDF]  

Potassium Leakage During the Apoptotic Degradation Phase

Bruno Dallaporta, Tamara Hirsch, Santos A. Susin, Naoufal Zamzami, Nathanael Larochette, Catherine Brenner, Isabel Marzo, and Guido Kroemer
J Immunol 1998 160: 5605-5615. [Abstract] [Full Text] [PDF]  

Novel C5a Receptor Antagonists Regulate Neutrophil Functions In Vitro and In Vivo

Theodore C. Pellas, William Boyar, Jan van Oostrum, James Wasvary, Lynn R. Fryer, Gary Pastor, Matthew Sills, Albert Braunwalder, Donna R. Yarwood, Richard Kramer, Earl Kimble, Joseph Hadala, William Haston, Rocio Moreira-Ludewig, Susan Uziel-Fusi, Paul Peters, Kurt Bill, and Lawrence P. Wennogle
J Immunol 1998 160: 5616-5621. [Abstract] [Full Text] [PDF]  

Differential Regulation of Chemoattractant-Stimulated ß₂, ß₃, and ß₇ Integrin Activity

Chanchal Sadhu, Boris Masinovsky, and Donald E. Staunton
J Immunol 1998 160: 5622-5628. [Abstract] [Full Text] [PDF]  

The Role of Two Distinct Endothelial Molecules, Vascular Adhesion Protein-1 and Peripheral Lymph Node Addressin, in the Binding of Lymphocyte Subsets to Human Lymph Nodes

Marko Salmi, Jukka Hellman, and Sirpa Jalkanen
J Immunol 1998 160: 5629-5636. [Abstract] [Full Text] [PDF]  

IL-4-Induced Eosinophil Accumulation in Rat Skin Is Dependent on Endogenous TNF- and ₄ Integrin/VCAM-1 Adhesion Pathways

Maria-Jesus Sanz, Lilia Marinova-Mutafchieva, Patricia Green, Roy R. Lobb, Marc Feldmann, and Sussan Nourshargh
J Immunol 1998 160: 5637-5645. [Abstract] [Full Text] [PDF]  

Receptors for the Anaphylatoxin C5a (CD88) on Human Mesangial Cells

W. A. Wilmer, P. T. Kaumaya, J. A. Ember, and F. G. Cosio
J Immunol 1998 160: 5646-5652. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

Soluble IL-15 Receptor -Chain Administration Prevents Murine Collagen-Induced Arthritis: A Role for IL-15 in Development of Antigen-Induced Immunopathology

Holger Ruchatz, Bernard P. Leung, Xiao-qing Wei, Iain B. McInnes, and Foo Y. Liew
J Immunol 1998 160: 5654-5660. [Abstract] [Full Text] [PDF]  

Theiler’s Virus Infection of Genetically Susceptible Mice Induces Central Nervous System-Infiltrating CTLs with no Apparent Viral or Major Myelin Antigenic Specificity

Xiaoqi Lin, Larry R. Pease, Paul D. Murray, and Moses Rodriguez
J Immunol 1998 160: 5661-5668. [Abstract] [Full Text] [PDF]  

The Fas Counterattack In Vivo: Apoptotic Depletion of Tumor-Infiltrating Lymphocytes Associated with Fas Ligand Expression by Human Esophageal Carcinoma

Michael W. Bennett, Joe O’Connell, Gerald C. O’Sullivan, Ciaran Brady, Desmond Roche, J. Kevin Collins, and Fergus Shanahan
J Immunol 1998 160: 5669-5675. [Abstract] [Full Text] [PDF]  

The Effect of Deletion of the V3 Loop of gp120 on Cytotoxic T Cell Responses and HIV gp120-Mediated Pathogenesis

Dariusz Kmieciak, Thomas J. Wasik, Hedy Teppler, Janet Pientka, Susan H. Hsu, Hidemi Takahashi, Ko Okumura, Yutaro Kaneko, and Danuta Kozbor
J Immunol 1998 160: 5676-5683. [Abstract] [Full Text] [PDF]  

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