CUTTING EDGE:

Cutting Edge: Involvement of SHP-2 in Multiple Aspects of IL-2 Signaling: Evidence for a Positive Regulatory Role

Massimo Gadina, Louis M. Stancato, Chris M. Bacon, Andrew C. Larner, and John J. O’Shea
J Immunol 1998 160: 4657-4661. [Abstract] [Full Text] [PDF]  

Cutting Edge: The B Cell Surface Protein CD72 Recruits the Tyrosine Phosphatase SHP-1 upon Tyrosine Phosphorylation

Takahiro Adachi, Heinrich Flaswinkel, Hidetaka Yakura, Michael Reth, and Takeshi Tsubata
J Immunol 1998 160: 4662-4665. [Abstract] [Full Text] [PDF]  

Cutting Edge: CD40 Ligation Prevents Neonatal Induction of Transplantation Tolerance

Véronique Flamand, Vincent Donckier, François-Xavier Demoor, Alain Le Moine, Patrick Matthys, Marie-Line Vanderhaeghen, Yoh-ichi Tagawa, Yoichiro Iwakura, Alfons Billiau, Daniel Abramowicz, and Michel Goldman
J Immunol 1998 160: 4666-4669. [Abstract] [Full Text] [PDF]  

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION:

Microglia Are More Efficient Than Astrocytes in Antigen Processing and in Th1 But Not Th2 Cell Activation

Francesca Aloisi, Francesco Ria, Giuseppe Penna, and Luciano Adorini
J Immunol 1998 160: 4671-4680. [Abstract] [Full Text] [PDF]  

T and B Cell Development in BP-1/6C3/Aminopeptidase A-Deficient Mice

Qun Lin, Ichiro Taniuchi, Daisuke Kitamura, Jiyang Wang, John F. Kearney, Takeshi Watanabe, and Max D. Cooper
J Immunol 1998 160: 4681-4687. [Abstract] [Full Text] [PDF]  

Kinetics of Establishing the Memory B Cell Population as Revealed by CD38 Expression

Anna Ridderstad and David M. Tarlinton
J Immunol 1998 160: 4688-4695. [Abstract] [Full Text] [PDF]  

DR/CLIP (Class II-Associated Invariant Chain Peptides) and DR/Peptide Complexes Colocalize in Prelysosomes in Human B Lymphoblastoid Cells

Espen Stang, Carolyn B. Guerra, Miguel Amaya, Yvonne Paterson, Oddmund Bakke, and Elizabeth D. Mellins
J Immunol 1998 160: 4696-4707. [Abstract] [Full Text] [PDF]  

In Situ Immune Response in Gut-Associated Lymphoid Tissue (GALT) Following Oral Antigen in TCR-Transgenic Mice

Patricia A. Gonnella, Youhai Chen, Jun-ichi Inobe, Yoshinori Komagata, Marc Quartulli, and Howard L. Weiner
J Immunol 1998 160: 4708-4718. [Abstract] [Full Text] [PDF]  

Direct Evidence That Functionally Impaired CD4⁺ T Cells Persist In Vivo Following Induction of Peripheral Tolerance

Kathryn A. Pape, Rebecca Merica, Anna Mondino, Alexander Khoruts, and Marc K. Jenkins
J Immunol 1998 160: 4719-4729. [Abstract] [Full Text] [PDF]  

Transplacental Priming of the Human Immune System to Environmental Allergens: Universal Skewing of Initial T Cell Responses Toward the Th2 Cytokine Profile

Susan L. Prescott, Claudia Macaubas, Barbara J. Holt, Troy B. Smallacombe, Richard Loh, Peter D. Sly, and Patrick G. Holt
J Immunol 1998 160: 4730-4737. [Abstract] [Full Text] [PDF]  

A Critical Role for IL-18 in the Proliferation and Activation of NK1.1⁺CD3^- Cells

Michio Tomura, Xu-Yu Zhou, Seiji Maruo, Hyun-Jong Ahn, Toshiyuki Hamaoka, Haruki Okamura, Kenji Nakanishi, Tadao Tanimoto, Masashi Kurimoto, and Hiromi Fujiwara
J Immunol 1998 160: 4738-4746. [Abstract] [Full Text] [PDF]  

Expression of Bright at Two Distinct Stages of B Lymphocyte Development

Carol F. Webb, Elizabeth A. Smith, Kay L. Medina, Kent L. Buchanan, Glennda Smithson, and Shenshen Dou
J Immunol 1998 160: 4747-4754. [Abstract] [Full Text] [PDF]  

CpG Motifs in Bacterial DNA Activate Leukocytes Through the pH-Dependent Generation of Reactive Oxygen Species

Ae-Kyung Yi, Rebecca Tuetken, Thomas Redford, Marianella Waldschmidt, Jeffrey Kirsch, and Arthur M. Krieg
J Immunol 1998 160: 4755-4761. [Abstract] [Full Text] [PDF]  

Pairing of Variable Heavy and Variable Chains in Individual Naive and Memory B Cells

Hans-Peter Brezinschek, Sandra J. Foster, Thomas Dörner, Ruth I. Brezinschek, and Peter E. Lipsky
J Immunol 1998 160: 4762-4767. [Abstract] [Full Text] [PDF]  

Differential Activation of T Cells by Natural Antigen Peptide Analogues: Influence on Autoimmune and Alloimmune In Vivo T Cell Responses

Luis R. B. Soares, Patricia L. Orr, Marvin R. Garovoy, and Gilles Benichou
J Immunol 1998 160: 4768-4775. [Abstract] [Full Text] [PDF]  

Enhanced B-1 Cell Development, But Impaired IgG Antibody Responses in Mice Deficient in Secreted IgM

Marianne Boes, Christine Esau, Michael B. Fischer, Tara Schmidt, Michael Carroll, and Jianzhu Chen
J Immunol 1998 160: 4776-4787. [Abstract] [Full Text] [PDF]  

Affinity Maturation in Lyn Kinase-Deficient Mice with Defective Germinal Center Formation

Jun Kato, Noboru Motoyama, Ichiro Taniuchi, Hiromichi Takeshita, Masaki Toyoda, Keiji Masuda, and Takeshi Watanabe
J Immunol 1998 160: 4788-4795. [Abstract] [Full Text] [PDF]  

Induction of Tolerance in B-1 Cells for Bromelain-Treated Mouse Red Blood Cells by a Transient Presence of Anti-Idiotype Antibodies in Neonatal and Adult Mice

Susumu Kawaguchi
J Immunol 1998 160: 4796-4800. [Abstract] [Full Text] [PDF]  

Flt3 Ligand Plus IL-7 Supports the Expansion of Murine Thymic B Cell Progenitors That Can Mature Intrathymically

Hilary J. McKenna and Philip J. Morrissey
J Immunol 1998 160: 4801-4809. [Abstract] [Full Text] [PDF]  

Consequences of Intrathymic TCR Engagement by Partial Agonist on Selection Events and Peripheral T Cell Activation Program

Nathalie Auphan, Anna Katharina Simon, Hélène Asnagli, Roderick J. Phillips, Mercedes Rincon, Sankar Ghosh, Richard A. Flavell, and Anne-Marie Schmitt-Verhulst
J Immunol 1998 160: 4810-4821. [Abstract] [Full Text] [PDF]  

A Critical Role for IL-4 in Regulating Disease Severity in Experimental Allergic Encephalomyelitis as Demonstrated in IL-4-Deficient C57BL/6 Mice and BALB/c Mice

Marika Falcone, Alice J. Rajan, Barry R. Bloom, and Celia F. Brosnan
J Immunol 1998 160: 4822-4830. [Abstract] [Full Text] [PDF]  

Activated Rat Macrophages Produce a Galectin-1-Like Protein That Induces Apoptosis of T Cells: Biochemical and Functional Characterization

Gabriel A. Rabinovich, María M. Iglesias, Nidia M. Modesti, Leonardo F. Castagna, Carlota Wolfenstein-Todel, Clelia M. Riera, and Claudia E. Sotomayor
J Immunol 1998 160: 4831-4840. [Abstract] [Full Text] [PDF]  

Partial TCR Signals Delivered by FcR-Nonbinding Anti-CD3 Monoclonal Antibodies Differentially Regulate Individual Th Subsets

Judith A. Smith, Qizhi Tang, and Jeffrey A. Bluestone
J Immunol 1998 160: 4841-4849. [Abstract] [Full Text] [PDF]  

Phosphorylation Regulates the Delivery of MHC Class II Invariant Chain Complexes to Antigen Processing Compartments

Howard A. Anderson and Paul A. Roche
J Immunol 1998 160: 4850-4858. [Abstract] [Full Text] [PDF]  

Dissociation of Proteasomal Degradation of Biosynthesized Viral Proteins from Generation of MHC Class I-Associated Antigenic Peptides

Luis C. Antón, Heidi L. Snyder, Jack R. Bennink, Alexander Vinitsky, Marian Orlowski, Angel Porgador, and Jonathan W. Yewdell
J Immunol 1998 160: 4859-4868. [Abstract] [Full Text] [PDF]  

Modulation of T Cell Cytokine Profiles and Peptide-MHC Complex Availability In Vivo by Delivery to Scavenger Receptors via Antigen Maleylation

Nagendra Singh, Sumeena Bhatia, Roshini Abraham, Sandip K. Basu, Anna George, Vineeta Bal, and Satyajit Rath
J Immunol 1998 160: 4869-4880. [Abstract] [Full Text] [PDF]  

Phosphorylation of FADD/MORT1 and Fas by Kinases That Associate with the Membrane-Proximal Cytoplasmic Domain of Fas

Norman J. Kennedy and Ralph C. Budd
J Immunol 1998 160: 4881-4888. [Abstract] [Full Text] [PDF]  

Respiratory Syncytial Virus-Infected Pulmonary Epithelial Cells Induce Eosinophil Degranulation by a CD18-Mediated Mechanism

Barbara Olszewska-Pazdrak, Konrad Pazdrak, Pearay L. Ogra, and Roberto P. Garofalo
J Immunol 1998 160: 4889-4895. [Abstract] [Full Text] [PDF]  

MOLECULAR AND STRUCTURAL IMMUNOLOGY:

3' IgH Enhancer Elements Shift Synergistic Interactions During B Cell Development

Jane Ong, Sean Stevens, Robert G. Roeder, and Laurel A. Eckhardt
J Immunol 1998 160: 4896-4903. [Abstract] [Full Text] [PDF]  

Rearrangement and Selection in the Developing V Repertoire of the Mouse: An Analysis of the Usage of Two V Gene Segments

Elizabeth A. Whitcomb and Peter H. Brodeur
J Immunol 1998 160: 4904-4913. [Abstract] [Full Text] [PDF]  

Activation of the CD2 Pathway in Lamina Propria T Cells Up-Regulates Functionally Active AP-1 Binding to the IL-2 Promoter, Resulting in Messenger RNA Transcription and IL-2 Secretion

Rivkah Gonsky, Richard L. Deem, Christopher C. W. Hughes, and Stephan R. Targan
J Immunol 1998 160: 4914-4922. [Abstract] [Full Text] [PDF]  

Characterization of the Mouse PA28 Activator Complex Gene Family: Complete Organizations of the Three Member Genes and a Physical Map of the 150-kb Region Containing the - and ß-Subunit Genes

Keiko Kohda, Teruo Ishibashi, Naoki Shimbara, Keiji Tanaka, Yoichi Matsuda, and Masanori Kasahara
J Immunol 1998 160: 4923-4935. [Abstract] [Full Text] [PDF]  

Polymorphism in the I₁ Germ-Line Transcript Regulatory Region and IgA Productivity in Patients with IgA Nephropathy

Naohiro Yano, Kumiko Asakura, Masayuki Endoh, Yoshifumi Abe, Yasuo Nomoto, Hideto Sakai, Kiyoshi Kurokawa, and Hideo Tsukamoto
J Immunol 1998 160: 4936-4942. [Abstract] [Full Text] [PDF]  

The Structure of Avian CD5 Implies a Conserved Function

Riitta Koskinen, Thomas W. F. Göbel, Clive A. Tregaskes, John R. Young, and Olli Vainio
J Immunol 1998 160: 4943-4950. [Abstract] [Full Text] [PDF]  

HLA-E Surface Expression Depends on Binding of TAP-Dependent Peptides Derived from Certain HLA Class I Signal Sequences

Ni Lee, David R. Goodlett, Akiko Ishitani, Hans Marquardt, and Daniel E. Geraghty
J Immunol 1998 160: 4951-4960. [Abstract] [Full Text] [PDF]  

Molecular Mechanisms of Inducible Nitric Oxide Synthase Gene Expression by IL-1ß and cAMP in Rat Mesangial Cells

Wolfgang Eberhardt, Christoph Plüss, Richard Hummel, and Josef Pfeilschifter
J Immunol 1998 160: 4961-4969. [Abstract] [Full Text] [PDF]  

Posttranscriptional Lipopolysaccharide Regulation of the Lysozyme Gene at Processing of the Primary Transcript in Myelomonocytic HD11 Cells

Ralph Goethe and Loc Phi-van
J Immunol 1998 160: 4970-4978. [Abstract] [Full Text] [PDF]  

Phosphatidylinositol 3'-Kinase and SH2-Containing Inositol Phosphatase (SHIP) Are Recruited by Distinct Positive and Negative Growth-Regulatory Domains in the Granulocyte Colony-Stimulating Factor Receptor

Melissa G. Hunter and Belinda R. Avalos
J Immunol 1998 160: 4979-4987. [Abstract] [Full Text] [PDF]  

Purification and Characterization of Lymphocyte Chymase I, a Granzyme Implicated in Perforin-Mediated Lysis

Susan L. Woodard, Stephanie A. Fraser, Ulrike Winkler, Delwin S. Jackson, Chih-Min Kam, James C. Powers, and Dorothy Hudig
J Immunol 1998 160: 4988-4993. [Abstract] [Full Text] [PDF]  

HOST DEFENSE:

Localization and Regulation of IFN- Production Within the Granulomas of Murine Schistosomiasis in IL-4-Deficient and Control Mice

Eva Rakasz, Arthur M. Blum, Ahmed Metwali, David E. Elliott, Jie Li, Zuhair K. Ballas, Khurram Qadir, Richard Lynch, and Joel V. Weinstock
J Immunol 1998 160: 4994-4999. [Abstract] [Full Text] [PDF]  

Cellular Mechanism of Intraabdominal Abscess Formation by Bacteroides fragilis

Frank C. Gibson, III, Andrew B. Onderdonk, Dennis L. Kasper, and Arthur O. Tzianabos
J Immunol 1998 160: 5000-5006. [Abstract] [Full Text] [PDF]  

CD4⁺ and CD8⁺ T Cell Interactions in IFN- and IL-4 Responses to Viral Infections: Requirements for IL-2

Helen C. Su, Leslie P. Cousens, Loren D. Fast, Mark K. Slifka, Richard D. Bungiro, Rafi Ahmed, and Christine A. Biron
J Immunol 1998 160: 5007-5017. [Abstract] [Full Text] [PDF]  

CBL-GRB2 Interaction in Myeloid Immunoreceptor Tyrosine Activation Motif Signaling

Rae Kil Park, Wade T. Kyono, Yenbou Liu, and Donald L. Durden
J Immunol 1998 160: 5018-5027. [Abstract] [Full Text] [PDF]  

Bactericidal Monoclonal Antibodies That Define Unique Meningococcal B Polysaccharide Epitopes That Do Not Cross-React with Human Polysialic Acid

Dan M. Granoff, Antonella Bartoloni, Stefano Ricci, Eugenia Gallo, Domenico Rosa, Neil Ravenscroft, Valentina Guarnieri, Robert C. Seid, Asra Shan, William R. Usinger, Siqi Tan, Yvonne E. McHugh, and Gregory R. Moe
J Immunol 1998 160: 5028-5036. [Abstract] [Full Text] [PDF]  

INFLAMMATION:

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

Kenji Chiba, Yoshiki Yanagawa, Yumi Masubuchi, Hirotoshi Kataoka, Takafumi Kawaguchi, Makio Ohtsuki, and Yukio Hoshino
J Immunol 1998 160: 5037-5044. [Abstract] [Full Text] [PDF]  

B7 Costimulatory Requirements of T Cells at an Inflammatory Site

Haixiao Chen and Robert L. Hendricks
J Immunol 1998 160: 5045-5052. [Abstract] [Full Text] [PDF]  

Human Mast Cells Augment Fibroblast Proliferation by Heterotypic Cell-Cell Adhesion and Action of IL-4

Axel Trautmann, Georg Krohne, Eva-B. Bröcker, and C. Eberhard Klein
J Immunol 1998 160: 5053-5057. [Abstract] [Full Text] [PDF]  

Functional Mapping of CD11b/CD18 Epitopes Important in Neutrophil-Epithelial Interactions: A Central Role of the I Domain

Leora B. Balsam, Tony W. Liang, and Charles A. Parkos
J Immunol 1998 160: 5058-5065. [Abstract] [Full Text] [PDF]  

Synergistic Effect of Type II Phospholipase A₂ and Platelet-Activating Factor on Mac-1 Surface Expression and Exocytosis of Gelatinase Granules in Human Neutrophils: Evidence for the 5-Lipoxygenase-Dependent Mechanism

Jun Takasaki, Yasushi Kawauchi, and Yasuhiko Masuho
J Immunol 1998 160: 5066-5072. [Abstract] [Full Text] [PDF]  

Expression of Receptors for C5a Anaphylatoxin (CD88) on Human Bronchial Epithelial Cells: Enhancement of C5a-Mediated Release of IL-8 upon Exposure to Cigarette Smoke

Anthony A. Floreani, Art J. Heires, Lisbeth A. Welniak, Amanda Miller-Lindholm, Laurel Clark-Pierce, Stephen I. Rennard, Edward L. Morgan, and Sam D. Sanderson
J Immunol 1998 160: 5073-5081. [Abstract] [Full Text] [PDF]  

Staphylococcus aureus-Induced Septic Arthritis and Septic Death Is Decreased in IL-4-Deficient Mice: Role of IL-4 as Promoter for Bacterial Growth

Olof Hultgren, Manfred Kopf, and Andrzej Tarkowski
J Immunol 1998 160: 5082-5087. [Abstract] [Full Text] [PDF]  

Escherichia coli Bound to the Primate Erythrocyte Complement Receptor via Bispecific Monoclonal Antibodies Are Transferred to and Phagocytosed by Human Monocytes in an In Vitro Model

Susan E. Kuhn, Alessandra Nardin, Philip E. Klebba, and Ronald P. Taylor
J Immunol 1998 160: 5088-5097. [Abstract] [Full Text] [PDF]  

Regulation of TNF- Production in Activated Mouse Macrophages by Progesterone

Lance Miller and Joan S. Hunt
J Immunol 1998 160: 5098-5104. [Abstract] [Full Text] [PDF]  

IFN--Deficient Mice Develop Severe Granulomatous Experimental Autoimmune Thyroiditis with Eosinophil Infiltration in Thyroids

Haiwen Tang, Gordon C. Sharp, Karin P. Peterson, and Helen Braley-Mullen
J Immunol 1998 160: 5105-5112. [Abstract] [Full Text] [PDF]  

Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways

Mimi L. K. Tang, Douglas A. Steeber, Xiu-Qin Zhang, and Thomas F. Tedder
J Immunol 1998 160: 5113-5121. [Abstract] [Full Text] [PDF]  

An sLex-Deficient Variant of HL60 Cells Exhibits High Levels of Adhesion to Vascular Selectins: Further Evidence That HECA-452 and CSLEX1 Monoclonal Antibody Epitopes Are Not Essential for High Avidity Binding to Vascular Selectins

Amy J. Wagers, Lloyd M. Stoolman, Ron Craig, Randall N. Knibbs, and Geoffrey S. Kansas
J Immunol 1998 160: 5122-5129. [Abstract] [Full Text] [PDF]  

Potential Mechanisms for a Proinflammatory Vascular Cytokine Response to Coagulation Activation

Kirk Johnson, Yoon Choi, Els DeGroot, Isa Samuels, Abla Creasey, and Lucien Aarden
J Immunol 1998 160: 5130-5135. [Abstract] [Full Text] [PDF]  

Quercetin Sensitizes RBL-2H3 Cells to Polybasic Mast Cell Secretagogues Through Increased Expression of G_i GTP-Binding Proteins Linked to a Phospholipase C Signaling Pathway

Jan Senyshyn, Rudolf A. Baumgartner, and Michael A. Beaven
J Immunol 1998 160: 5136-5144. [Abstract] [Full Text] [PDF]  

IFN- Is Produced by Polymorphonuclear Neutrophils in Human Uterine Endometrium and by Cultured Peripheral Blood Polymorphonuclear Neutrophils

Grant R. Yeaman, Jane E. Collins, Janet K. Currie, Paul M. Guyre, Charles R. Wira, and Michael W. Fanger
J Immunol 1998 160: 5145-5153. [Abstract] [Full Text] [PDF]  

Syk Activation Is Required for Spreading and H₂O₂ Release in Adherent Human Neutrophils

Rosemarie Fernandez and Suzanne J. Suchard
J Immunol 1998 160: 5154-5162. [Abstract] [Full Text] [PDF]  

TGF-ß1 as an Endogenous Defender Against Macrophage-Triggered Stromelysin Gene Expression in the Glomerulus

Masanori Kitamura
J Immunol 1998 160: 5163-5168. [Abstract] [Full Text] [PDF]  

CLINICAL IMMUNOLOGY:

In Vivo Effects of a Bacterial Superantigen on Macaque TCR Repertoires

Zhong-Chen Kou, Matilda Halloran, David Lee-Parritz, Ling Shen, Meredith Simon, Prabhat K. Sehgal, Yun Shen, and Zheng W. Chen
J Immunol 1998 160: 5170-5180. [Abstract] [Full Text] [PDF]  

Cytokine Gene Therapy in Experimental Allergic Encephalomyelitis by Injection of Plasmid DNA-Cationic Liposome Complex into the Central Nervous System

J. Ludovic Croxford, Kostas Triantaphyllopoulos, Osvaldo L. Podhajcer, Marc Feldmann, David Baker, and Yuti Chernajovsky
J Immunol 1998 160: 5181-5187. [Abstract] [Full Text] [PDF]  

Short Peptide-Based Tolerogens Without Self-Antigenic or Pathogenic Activity Reverse Autoimmune Disease

Nathan Karin, Ofer Binah, Nir Grabie, Dennis J. Mitchell, Bella Felzen, Matthew D. Solomon, Paul Conlon, Amitabh Gaur, Nicholas Ling, and Lawrence Steinman
J Immunol 1998 160: 5188-5194. [Abstract] [Full Text] [PDF]  

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