- Received September 6, 2016.
- Accepted November 21, 2016.
- Published online December 21, 2016.
- Kenji Chamoto*,1,
- Tingxi Guo*,†,1,
- Stephen W. Scally‡,
- Yuki Kagoya*,
- Mark Ancruzowski*,†,
- Chung-Hsi Wang*,†,
- Muhammed A. Rahman*,
- Kayoko Saso*,
- Marcus O. Butler*,†,§,
- Priscilla P. L. Chiu¶,‖,
- Jean-Philippe Julien†,‡,# and
- Naoto Hirano*,†
- *Tumor Immunotherapy Program, Campbell Family Institute for Breast Cancer Research, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2M9, Canada;
- †Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada;
- ‡Program in Molecular Structure and Function, The Hospital for Sick Children Research Institute, Toronto, Ontario M5G 0A4, Canada;
- §Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada;
- ¶Division of Pediatric Surgery, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada;
- ‖Department of Surgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada; and
- #Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
- Address correspondence and reprint requests to Dr. Naoto Hirano, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, ON M5G 2M9, Canada. E-mail address:
↵1 K.C. and T.G. contributed equally to this work.
K.C., T.G., and N.H. designed the project; K.C., T.G., Y.K., M.A., C.-H.W., M.A.R., and K.S. performed experiments; S.W.S. and J.-P.J. designed and performed the molecular dynamics modeling and contributed to the writing of the manuscript; M.O.B. and P.P.L.C. provided human samples; K.C., T.G., and N.H. analyzed the results; and T.G. and N.H. wrote the manuscript.