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Antigenicity of the M Proteins of Group A Hemolytic Streptococci

II. Antibody Response in Rabbits to Vaccines Prepared with Oil Emulsions and Aluminum Hydroxide

Eugene N. Fox and M. K. Wittner
J Immunol July 1, 1966, 97 (1) 86-94;
Eugene N. Fox
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M. K. Wittner
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Summary

Highly purified M proteins have excellent antigenic capacities in rabbits when administered in the form of repository subcutaneous doses with adjuvants. Both mineral oil and peanut oil emulsions prepared with Arlacel A and as little as 10 µg of M protein, after two or three injections, stimulated type-specific protective antibodies. Small doses of M proteins adsorbed to aluminum hydroxide were equally efficacious preparations for vaccine purposes. The attributes of these immunization procedures are discussed in terms of a practical antistreptococcal vaccine for human use. The globulin nature of the antibodies induced in rabbits immunized with purified M proteins or whole bacterial cells was also investigated. Both types of antigenic stimulation induced IgG antibodies but with different precipitating and hemagglutinating capacities.

Footnotes

  • ↵1 This work was supported by grants AI-04342 and AI-05996 from the National Institutes of Health and from The National Foundation.

  • Received February 11, 1966.
  • Copyright © 1966 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 97, Issue 1
1 Jul 1966
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Antigenicity of the M Proteins of Group A Hemolytic Streptococci
Eugene N. Fox, M. K. Wittner
The Journal of Immunology July 1, 1966, 97 (1) 86-94;

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Antigenicity of the M Proteins of Group A Hemolytic Streptococci
Eugene N. Fox, M. K. Wittner
The Journal of Immunology July 1, 1966, 97 (1) 86-94;
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Print ISSN 0022-1767        Online ISSN 1550-6606