The variations in host response to controlled experimental infections have always offered a problem worthy of detailed investigation. The need for such investigation becomes increasingly important when such experimental infections form the basis for estimating the therapeutic efficiency of various antisera used in the treatment of specific bacterial infections. Thus in the course of studies on pneumococcus infection in rabbits after the method of Zinsser (1) and Goodner (2) it soon became apparent that the susceptibility of animals when measured by such factors as the size of the local lesion and the degree of blood stream invasion, varied within extremely wide limits, following upon injection of a relatively constant intradermal dose of virulent type I pneumococci. It was felt that a more detailed study of these experimental infections might throw some light on the question of host susceptibility.
- Received June 4, 1934.
- Copyright, 1935, by The Williams & Wilkins Company
- Copyright © 1935 by The American Association of Immunologists, Inc.