On the cover: Immunomodulatory PRMT5 inhibitor HLCL65 binding to PRMT5 enzyme. Docked HLCL65 molecule is represented in green. PRMT5's α-helix, β-sheets, and turns are colored pink, yellow and grey, respectively. S-adenosyl methionine analog is shown in orange, and histone H4 peptide with substrate Arg3 residue is shown in cyan. Webb, L. M., S. A. Amici, K. A. Jablonski, H. Savardekar, A. R. Panfil, L. Li, W. Zhou, K. Peine, V. Karkhanis, E. M. Bachelder, K. M. Ainslie, P. L. Green, C. Li, R. A. Baiocchi, and M. Guerau-de-Arellano. 2017. PRMT5 selective inhibitors suppress inflammatory T cell responses and experimental autoimmune encephalomyelitis. J. Immunol. 197: 1439–1451.