The Journal of Immunology: 197 (12)

December 15, 2016; Volume 197,Issue 12

IN THIS ISSUE

You have accessRestricted access
In This Issue
A Grave Warning from a Mouse Model of Spontaneous Autoimmunity See article p. 4560
Scavenging Surfactant To Support TB See article p. 4727
PTPN22 Polices Kinase Phosphorylation in PMNs See article p. 4771
Mediating Complement Activation Free from mAb Fc See article p. 4829

J Immunol December 15, 2016, 197 (12) 4507-4508; DOI: https://doi.org/10.4049/jimmunol.1690020

BRIEF REVIEWS

You have accessRestricted access
Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System
Charles F. Spurlock, Philip S. Crooke and Thomas M. Aune

J Immunol December 15, 2016, 197 (12) 4509-4517; DOI: https://doi.org/10.4049/jimmunol.1600970
You have accessRestricted access
The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria
Marcela Montes de Oca, Michael F. Good, James S. McCarthy and Christian R. Engwerda

J Immunol December 15, 2016, 197 (12) 4518-4526; DOI: https://doi.org/10.4049/jimmunol.1600619

CUTTING EDGE

You have accessRestricted access
Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
Shaun W. Jackson, Nicole E. Scharping, Holly M. Jacobs, Shari Wang, Alan Chait and David J. Rawlings

J Immunol December 15, 2016, 197 (12) 4529-4534; DOI: https://doi.org/10.4049/jimmunol.1601198
You have accessRestricted access
Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes
Tianyu He, Egidio Brocca-Cofano, Benjamin B. Policicchio, Ranjit Sivanandham, Rajeev Gautam, Kevin D. Raehtz, Cuiling Xu, Ivona Pandrea and Cristian Apetrei

J Immunol December 15, 2016, 197 (12) 4535-4539; DOI: https://doi.org/10.4049/jimmunol.1601539

ALLERGY AND OTHER HYPERSENSITIVITIES

You have accessRestricted access
STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response to Alternaria alternata
Andrea C. Valladao, Charles W. Frevert, Lisa K. Koch, Daniel J. Campbell and Steven F. Ziegler

J Immunol December 15, 2016, 197 (12) 4541-4551; DOI: https://doi.org/10.4049/jimmunol.1600007

AUTOIMMUNITY

You have accessRestricted access
IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI
Esil Aleyd, Marjon Al, Cornelis W. Tuk, Conny J. van der Laken and Marjolein van Egmond

J Immunol December 15, 2016, 197 (12) 4552-4559; DOI: https://doi.org/10.4049/jimmunol.1502353
You have accessRestricted access
Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans
Basil Rapoport, Bianca Banuelos, Holly A. Aliesky, Nicole Hartwig Trier and Sandra M. McLachlan

J Immunol December 15, 2016, 197 (12) 4560-4568; DOI: https://doi.org/10.4049/jimmunol.1601393
You have accessRestricted access
Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide
Jeoung-Eun Park, Jeffrey A. Rotondo, David L. Cullins, David D. Brand, Ae-Kyung Yi, John M. Stuart, Andrew H. Kang and Linda K. Myers

J Immunol December 15, 2016, 197 (12) 4569-4575; DOI: https://doi.org/10.4049/jimmunol.1600771
You have accessRestricted access
Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
Nele Claes, Judith Fraussen, Marjan Vanheusden, Niels Hellings, Piet Stinissen, Bart Van Wijmeersch, Raymond Hupperts and Veerle Somers

J Immunol December 15, 2016, 197 (12) 4576-4583; DOI: https://doi.org/10.4049/jimmunol.1502448

CLINICAL AND HUMAN IMMUNOLOGY

You have accessRestricted access
CD8αβ⁺ γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease
Mohammad Kadivar, Julia Petersson, Lena Svensson and Jan Marsal

J Immunol December 15, 2016, 197 (12) 4584-4592; DOI: https://doi.org/10.4049/jimmunol.1601146
You have accessRestricted access
First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
Nicolas Poirier, Gilles Blancho, Maryvonne Hiance, Caroline Mary, Tim Van Assche, Jos Lempoels, Steven Ramael, Weirong Wang, Virginie Thepenier, Cecile Braudeau, Nina Salabert, Regis Josien, Ian Anderson, Ian Gourley, Jean-Paul Soulillou, Didier Coquoz and Bernard Vanhove

J Immunol December 15, 2016, 197 (12) 4593-4602; DOI: https://doi.org/10.4049/jimmunol.1601538
You have accessRestricted access
Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects
Yunda Huang, Guido Ferrari, Galit Alter, Donald N. Forthal, John C. Kappes, George K. Lewis, J. Christopher Love, Bhavesh Borate, Linda Harris, Kelli Greene, Hongmei Gao, Tran B. Phan, Gary Landucci, Brittany A. Goods, Karen G. Dowell, Hao D. Cheng, Chris Bailey-Kellogg, David C. Montefiori and Margaret E. Ackerman

J Immunol December 15, 2016, 197 (12) 4603-4612; DOI: https://doi.org/10.4049/jimmunol.1601197

IMMUNE REGULATION

You have accessRestricted access
The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83⁺-Activated T Cell Population
Xinsheng Ju, Pablo A. Silveira, Wei-Hsun Hsu, Zehra Elgundi, Renz Alingcastre, Nirupama D. Verma, Phillip D. Fromm, Jennifer L. Hsu, Christian Bryant, Ziduo Li, Fiona Kupresanin, Tsun-Ho Lo, Candice Clarke, Kenneth Lee, Helen McGuire, Barbara Fazekas de St. Groth, Stephen R. Larsen, John Gibson, Kenneth F. Bradstock, Georgina J. Clark and Derek N. J. Hart

J Immunol December 15, 2016, 197 (12) 4613-4625; DOI: https://doi.org/10.4049/jimmunol.1600339
You have accessRestricted access
Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma
Anitha Krishnan, Fei Fei, Alexander Jones, Patricia Busto, Ann Marshak-Rothstein, Bruce R. Ksander and Meredith Gregory-Ksander

J Immunol December 15, 2016, 197 (12) 4626-4638; DOI: https://doi.org/10.4049/jimmunol.1601488
Open Access
The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis
Author Choice Article

Takashi Izawa, Rieko Arakaki, Hiroki Mori, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka and Naozumi Ishimaru

J Immunol December 15, 2016, 197 (12) 4639-4650; DOI: https://doi.org/10.4049/jimmunol.1600822
You have accessRestricted access
Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses
Noah Alberts-Grill, Daniel Engelbertsen, Dexiu Bu, Amanda Foks, Nir Grabie, Jan M. Herter, Felicia Kuperwaser, Tao Chen, Gina Destefano, Petr Jarolim and Andrew H. Lichtman

J Immunol December 15, 2016, 197 (12) 4651-4662; DOI: https://doi.org/10.4049/jimmunol.1600206

IMMUNOTHERAPY AND VACCINES

You have accessRestricted access
HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism
Todd Bradley, Guang Yang, Olga Ilkayeva, T. Matt Holl, Ruijun Zhang, Jinsong Zhang, Sampa Santra, Christopher B. Fox, Steve G. Reed, Robert Parks, Cindy M. Bowman, Hilary Bouton-Verville, Laura L. Sutherland, Richard M. Scearce, Nathan Vandergrift, Thomas B. Kepler, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Roger McLendon, Jeffrey I. Everitt, Christopher B. Newgard, Laurent Verkoczy, Garnett Kelsoe and Barton F. Haynes

J Immunol December 15, 2016, 197 (12) 4663-4673; DOI: https://doi.org/10.4049/jimmunol.1601484
You have accessRestricted access
Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell–Treated Mice
Marie-Louise Sentman, Joana M. Murad, W. James Cook, Ming-Ru Wu, Jake Reder, Susanne H. Baumeister, Glenn Dranoff, Michael W. Fanger and Charles L. Sentman

J Immunol December 15, 2016, 197 (12) 4674-4685; DOI: https://doi.org/10.4049/jimmunol.1600769

INFECTIOUS DISEASE AND HOST RESPONSE

You have accessRestricted access
Mucosal and Systemic γδ⁺ T Cells Associated with Control of Simian Immunodeficiency Virus Infection
Iskra Tuero, David Venzon and Marjorie Robert-Guroff

J Immunol December 15, 2016, 197 (12) 4686-4695; DOI: https://doi.org/10.4049/jimmunol.1600579
You have accessRestricted access
Identification of an Activating Chicken Ig-like Receptor Recognizing Avian Influenza Viruses
Christine A. Jansen, Daphne A. van Haarlem, Beatrice Sperling, Peter J. van Kooten, Erik de Vries, Birgit C. Viertlboeck, Lonneke Vervelde and Thomas W. Göbel

J Immunol December 15, 2016, 197 (12) 4696-4703; DOI: https://doi.org/10.4049/jimmunol.1600401
You have accessRestricted access
Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA
Junyong Wang, Cao-Qi Lei, Yanhong Ji, Hongbo Zhou, Yujie Ren, Qianqian Peng, Yan Zeng, Yane Jia, Jinying Ge, Bo Zhong, Yu Li, Jianzhong Wei, Hong-Bing Shu and Qiyun Zhu

J Immunol December 15, 2016, 197 (12) 4704-4713; DOI: https://doi.org/10.4049/jimmunol.1502317
You have accessRestricted access
Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling
Author Choice Article

Lúcia Moreira-Teixeira, Jeremy Sousa, Finlay W. McNab, Egídio Torrado, Filipa Cardoso, Henrique Machado, Flávia Castro, Vânia Cardoso, Joana Gaifem, Xuemei Wu, Rui Appelberg, António Gil Castro, Anne O’Garra and Margarida Saraiva

J Immunol December 15, 2016, 197 (12) 4714-4726; DOI: https://doi.org/10.4049/jimmunol.1600584
You have accessRestricted access
CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
Claire E. Dodd, Charlie J. Pyle, Rebecca Glowinski, Murugesan V. S. Rajaram and Larry S. Schlesinger

J Immunol December 15, 2016, 197 (12) 4727-4735; DOI: https://doi.org/10.4049/jimmunol.1600856

INNATE IMMUNITY AND INFLAMMATION

You have accessRestricted access
Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7
Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu and Wuhan Xiao

J Immunol December 15, 2016, 197 (12) 4736-4749; DOI: https://doi.org/10.4049/jimmunol.1601187
You have accessRestricted access
Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
Xingyu Wang, Wanming Zhao, Richard M. Ransohoff and Lan Zhou

J Immunol December 15, 2016, 197 (12) 4750-4761; DOI: https://doi.org/10.4049/jimmunol.1601308
You have accessRestricted access
Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity
Yuan-Hua Chen, Xiao-Guang Hu, Yan Zhou, Zhen Yu, Lin Fu, Gui-Bin Zhang, Qing-Li Bo, Hua Wang, Cheng Zhang and De-Xiang Xu

J Immunol December 15, 2016, 197 (12) 4762-4770; DOI: https://doi.org/10.4049/jimmunol.1601331
You have accessRestricted access
PTPN22 Is a Critical Regulator of Fcγ Receptor–Mediated Neutrophil Activation
Author Choice Article

Sonja Vermeren, Katherine Miles, Julia Y. Chu, Donald Salter, Rose Zamoyska and Mohini Gray

J Immunol December 15, 2016, 197 (12) 4771-4779; DOI: https://doi.org/10.4049/jimmunol.1600604
You have accessRestricted access
Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish
Emily E. Rosowski, Qing Deng, Nancy P. Keller and Anna Huttenlocher

J Immunol December 15, 2016, 197 (12) 4780-4790; DOI: https://doi.org/10.4049/jimmunol.1600928
You have accessRestricted access
Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences
Gael Auray, Irene Keller, Sylvie Python, Markus Gerber, Remy Bruggmann, Nicolas Ruggli and Artur Summerfield

J Immunol December 15, 2016, 197 (12) 4791-4806; DOI: https://doi.org/10.4049/jimmunol.1600672

MOLECULAR AND STRUCTURAL IMMUNOLOGY

You have accessRestricted access
Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu¹⁸⁰ and Arg²³⁹
Christoffer Dellgren, Vanessa A. C. Ekwelum, Maria Ormhøj, Nicole Pallesen, Julie Knudsen, Jan O. Nehlin and Torben Barington

J Immunol December 15, 2016, 197 (12) 4807-4816; DOI: https://doi.org/10.4049/jimmunol.1502546

SYSTEMS IMMUNOLOGY

You have accessRestricted access
Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection
Hannah P. Gideon, Jason A. Skinner, Nicole Baldwin, JoAnne L. Flynn and Philana Ling Lin

J Immunol December 15, 2016, 197 (12) 4817-4828; DOI: https://doi.org/10.4049/jimmunol.1601138

TUMOR IMMUNOLOGY

You have accessRestricted access
Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
Patrick J. Engelberts, Marleen Voorhorst, Janine Schuurman, Tom van Meerten, Joost M. Bakker, Tom Vink, Wendy J. M. Mackus, Esther C. W. Breij, Stefanie Derer, Thomas Valerius, Jan G. J. van de Winkel, Paul W. H. I. Parren and Frank J. Beurskens

J Immunol December 15, 2016, 197 (12) 4829-4837; DOI: https://doi.org/10.4049/jimmunol.1600811

NOVEL IMMUNOLOGICAL METHODS

You have accessRestricted access
Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs
Joao N. Duarte, Juan J. Cragnolini, Lee Kim Swee, Angelina M. Bilate, Justin Bader, Jessica R. Ingram, Ali Rashidfarrokhi, Tao Fang, Ariën Schiepers, Leo Hanke and Hidde L. Ploegh

J Immunol December 15, 2016, 197 (12) 4838-4847; DOI: https://doi.org/10.4049/jimmunol.1600692
You have accessRestricted access
Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells
Maude Boisvert, Wanrui Zhang, Elizabeth J. Elrod, Nicole F. Bernard, Jean-Pierre Villeneuve, Julie Bruneau, Joseph Marcotrigiano, Naglaa H. Shoukry and Arash Grakoui

J Immunol December 15, 2016, 197 (12) 4848-4858; DOI: https://doi.org/10.4049/jimmunol.1600763

LETTERS OF RETRACTION

You have accessRestricted access
Retraction: Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
J Immunol December 15, 2016, 197 (12) 4859; DOI: https://doi.org/10.4049/jimmunol.1601800
You have accessRestricted access
Retraction: Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells
J Immunol December 15, 2016, 197 (12) 4860; DOI: https://doi.org/10.4049/jimmunol.1601801

CORRECTIONS

You have accessRestricted access
Correction: In This Issue
J Immunol December 15, 2016, 197 (12) 4861; DOI: https://doi.org/10.4049/jimmunol.1601794

Main menu

User menu

Search

Table of Contents

IN THIS ISSUE

BRIEF REVIEWS

CUTTING EDGE

ALLERGY AND OTHER HYPERSENSITIVITIES

AUTOIMMUNITY

CLINICAL AND HUMAN IMMUNOLOGY

IMMUNE REGULATION

IMMUNOTHERAPY AND VACCINES

INFECTIOUS DISEASE AND HOST RESPONSE

INNATE IMMUNITY AND INFLAMMATION

MOLECULAR AND STRUCTURAL IMMUNOLOGY

SYSTEMS IMMUNOLOGY

TUMOR IMMUNOLOGY

NOVEL IMMUNOLOGICAL METHODS

LETTERS OF RETRACTION

CORRECTIONS

This Issue

Jump to

Navigate

For Authors

General Information

Journal Services