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Table of Contents

December 15, 2016; Volume 197,Issue 12

IN THIS ISSUE

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    In This Issue

    A Grave Warning from a Mouse Model of Spontaneous Autoimmunity See article p. 4560

    Scavenging Surfactant To Support TB See article p. 4727

    PTPN22 Polices Kinase Phosphorylation in PMNs See article p. 4771

    Mediating Complement Activation Free from mAb Fc See article p. 4829

    J Immunol December 15, 2016, 197 (12) 4507-4508; DOI: https://doi.org/10.4049/jimmunol.1690020

BRIEF REVIEWS

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    Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System
    Charles F. Spurlock, Philip S. Crooke and Thomas M. Aune
    J Immunol December 15, 2016, 197 (12) 4509-4517; DOI: https://doi.org/10.4049/jimmunol.1600970
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    The Impact of Established Immunoregulatory Networks on Vaccine Efficacy and the Development of Immunity to Malaria
    Marcela Montes de Oca, Michael F. Good, James S. McCarthy and Christian R. Engwerda
    J Immunol December 15, 2016, 197 (12) 4518-4526; DOI: https://doi.org/10.4049/jimmunol.1600619

CUTTING EDGE

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    Cutting Edge: BAFF Overexpression Reduces Atherosclerosis via TACI-Dependent B Cell Activation
    Shaun W. Jackson, Nicole E. Scharping, Holly M. Jacobs, Shari Wang, Alan Chait and David J. Rawlings
    J Immunol December 15, 2016, 197 (12) 4529-4534; DOI: https://doi.org/10.4049/jimmunol.1601198
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    Cutting Edge: T Regulatory Cell Depletion Reactivates Latent Simian Immunodeficiency Virus (SIV) in Controller Macaques While Boosting SIV-Specific T Lymphocytes
    Tianyu He, Egidio Brocca-Cofano, Benjamin B. Policicchio, Ranjit Sivanandham, Rajeev Gautam, Kevin D. Raehtz, Cuiling Xu, Ivona Pandrea and Cristian Apetrei
    J Immunol December 15, 2016, 197 (12) 4535-4539; DOI: https://doi.org/10.4049/jimmunol.1601539

ALLERGY AND OTHER HYPERSENSITIVITIES

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    STAT6 Regulates the Development of Eosinophilic versus Neutrophilic Asthma in Response to Alternaria alternata
    Andrea C. Valladao, Charles W. Frevert, Lisa K. Koch, Daniel J. Campbell and Steven F. Ziegler
    J Immunol December 15, 2016, 197 (12) 4541-4551; DOI: https://doi.org/10.4049/jimmunol.1600007

AUTOIMMUNITY

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    IgA Complexes in Plasma and Synovial Fluid of Patients with Rheumatoid Arthritis Induce Neutrophil Extracellular Traps via FcαRI
    Esil Aleyd, Marjon Al, Cornelis W. Tuk, Conny J. van der Laken and Marjolein van Egmond
    J Immunol December 15, 2016, 197 (12) 4552-4559; DOI: https://doi.org/10.4049/jimmunol.1502353
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    Critical Differences between Induced and Spontaneous Mouse Models of Graves’ Disease with Implications for Antigen-Specific Immunotherapy in Humans
    Basil Rapoport, Bianca Banuelos, Holly A. Aliesky, Nicole Hartwig Trier and Sandra M. McLachlan
    J Immunol December 15, 2016, 197 (12) 4560-4568; DOI: https://doi.org/10.4049/jimmunol.1601393
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    Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide
    Jeoung-Eun Park, Jeffrey A. Rotondo, David L. Cullins, David D. Brand, Ae-Kyung Yi, John M. Stuart, Andrew H. Kang and Linda K. Myers
    J Immunol December 15, 2016, 197 (12) 4569-4575; DOI: https://doi.org/10.4049/jimmunol.1600771
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    Age-Associated B Cells with Proinflammatory Characteristics Are Expanded in a Proportion of Multiple Sclerosis Patients
    Nele Claes, Judith Fraussen, Marjan Vanheusden, Niels Hellings, Piet Stinissen, Bart Van Wijmeersch, Raymond Hupperts and Veerle Somers
    J Immunol December 15, 2016, 197 (12) 4576-4583; DOI: https://doi.org/10.4049/jimmunol.1502448

CLINICAL AND HUMAN IMMUNOLOGY

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    CD8αβ+ γδ T Cells: A Novel T Cell Subset with a Potential Role in Inflammatory Bowel Disease
    Mohammad Kadivar, Julia Petersson, Lena Svensson and Jan Marsal
    J Immunol December 15, 2016, 197 (12) 4584-4592; DOI: https://doi.org/10.4049/jimmunol.1601146
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    First-in-Human Study in Healthy Subjects with FR104, a Pegylated Monoclonal Antibody Fragment Antagonist of CD28
    Nicolas Poirier, Gilles Blancho, Maryvonne Hiance, Caroline Mary, Tim Van Assche, Jos Lempoels, Steven Ramael, Weirong Wang, Virginie Thepenier, Cecile Braudeau, Nina Salabert, Regis Josien, Ian Anderson, Ian Gourley, Jean-Paul Soulillou, Didier Coquoz and Bernard Vanhove
    J Immunol December 15, 2016, 197 (12) 4593-4602; DOI: https://doi.org/10.4049/jimmunol.1601538
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    Diversity of Antiviral IgG Effector Activities Observed in HIV-Infected and Vaccinated Subjects
    Yunda Huang, Guido Ferrari, Galit Alter, Donald N. Forthal, John C. Kappes, George K. Lewis, J. Christopher Love, Bhavesh Borate, Linda Harris, Kelli Greene, Hongmei Gao, Tran B. Phan, Gary Landucci, Brittany A. Goods, Karen G. Dowell, Hao D. Cheng, Chris Bailey-Kellogg, David C. Montefiori and Margaret E. Ackerman
    J Immunol December 15, 2016, 197 (12) 4603-4612; DOI: https://doi.org/10.4049/jimmunol.1601197

IMMUNE REGULATION

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    The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
    Xinsheng Ju, Pablo A. Silveira, Wei-Hsun Hsu, Zehra Elgundi, Renz Alingcastre, Nirupama D. Verma, Phillip D. Fromm, Jennifer L. Hsu, Christian Bryant, Ziduo Li, Fiona Kupresanin, Tsun-Ho Lo, Candice Clarke, Kenneth Lee, Helen McGuire, Barbara Fazekas de St. Groth, Stephen R. Larsen, John Gibson, Kenneth F. Bradstock, Georgina J. Clark and Derek N. J. Hart
    J Immunol December 15, 2016, 197 (12) 4613-4625; DOI: https://doi.org/10.4049/jimmunol.1600339
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    Overexpression of Soluble Fas Ligand following Adeno-Associated Virus Gene Therapy Prevents Retinal Ganglion Cell Death in Chronic and Acute Murine Models of Glaucoma
    Anitha Krishnan, Fei Fei, Alexander Jones, Patricia Busto, Ann Marshak-Rothstein, Bruce R. Ksander and Meredith Gregory-Ksander
    J Immunol December 15, 2016, 197 (12) 4626-4638; DOI: https://doi.org/10.4049/jimmunol.1601488
  • Open Access
    The Nuclear Receptor AhR Controls Bone Homeostasis by Regulating Osteoclast Differentiation via the RANK/c-Fos Signaling Axis

    Author Choice Article

    Takashi Izawa, Rieko Arakaki, Hiroki Mori, Takaaki Tsunematsu, Yasusei Kudo, Eiji Tanaka and Naozumi Ishimaru
    J Immunol December 15, 2016, 197 (12) 4639-4650; DOI: https://doi.org/10.4049/jimmunol.1600822
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    Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses
    Noah Alberts-Grill, Daniel Engelbertsen, Dexiu Bu, Amanda Foks, Nir Grabie, Jan M. Herter, Felicia Kuperwaser, Tao Chen, Gina Destefano, Petr Jarolim and Andrew H. Lichtman
    J Immunol December 15, 2016, 197 (12) 4651-4662; DOI: https://doi.org/10.4049/jimmunol.1600206

IMMUNOTHERAPY AND VACCINES

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    HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism
    Todd Bradley, Guang Yang, Olga Ilkayeva, T. Matt Holl, Ruijun Zhang, Jinsong Zhang, Sampa Santra, Christopher B. Fox, Steve G. Reed, Robert Parks, Cindy M. Bowman, Hilary Bouton-Verville, Laura L. Sutherland, Richard M. Scearce, Nathan Vandergrift, Thomas B. Kepler, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Roger McLendon, Jeffrey I. Everitt, Christopher B. Newgard, Laurent Verkoczy, Garnett Kelsoe and Barton F. Haynes
    J Immunol December 15, 2016, 197 (12) 4663-4673; DOI: https://doi.org/10.4049/jimmunol.1601484
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    Mechanisms of Acute Toxicity in NKG2D Chimeric Antigen Receptor T Cell–Treated Mice
    Marie-Louise Sentman, Joana M. Murad, W. James Cook, Ming-Ru Wu, Jake Reder, Susanne H. Baumeister, Glenn Dranoff, Michael W. Fanger and Charles L. Sentman
    J Immunol December 15, 2016, 197 (12) 4674-4685; DOI: https://doi.org/10.4049/jimmunol.1600769

INFECTIOUS DISEASE AND HOST RESPONSE

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    Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection
    Iskra Tuero, David Venzon and Marjorie Robert-Guroff
    J Immunol December 15, 2016, 197 (12) 4686-4695; DOI: https://doi.org/10.4049/jimmunol.1600579
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    Identification of an Activating Chicken Ig-like Receptor Recognizing Avian Influenza Viruses
    Christine A. Jansen, Daphne A. van Haarlem, Beatrice Sperling, Peter J. van Kooten, Erik de Vries, Birgit C. Viertlboeck, Lonneke Vervelde and Thomas W. Göbel
    J Immunol December 15, 2016, 197 (12) 4696-4703; DOI: https://doi.org/10.4049/jimmunol.1600401
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    Duck Tembusu Virus Nonstructural Protein 1 Antagonizes IFN-β Signaling Pathways by Targeting VISA
    Junyong Wang, Cao-Qi Lei, Yanhong Ji, Hongbo Zhou, Yujie Ren, Qianqian Peng, Yan Zeng, Yane Jia, Jinying Ge, Bo Zhong, Yu Li, Jianzhong Wei, Hong-Bing Shu and Qiyun Zhu
    J Immunol December 15, 2016, 197 (12) 4704-4713; DOI: https://doi.org/10.4049/jimmunol.1502317
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    Type I IFN Inhibits Alternative Macrophage Activation during Mycobacterium tuberculosis Infection and Leads to Enhanced Protection in the Absence of IFN-γ Signaling

    Author Choice Article

    Lúcia Moreira-Teixeira, Jeremy Sousa, Finlay W. McNab, Egídio Torrado, Filipa Cardoso, Henrique Machado, Flávia Castro, Vânia Cardoso, Joana Gaifem, Xuemei Wu, Rui Appelberg, António Gil Castro, Anne O’Garra and Margarida Saraiva
    J Immunol December 15, 2016, 197 (12) 4714-4726; DOI: https://doi.org/10.4049/jimmunol.1600584
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    CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
    Claire E. Dodd, Charlie J. Pyle, Rebecca Glowinski, Murugesan V. S. Rajaram and Larry S. Schlesinger
    J Immunol December 15, 2016, 197 (12) 4727-4735; DOI: https://doi.org/10.4049/jimmunol.1600856

INNATE IMMUNITY AND INFLAMMATION

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    Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7
    Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu and Wuhan Xiao
    J Immunol December 15, 2016, 197 (12) 4736-4749; DOI: https://doi.org/10.4049/jimmunol.1601187
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    Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
    Xingyu Wang, Wanming Zhao, Richard M. Ransohoff and Lan Zhou
    J Immunol December 15, 2016, 197 (12) 4750-4761; DOI: https://doi.org/10.4049/jimmunol.1601308
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    Obeticholic Acid Protects against Lipopolysaccharide-Induced Fetal Death and Intrauterine Growth Restriction through Its Anti-Inflammatory Activity
    Yuan-Hua Chen, Xiao-Guang Hu, Yan Zhou, Zhen Yu, Lin Fu, Gui-Bin Zhang, Qing-Li Bo, Hua Wang, Cheng Zhang and De-Xiang Xu
    J Immunol December 15, 2016, 197 (12) 4762-4770; DOI: https://doi.org/10.4049/jimmunol.1601331
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    PTPN22 Is a Critical Regulator of Fcγ Receptor–Mediated Neutrophil Activation

    Author Choice Article

    Sonja Vermeren, Katherine Miles, Julia Y. Chu, Donald Salter, Rose Zamoyska and Mohini Gray
    J Immunol December 15, 2016, 197 (12) 4771-4779; DOI: https://doi.org/10.4049/jimmunol.1600604
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    Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish
    Emily E. Rosowski, Qing Deng, Nancy P. Keller and Anna Huttenlocher
    J Immunol December 15, 2016, 197 (12) 4780-4790; DOI: https://doi.org/10.4049/jimmunol.1600928
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    Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences
    Gael Auray, Irene Keller, Sylvie Python, Markus Gerber, Remy Bruggmann, Nicolas Ruggli and Artur Summerfield
    J Immunol December 15, 2016, 197 (12) 4791-4806; DOI: https://doi.org/10.4049/jimmunol.1600672

MOLECULAR AND STRUCTURAL IMMUNOLOGY

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    Low Constitutive Cell Surface Expression of HLA-B Is Caused by a Posttranslational Mechanism Involving Glu180 and Arg239
    Christoffer Dellgren, Vanessa A. C. Ekwelum, Maria Ormhøj, Nicole Pallesen, Julie Knudsen, Jan O. Nehlin and Torben Barington
    J Immunol December 15, 2016, 197 (12) 4807-4816; DOI: https://doi.org/10.4049/jimmunol.1502546

SYSTEMS IMMUNOLOGY

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    Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection
    Hannah P. Gideon, Jason A. Skinner, Nicole Baldwin, JoAnne L. Flynn and Philana Ling Lin
    J Immunol December 15, 2016, 197 (12) 4817-4828; DOI: https://doi.org/10.4049/jimmunol.1601138

TUMOR IMMUNOLOGY

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    Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells
    Patrick J. Engelberts, Marleen Voorhorst, Janine Schuurman, Tom van Meerten, Joost M. Bakker, Tom Vink, Wendy J. M. Mackus, Esther C. W. Breij, Stefanie Derer, Thomas Valerius, Jan G. J. van de Winkel, Paul W. H. I. Parren and Frank J. Beurskens
    J Immunol December 15, 2016, 197 (12) 4829-4837; DOI: https://doi.org/10.4049/jimmunol.1600811

NOVEL IMMUNOLOGICAL METHODS

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    Generation of Immunity against Pathogens via Single-Domain Antibody–Antigen Constructs
    Joao N. Duarte, Juan J. Cragnolini, Lee Kim Swee, Angelina M. Bilate, Justin Bader, Jessica R. Ingram, Ali Rashidfarrokhi, Tao Fang, Ariën Schiepers, Leo Hanke and Hidde L. Ploegh
    J Immunol December 15, 2016, 197 (12) 4838-4847; DOI: https://doi.org/10.4049/jimmunol.1600692
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    Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells
    Maude Boisvert, Wanrui Zhang, Elizabeth J. Elrod, Nicole F. Bernard, Jean-Pierre Villeneuve, Julie Bruneau, Joseph Marcotrigiano, Naglaa H. Shoukry and Arash Grakoui
    J Immunol December 15, 2016, 197 (12) 4848-4858; DOI: https://doi.org/10.4049/jimmunol.1600763

LETTERS OF RETRACTION

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    Retraction: Regulation of Tumor Cell Sensitivity to TRAIL-Induced Apoptosis by the Metastatic Suppressor Raf Kinase Inhibitor Protein via Yin Yang 1 Inhibition and Death Receptor 5 Up-Regulation
    J Immunol December 15, 2016, 197 (12) 4859; DOI: https://doi.org/10.4049/jimmunol.1601800
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    Retraction: Inhibition of Yin Yang 1-Dependent Repressor Activity of DR5 Transcription and Expression by the Novel Proteasome Inhibitor NPI-0052 Contributes to its TRAIL-Enhanced Apoptosis in Cancer Cells
    J Immunol December 15, 2016, 197 (12) 4860; DOI: https://doi.org/10.4049/jimmunol.1601801

CORRECTIONS

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    Correction: In This Issue
    J Immunol December 15, 2016, 197 (12) 4861; DOI: https://doi.org/10.4049/jimmunol.1601794
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The Journal of Immunology: 197 (12)
The Journal of Immunology
Vol. 197, Issue 12
15 Dec 2016
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  • IN THIS ISSUE
  • BRIEF REVIEWS
  • CUTTING EDGE
  • ALLERGY AND OTHER HYPERSENSITIVITIES
  • AUTOIMMUNITY
  • CLINICAL AND HUMAN IMMUNOLOGY
  • IMMUNE REGULATION
  • IMMUNOTHERAPY AND VACCINES
  • INFECTIOUS DISEASE AND HOST RESPONSE
  • INNATE IMMUNITY AND INFLAMMATION
  • MOLECULAR AND STRUCTURAL IMMUNOLOGY
  • SYSTEMS IMMUNOLOGY
  • TUMOR IMMUNOLOGY
  • NOVEL IMMUNOLOGICAL METHODS
  • LETTERS OF RETRACTION
  • CORRECTIONS

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Neutrophil Cathepsin G Regulates Dendritic Cell Production of IL-12 during Development of CD4 T Cell Responses to Antigens in the Skin
Histone H3K27 Demethylase Negatively Controls the Memory Formation of Antigen-Stimulated CD8+ T Cells
Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells
A Prime-Pull-Amplify Vaccination Strategy To Maximize Induction of Circulating and Genital-Resident Intraepithelial CD8+ Memory T Cells
What’s Bred in the Bone: Calcium Channels in Lymphocytes

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