Src homology region 2 domain-containing phosphatase-2 (SHP-2) is ubiquitously expressed and is required for gastrulation, hematopoiesis, and embryonic development. Constitutive deletion of SHP-2 in mice is embryonically lethal. During development and maturation, certain subsets of T cells express a variety of inhibitory receptors known to associate with SHP-2. These subsets include iNKT cells, Ly49+CD8+ T cells with a memory phenotype, and exhausted T cells during chronic infection. We hypothesized that conditional SHP-2 deletion would have major effects on T cell development by altering the thresholds for positive and negative selection. Surprisingly, and in contrast to a previous report, we found that SHP-2-deficient CD8+ T cells and iNKT cells develop normally in the thymus and exhibit proper maturation in the periphery. Therefore, SHP-2 is dispensable for development and differentiation of both effector CD8+ T cells and iNKT cells.
- Copyright © 2013 by The American Association of Immunologists, Inc.