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HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable

Stephen C. De Rosa, Evan P. Thomas, John Bui, Yunda Huang, Allan deCamp, Cecilia Morgan, Spyros A. Kalams, Georgia D. Tomaras, Rama Akondy, Rafi Ahmed, Chuen-Yen Lau, Barney S. Graham, Gary J. Nabel, M. Juliana McElrath and the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
J Immunol September 15, 2011, 187 (6) 3391-3401; DOI: https://doi.org/10.4049/jimmunol.1101421
Stephen C. De Rosa
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195;Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;HIV Vaccine Trials Network, Seattle, WA 98109;
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Evan P. Thomas
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;HIV Vaccine Trials Network, Seattle, WA 98109;
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John Bui
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
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Yunda Huang
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;HIV Vaccine Trials Network, Seattle, WA 98109;
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Allan deCamp
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
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Cecilia Morgan
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;HIV Vaccine Trials Network, Seattle, WA 98109;
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Spyros A. Kalams
Department of Medicine, Vanderbilt University, Nashville, TN 37232;
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Georgia D. Tomaras
Human Vaccine Institute, Duke University, Durham, NC 27710;
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Rama Akondy
Emory Vaccine Institute, Emory University, Atlanta, GA 30329;
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Rafi Ahmed
Emory Vaccine Institute, Emory University, Atlanta, GA 30329;
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Chuen-Yen Lau
Division of AIDS, National Institutes of Health, Bethesda, MD 20892;
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Barney S. Graham
Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892; and
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Gary J. Nabel
Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892; and
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M. Juliana McElrath
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195;Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;HIV Vaccine Trials Network, Seattle, WA 98109;Department of Medicine, University of Washington, Seattle, WA 98195
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Article Information

vol. 187 no. 6 3391-3401
DOI 
https://doi.org/10.4049/jimmunol.1101421
PubMed 
21844392

Published By 
The American Association of Immunologists, Inc.
Print ISSN 
0022-1767
Online ISSN 
1550-6606
History 
  • Received May 16, 2011
  • Accepted July 11, 2011
  • Published online September 6, 2011.

Article Versions

  • Older version (August 15, 2011 - 11:34).
  • You are viewing the most recent version of this article.

Author Information

  1. Stephen C. De Rosa*,†,‡,
  2. Evan P. Thomas†,‡,
  3. John Bui†,
  4. Yunda Huang†,‡,
  5. Allan deCamp†,
  6. Cecilia Morgan†,‡,
  7. Spyros A. Kalams§,
  8. Georgia D. Tomaras¶,
  9. Rama Akondy‖,
  10. Rafi Ahmed‖,
  11. Chuen-Yen Lau#,
  12. Barney S. Graham**,
  13. Gary J. Nabel**,
  14. M. Juliana McElrath*,†,‡,††,
  15. the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
  1. *Department of Laboratory Medicine, University of Washington, Seattle, WA 98195;
  2. †Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
  3. ‡HIV Vaccine Trials Network, Seattle, WA 98109;
  4. §Department of Medicine, Vanderbilt University, Nashville, TN 37232;
  5. ¶Human Vaccine Institute, Duke University, Durham, NC 27710;
  6. ‖Emory Vaccine Institute, Emory University, Atlanta, GA 30329;
  7. #Division of AIDS, National Institutes of Health, Bethesda, MD 20892;
  8. **Vaccine Research Center, National Institutes of Health, Bethesda, MD 20892; and
  9. ††Department of Medicine, University of Washington, Seattle, WA 98195
  1. Address correspondence and reprint requests to Dr. Stephen C. De Rosa, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, LE-200, Seattle WA 98109. E-mail address: sderosa{at}fhcrc.org
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Aug 2011536781
Sep 201199958118
Oct 20112514851
Nov 20111552928
Dec 20111083430
Total 20112049176308
Jan 2012882321
Feb 20121082728
Mar 2012892022
Apr 2012872015
May 2012481817
Jun 2012481514
Jul 2012372910
Aug 2012612920
Sep 2012631114
Oct 2012681723
Nov 2012663536
Dec 2012261510
Total 2012789259230
Jan 2013351921
Feb 2013441515
Mar 2013712415
Apr 2013811618
May 2013471311
Jun 2013311316
Jul 20131966
Aug 20132845
Sep 201320810
Oct 201339116
Nov 201334219
Dec 201328166
Total 2013477166138
Jan 201435105
Feb 20143336
Mar 2014161211
Apr 201427137
May 201425209
Jun 2014221713
Jul 2014331611
Aug 2014181128
Sep 201421618
Oct 201419911
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Dec 201421613
Total 2014297228121
Jan 2015241119
Feb 201538713
Mar 201542615
Apr 2015151123
May 2015121512
Jun 201581315
Jul 2015181214
Aug 20151057
Sep 2015131611
Oct 201538913
Nov 201515617
Dec 201538511
Total 2015271116170
Jan 201616916
Feb 20161346
Mar 201619811
Apr 20161033
May 20162649
Jun 201615249
Jul 2016134613
Aug 201613405
Sep 201614412
Oct 2016107214
Nov 201614267
Dec 201610316
Total 2016173308101
Jan 20178612
Feb 201706525
Mar 201733023
Apr 201723070
May 201723549
Jun 201702613
Jul 20170128
Aug 20173311
Sep 2017069
Oct 2017081
Nov 20170106
Dec 2017197
Total 201719295224
Jan 20183636
Feb 2018065
Mar 20182711
Apr 2018295
May 20184103
Jun 20180174
Jul 2018145
Aug 2018041
Sep 2018197
Oct 201831112
Nov 20183129
Dec 2018087
Total 20181916075
Jan 20193158
Total 20193158
Total409717231375

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The Journal of Immunology: 187 (6)
The Journal of Immunology
Vol. 187, Issue 6
15 Sep 2011
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HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable
Stephen C. De Rosa, Evan P. Thomas, John Bui, Yunda Huang, Allan deCamp, Cecilia Morgan, Spyros A. Kalams, Georgia D. Tomaras, Rama Akondy, Rafi Ahmed, Chuen-Yen Lau, Barney S. Graham, Gary J. Nabel, M. Juliana McElrath, the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
The Journal of Immunology September 15, 2011, 187 (6) 3391-3401; DOI: 10.4049/jimmunol.1101421

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HIV-DNA Priming Alters T Cell Responses to HIV-Adenovirus Vaccine Even When Responses to DNA Are Undetectable
Stephen C. De Rosa, Evan P. Thomas, John Bui, Yunda Huang, Allan deCamp, Cecilia Morgan, Spyros A. Kalams, Georgia D. Tomaras, Rama Akondy, Rafi Ahmed, Chuen-Yen Lau, Barney S. Graham, Gary J. Nabel, M. Juliana McElrath, the National Institute of Allergy and Infectious Diseases HIV Vaccine Trials Network
The Journal of Immunology September 15, 2011, 187 (6) 3391-3401; DOI: 10.4049/jimmunol.1101421
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Print ISSN 0022-1767        Online ISSN 1550-6606