On the cover: Mice that express the DO11 TCR transgene and produce ovalbumin in the pancreas (DO11 × RIP-mOVA) develop spontaneous diabetes. Sections of frozen pancreas from an 18-wk-old transgenic animal were stained by immunohistology for DO11 T cells (brown) and B220-positive B cells (blue). Clough, L. E., C. J. Wang, E. M. Schmidt, G. Booth, T. Z. Hou, G. A. Ryan, and L. S. K. Walker. 2008. Release from regulatory T cell-mediated suppression during the onset of tissue-specific autoimmunity is associated with elevated IL-21. J. Immunol. 180: 5393–5401.