Table of Contents

CELLULAR IMMUNOLOGY AND IMMUNE REGULATION

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  Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection

  Carsten Wiethe, Andrea Debus, Markus Mohrs, Alexander Steinkasserer, Manfred Lutz and André Gessner

  J Immunol April 1, 2008, 180 (7) 4371-4381; DOI: https://doi.org/10.4049/jimmunol.180.7.4371
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  CD40 on APCs Is Needed for Optimal Programming, Maintenance, and Recall of CD8⁺ T Cell Memory Even in the Absence of CD4⁺ T Cell Help

  Maria Genevive H. Hernandez, Lianjun Shen and Kenneth L. Rock

  J Immunol April 1, 2008, 180 (7) 4382-4390; DOI: https://doi.org/10.4049/jimmunol.180.7.4382
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  IL-15 Transpresentation Augments CD8⁺ T Cell Activation and Is Required for Optimal Recall Responses by Central Memory CD8⁺ T Cells

  Andy I. Kokaji, Deanna L. Hockley and Kevin P. Kane

  J Immunol April 1, 2008, 180 (7) 4391-4401; DOI: https://doi.org/10.4049/jimmunol.180.7.4391
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  AML1/Runx1 Negatively Regulates Quiescent Hematopoietic Stem Cells in Adult Hematopoiesis

  Motoshi Ichikawa, Susumu Goyama, Takashi Asai, Masahito Kawazu, Masahiro Nakagawa, Masataka Takeshita, Shigeru Chiba, Seishi Ogawa and Mineo Kurokawa

  J Immunol April 1, 2008, 180 (7) 4402-4408; DOI: https://doi.org/10.4049/jimmunol.180.7.4402
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  Lack of TIM-3 Immunoregulation in Multiple Sclerosis

  Li Yang, David E. Anderson, Juhi Kuchroo and David A. Hafler

  J Immunol April 1, 2008, 180 (7) 4409-4414; DOI: https://doi.org/10.4049/jimmunol.180.7.4409
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  Innate-Like Effector Differentiation of Human Invariant NKT Cells Driven by IL-7

  Claudia de Lalla, Nicola Festuccia, Inka Albrecht, Hyun-Dong Chang, Grazia Andolfi, Ulrike Benninghoff, Ferdinando Bombelli, Giovanna Borsellino, Alessandro Aiuti, Andreas Radbruch, Paolo Dellabona and Giulia Casorati

  J Immunol April 1, 2008, 180 (7) 4415-4424; DOI: https://doi.org/10.4049/jimmunol.180.7.4415
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  Inhibition of TLR Activation and Up-Regulation of IL-1R-Associated Kinase-M Expression by Exogenous Gangliosides

  Weiping Shen, Kelly Stone, Alessandra Jales, David Leitenberg and Stephan Ladisch

  J Immunol April 1, 2008, 180 (7) 4425-4432; DOI: https://doi.org/10.4049/jimmunol.180.7.4425
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  CD4⁺CD25⁺ Regulatory T Cells Specific for a Thymus-Expressed Antigen Prevent the Development of Anaphylaxis to Self

  Stefano Scabeni, Marilena Lapilla, Silvia Musio, Barbara Gallo, Emilio Ciusani, Lawrence Steinman, Renato Mantegazza and Rosetta Pedotti

  J Immunol April 1, 2008, 180 (7) 4433-4440; DOI: https://doi.org/10.4049/jimmunol.180.7.4433
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  Gastrointestinal Dendritic Cells Promote Th2 Skewing via OX40L

  Ana Belén Blázquez and M. Cecilia Berin

  J Immunol April 1, 2008, 180 (7) 4441-4450; DOI: https://doi.org/10.4049/jimmunol.180.7.4441
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  Loss of IFN-γ Enables the Expansion of Autoreactive CD4⁺ T Cells to Induce Experimental Autoimmune Encephalomyelitis by a Nonencephalitogenic Myelin Variant Antigen

  Joseph J. Sabatino, John Shires, John D. Altman, Mandy L. Ford and Brian D. Evavold

  J Immunol April 1, 2008, 180 (7) 4451-4457; DOI: https://doi.org/10.4049/jimmunol.180.7.4451
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  Autoimmunity to Both Proinsulin and IGRP Is Required for Diabetes in Nonobese Diabetic 8.3 TCR Transgenic Mice

  Balasubramanian Krishnamurthy, Lina Mariana, Shane A. Gellert, Peter G. Colman, Leonard C. Harrison, Andrew M. Lew, Pere Santamaria, Helen E. Thomas and Thomas W. H. Kay

  J Immunol April 1, 2008, 180 (7) 4458-4464; DOI: https://doi.org/10.4049/jimmunol.180.7.4458
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  Impact of Post-Thymic Cellular Longevity on the Development of Age-Associated CD4⁺ T Cell Defects

  Stephen C. Jones, Karen Clise-Dwyer, Gail Huston, John Dibble, Sheri Eaton, Laura Haynes and Susan L. Swain

  J Immunol April 1, 2008, 180 (7) 4465-4475; DOI: https://doi.org/10.4049/jimmunol.180.7.4465
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  Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

  Sarah R. Jacobs, Catherine E. Herman, Nancie J. MacIver, Jessica A. Wofford, Heather L. Wieman, Jeremy J. Hammen and Jeffrey C. Rathmell

  J Immunol April 1, 2008, 180 (7) 4476-4486; DOI: https://doi.org/10.4049/jimmunol.180.7.4476
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  De Novo Production of K-α1 Tubulin-Specific Antibodies: Role in Chronic Lung Allograft Rejection

  Trudie A. Goers, Sabarinathan Ramachandran, Aviva Aloush, Elbert Trulock, G. Alexander Patterson and Thalachallour Mohanakumar

  J Immunol April 1, 2008, 180 (7) 4487-4494; DOI: https://doi.org/10.4049/jimmunol.180.7.4487
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  In Vivo Regulation of Experimental Autoimmune Encephalomyelitis by NK Cells: Alteration of Primary Adaptive Responses

  Robin Winkler-Pickett, Howard A. Young, James M. Cherry, John Diehl, John Wine, Timothy Back, William E. Bere, Anna T. Mason and John R. Ortaldo

  J Immunol April 1, 2008, 180 (7) 4495-4506; DOI: https://doi.org/10.4049/jimmunol.180.7.4495
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  Brief Antigenic Stimulation Generates Effector CD8 T Cells with Low Cytotoxic Activity and High IL-2 Production

  David Usharauli and Tirumalai Kamala

  J Immunol April 1, 2008, 180 (7) 4507-4513; DOI: https://doi.org/10.4049/jimmunol.180.7.4507
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  Assessment of Bet v 1-Specific CD4⁺ T Cell Responses in Allergic and Nonallergic Individuals Using MHC Class II Peptide Tetramers

  Laurence Van Overtvelt, Erik Wambre, Bernard Maillère, Eric von Hofe, Anne Louise, Anne Marie Balazuc, Barbara Bohle, Didier Ebo, Christophe Leboulaire, Gilles Garcia and Philippe Moingeon

  J Immunol April 1, 2008, 180 (7) 4514-4522; DOI: https://doi.org/10.4049/jimmunol.180.7.4514
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  Selective Roles of MAPKs during the Macrophage Response to IFN-γ

  Annabel F. Valledor, Ester Sánchez-Tilló, Luis Arpa, Jin Mo Park, Carme Caelles, Jorge Lloberas and Antonio Celada

  J Immunol April 1, 2008, 180 (7) 4523-4529; DOI: https://doi.org/10.4049/jimmunol.180.7.4523
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  Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis

  Kazuyuki Tsukamoto, Mareki Ohtsuji, Wakana Shiroiwa, Qingshun Lin, Kazuhiro Nakamura, Hiromichi Tsurui, Yi Jiang, Katsuko Sudo, Hiroyuki Nishimura, Toshikazu Shirai and Sachiko Hirose

  J Immunol April 1, 2008, 180 (7) 4530-4539; DOI: https://doi.org/10.4049/jimmunol.180.7.4530
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  Inducing Antitumor T Cell Immunity: Comparative Functional Analysis of Interstitial Versus Langerhans Dendritic Cells in a Human Cell Line Model

  Saskia J. A. M. Santegoets, Hetty J. Bontkes, Anita G. M. Stam, Farien Bhoelan, Janneke J. Ruizendaal, Alfons J. M. van den Eertwegh, Erik Hooijberg, Rik J. Scheper and Tanja D. de Gruijl

  J Immunol April 1, 2008, 180 (7) 4540-4549; DOI: https://doi.org/10.4049/jimmunol.180.7.4540
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  Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8⁺ T Cells

  Amber van Stijn, Ajda T. Rowshani, Sila L. Yong, Frank Baas, Eddy Roosnek, Ineke J. M. ten Berge and René A. W. van Lier

  J Immunol April 1, 2008, 180 (7) 4550-4560; DOI: https://doi.org/10.4049/jimmunol.180.7.4550
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  Dendritic Cell-Dependent Inhibition of B Cell Proliferation Requires CD22

  Lorna Santos, Kevin E. Draves, Mark Boton, Prabhjit K. Grewal, Jamey D. Marth and Edward A. Clark

  J Immunol April 1, 2008, 180 (7) 4561-4569; DOI: https://doi.org/10.4049/jimmunol.180.7.4561
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  TRAIL Deficiency Does Not Rescue Impaired CD8⁺ T Cell Memory Generated in the Absence of CD4⁺ T Cell Help

  Jilian A. Sacks and Michael J. Bevan

  J Immunol April 1, 2008, 180 (7) 4570-4576; DOI: https://doi.org/10.4049/jimmunol.180.7.4570
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  Immunodominance in the TCR Repertoire of αTCR Peptide-Specific CD4⁺ Treg Population That Controls Experimental Autoimmune Encephalomyelitis

  Loui Thomas Madakamutil, Igor Maricic, Eli E. Sercarz and Vipin Kumar

  J Immunol April 1, 2008, 180 (7) 4577-4585; DOI: https://doi.org/10.4049/jimmunol.180.7.4577
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  Activation and Function of the mTORC1 Pathway in Mast Cells

  Mi-Sun Kim, Hye Sun Kuehn, Dean D. Metcalfe and Alasdair M. Gilfillan

  J Immunol April 1, 2008, 180 (7) 4586-4595; DOI: https://doi.org/10.4049/jimmunol.180.7.4586
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  Induction of Antitumor Immune Response by Homeostatic Proliferation and CD28 Signaling

  Toshihiro Suzuki, Shuhei Ogawa, Kazunari Tanabe, Hideaki Tahara, Ryo Abe and Hidehiro Kishimoto

  J Immunol April 1, 2008, 180 (7) 4596-4605; DOI: https://doi.org/10.4049/jimmunol.180.7.4596
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  Intracellular Retention of the NKG2D Ligand MHC Class I Chain-Related Gene A in Human Melanomas Confers Immune Privilege and Prevents NK Cell-Mediated Cytotoxicity

  Mercedes B. Fuertes, María V. Girart, Luciana L. Molinero, Carolina I. Domaica, Lucas E. Rossi, María M. Barrio, José Mordoh, Gabriel A. Rabinovich and Norberto W. Zwirner

  J Immunol April 1, 2008, 180 (7) 4606-4614; DOI: https://doi.org/10.4049/jimmunol.180.7.4606
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  Invariant NKT Cells Promote CD8⁺ Cytotoxic T Cell Responses by Inducing CD70 Expression on Dendritic Cells

  Vadim Y. Taraban, Sonya Martin, Kathrine E. Attfield, Martin J. Glennie, Tim Elliott, Dirk Elewaut, Serge Van Calenbergh, Bruno Linclau and Aymen Al-Shamkhani

  J Immunol April 1, 2008, 180 (7) 4615-4620; DOI: https://doi.org/10.4049/jimmunol.180.7.4615
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  NK Cells Contribute to Intracellular Bacterial Infection-Mediated Inhibition of Allergic Responses

  Xiaobing Han, Yijun Fan, Shuhe Wang, Lei Jiao, Hongyu Qiu and Xi Yang

  J Immunol April 1, 2008, 180 (7) 4621-4628; DOI: https://doi.org/10.4049/jimmunol.180.7.4621
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  Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence

  Peter Velázquez, Bo Wei, Michael McPherson, Lesley Marie A. Mendoza, Sandra L. Nguyen, Olga Turovskaya, Mitchell Kronenberg, Tiffany T. Huang, Matthew Schrage, Lynn N. Lobato, Daisuke Fujiwara, Sarah Brewer, Moshe Arditi, Genhong Cheng, R. Balfour Sartor, Rodney D. Newberry and Jonathan Braun

  J Immunol April 1, 2008, 180 (7) 4629-4638; DOI: https://doi.org/10.4049/jimmunol.180.7.4629
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  Multivectorial Abnormal Cell Migration in the NOD Mouse Thymus

  Daniella A. Mendes-da-Cruz, Salete Smaniotto, Alexandre C. Keller, Mireille Dardenne and Wilson Savino

  J Immunol April 1, 2008, 180 (7) 4639-4647; DOI: https://doi.org/10.4049/jimmunol.180.7.4639
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  Mast Cell Migration from the Skin to the Draining Lymph Nodes upon Ultraviolet Irradiation Represents a Key Step in the Induction of Immune Suppression

  Scott N. Byrne, Alberto Y. Limón-Flores and Stephen E. Ullrich

  J Immunol April 1, 2008, 180 (7) 4648-4655; DOI: https://doi.org/10.4049/jimmunol.180.7.4648
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  Developmental Control of Integrin Expression Regulates Th2 Effector Homing

  Seung-Hyo Lee, Joseph E. Prince, Muhammad Rais, Farrah Kheradmand, Christie M. Ballantyne, Gabriele Weitz-Schmidt, C. Wayne Smith and David B. Corry

  J Immunol April 1, 2008, 180 (7) 4656-4667; DOI: https://doi.org/10.4049/jimmunol.180.7.4656
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  Protein Kinase Cα and ζ Differentially Regulate Death-Inducing Signaling Complex Formation in Cigarette Smoke Extract-Induced Apoptosis

  Jeong-Woong Park, Hong Pyo Kim, Seon-Jin Lee, Xue Wang, Yong Wang, Emeka Ifedigbo, Simon C. Watkins, Motoi Ohba, Stefan W. Ryter, Yatin M. Vyas and Augustine M. K. Choi

  J Immunol April 1, 2008, 180 (7) 4668-4678; DOI: https://doi.org/10.4049/jimmunol.180.7.4668
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  Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4⁺ Self-Reactive T Cells

  Magali Terme, Nathalie Chaput, Behazine Combadiere, Averil Ma, Toshiaki Ohteki and Laurence Zitvogel

  J Immunol April 1, 2008, 180 (7) 4679-4686; DOI: https://doi.org/10.4049/jimmunol.180.7.4679
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  Renal Cell Carcinoma Tumors Induce T Cell Apoptosis through Receptor-Dependent and Receptor-Independent Pathways

  Tanya Das, Gaurisankar Sa, Ewa Paszkiewicz-Kozik, Cynthia Hilston, Luis Molto, Patricia Rayman, Daisuke Kudo, Kaushik Biswas, Ronald M. Bukowski, James H. Finke and Charles S. Tannenbaum

  J Immunol April 1, 2008, 180 (7) 4687-4696; DOI: https://doi.org/10.4049/jimmunol.180.7.4687
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  Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function

  Jonathan Jantsch, Dipshikha Chakravortty, Nadine Turza, Alexander T. Prechtel, Björn Buchholz, Roman G. Gerlach, Melanie Volke, Joachim Gläsner, Christina Warnecke, Michael S. Wiesener, Kai-Uwe Eckardt, Alexander Steinkasserer, Michael Hensel and Carsten Willam

  J Immunol April 1, 2008, 180 (7) 4697-4705; DOI: https://doi.org/10.4049/jimmunol.180.7.4697
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  TIM-4 Expressed on APCs Induces T Cell Expansion and Survival

  Roselynn Rodriguez-Manzanet, Jennifer Hartt Meyers, Savithri Balasubramanian, Jacqueline Slavik, Nasim Kassam, Valerie Dardalhon, Edward A. Greenfield, Ana C. Anderson, Raymond A. Sobel, David A. Hafler, Terry B. Strom and Vijay K. Kuchroo

  J Immunol April 1, 2008, 180 (7) 4706-4713; DOI: https://doi.org/10.4049/jimmunol.180.7.4706
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  Combined CXCR3/CCR5 Blockade Attenuates Acute and Chronic Rejection

  Gabriel T. Schnickel, Sam Bastani, George R. Hsieh, Ali Shefizadeh, Rubina Bhatia, Michael C. Fishbein, John Belperio and Abbas Ardehali

  J Immunol April 1, 2008, 180 (7) 4714-4721; DOI: https://doi.org/10.4049/jimmunol.180.7.4714
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  Langerin Expressing Cells Promote Skin Immune Responses under Defined Conditions

  Liangchun Wang, Laura S. Bursch, Adrien Kissenpfennig, Bernard Malissen, Stephen C. Jameson and Kristin A. Hogquist

  J Immunol April 1, 2008, 180 (7) 4722-4727; DOI: https://doi.org/10.4049/jimmunol.180.7.4722
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  B Cell Receptor Basal Signaling Regulates Antigen-Induced Ig Light Chain Rearrangements

  Brian R. Schram, Lina E. Tze, Laura B. Ramsey, Jiabin Liu, Lydia Najera, Amanda L. Vegoe, Richard R. Hardy, Keli L. Hippen, Michael A. Farrar and Timothy W. Behrens

  J Immunol April 1, 2008, 180 (7) 4728-4741; DOI: https://doi.org/10.4049/jimmunol.180.7.4728
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  Homeostasis and Effector Function of Lymphopenia-Induced “Memory-Like” T Cells in Constitutively T Cell-Depleted Mice

  David Voehringer, Hong-Erh Liang and Richard M. Locksley

  J Immunol April 1, 2008, 180 (7) 4742-4753; DOI: https://doi.org/10.4049/jimmunol.180.7.4742
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  CD4⁺ T Lymphocytes Are Not Necessary for the Acute Rejection of Vascularized Mouse Lung Transplants

  Andrew E. Gelman, Mikio Okazaki, Jiaming Lai, Christopher G. Kornfeld, Friederike H. Kreisel, Steven B. Richardson, Seiichiro Sugimoto, Jeremy R. Tietjens, G. Alexander Patterson, Alexander S. Krupnick and Daniel Kreisel

  J Immunol April 1, 2008, 180 (7) 4754-4762; DOI: https://doi.org/10.4049/jimmunol.180.7.4754
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  TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

  Vicky Lampropoulou, Kai Hoehlig, Toralf Roch, Patricia Neves, Elisabeth Calderón Gómez, Claire H. Sweenie, Yi Hao, Antonio A. Freitas, Ulrich Steinhoff, Stephen M. Anderton and Simon Fillatreau

  J Immunol April 1, 2008, 180 (7) 4763-4773; DOI: https://doi.org/10.4049/jimmunol.180.7.4763