On the cover: Adoptive transfer of OVA-specific T cells (red), capable of expressing IL-4 (green), into IL-4^-/- mice inoculated with N. brasiliensis plus OVA. Frozen draining lymph node sections from day 3 after inoculation were also stained for B cells (blue) to indicate T:B zone, where IL-4 protein is initially expressed. Liu, Q., Z. Liu, C. T. Rozo, H. A. Hamed, F. Alem, J. F. Urban, Jr., and W. C. Gause. 2007. The role of B cells in the development of CD4 effector T cells during a polarized Th2 immune response. J. Immunol. 179: 3821–3830.