Regulation of Hepatic Fibrosis and Extracellular Matrix Genes by the Th Response: New Insight into the Role of Tissue Inhibitors of Matrix Metalloproteinases

^*Schistosomiasis Immunology and Pathology Unit, Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;
^†Biomedical Research Institute, Rockville, MD 20852; and
^‡Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY 14263

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	Abstract	Full	PDF
Dec 2001	83	105	131
Total 2001	83	105	131
Jan 2002	18	165	68
Feb 2002	6	82	47
Mar 2002	9	77	46
Apr 2002	6	57	33
May 2002	6	56	30
Jun 2002	0	39	18
Jul 2002	3	45	36
Aug 2002	4	36	18
Sep 2002	5	57	17
Oct 2002	4	37	25
Nov 2002	8	35	21
Dec 2002	4	29	16
Total 2002	73	715	375
Jan 2003	3	37	35
Feb 2003	3	37	22
Mar 2003	6	43	28
Apr 2003	3	36	32
May 2003	2	40	21
Jun 2003	2	23	12
Jul 2003	2	48	32
Aug 2003	8	28	23
Sep 2003	8	27	15
Oct 2003	13	56	20
Nov 2003	19	36	13
Dec 2003	13	30	17
Total 2003	82	441	270
Jan 2004	15	38	15
Feb 2004	8	39	28
Mar 2004	7	27	11
Apr 2004	13	40	17
May 2004	8	37	18
Jun 2004	8	31	22
Jul 2004	12	59	30
Aug 2004	14	38	25
Sep 2004	11	43	21
Oct 2004	7	29	26
Nov 2004	7	48	35
Dec 2004	7	47	27
Total 2004	117	476	275
Jan 2005	6	46	29
Feb 2005	7	48	16
Mar 2005	13	81	28
Apr 2005	3	38	19
May 2005	7	27	16
Jun 2005	4	41	21
Jul 2005	5	33	35
Aug 2005	5	27	14
Sep 2005	2	20	23
Oct 2005	3	25	14
Nov 2005	4	43	22
Dec 2005	6	20	14
Total 2005	65	449	251
Jan 2006	5	34	18
Feb 2006	2	33	32
Mar 2006	4	37	22
Apr 2006	4	34	24
May 2006	3	18	13
Jun 2006	4	18	9
Jul 2006	3	15	14
Aug 2006	10	16	13
Sep 2006	2	34	19
Oct 2006	7	29	10
Nov 2006	4	38	25
Dec 2006	5	25	21
Total 2006	53	331	220
Jan 2007	6	18	22
Feb 2007	1	35	14
Mar 2007	5	29	18
Apr 2007	3	26	13
May 2007	4	38	21
Jun 2007	10	20	19
Jul 2007	13	26	17
Aug 2007	3	15	13
Sep 2007	5	14	10
Oct 2007	7	16	11
Nov 2007	8	11	18
Dec 2007	6	13	16
Total 2007	71	261	192
Jan 2008	5	15	14
Feb 2008	8	9	14
Mar 2008	29	36	23
Apr 2008	14	14	17
May 2008	23	18	13
Jun 2008	7	16	9
Jul 2008	17	21	23
Aug 2008	42	21	18
Sep 2008	35	28	12
Oct 2008	13	16	11
Nov 2008	13	17	18
Dec 2008	8	7	15
Total 2008	214	218	187
Jan 2009	14	29	22
Feb 2009	11	18	12
Mar 2009	11	9	13
Apr 2009	8	14	13
May 2009	10	19	13
Jun 2009	6	13	2
Jul 2009	11	22	11
Aug 2009	4	16	12
Sep 2009	12	11	12
Oct 2009	19	16	13
Nov 2009	4	11	7
Dec 2009	9	13	13
Total 2009	119	191	143
Jan 2010	8	7	6
Feb 2010	3	12	8
Mar 2010	12	14	14
Apr 2010	9	21	6
May 2010	7	24	16
Jun 2010	8	21	18
Jul 2010	6	22	16
Aug 2010	8	12	14
Sep 2010	4	12	9
Oct 2010	5	13	14
Nov 2010	7	10	5
Dec 2010	6	9	5
Total 2010	83	177	131
Jan 2011	10	8	12
Feb 2011	15	8	8
Mar 2011	7	14	11
Apr 2011	2	15	12
May 2011	4	17	16
Jun 2011	8	16	8
Jul 2011	8	6	13
Aug 2011	9	10	13
Sep 2011	8	15	9
Oct 2011	15	9	15
Nov 2011	16	9	9
Dec 2011	9	14	10
Total 2011	111	141	136
Jan 2012	14	2	13
Feb 2012	10	9	11
Mar 2012	10	10	5
Apr 2012	8	3	6
May 2012	11	9	16
Jun 2012	10	8	24
Jul 2012	12	5	8
Aug 2012	12	11	3
Sep 2012	10	4	7
Oct 2012	6	7	16
Nov 2012	5	12	14
Dec 2012	10	11	10
Total 2012	118	91	133
Jan 2013	9	22	10
Feb 2013	11	13	7
Mar 2013	9	6	4
Apr 2013	22	8	12
May 2013	8	13	8
Jun 2013	8	3	4
Jul 2013	7	6	6
Aug 2013	4	3	1
Sep 2013	7	5	4
Oct 2013	7	10	3
Nov 2013	4	5	5
Dec 2013	4	2	2
Total 2013	100	96	66
Jan 2014	6	3	2
Feb 2014	10	8	5
Mar 2014	6	5	5
Apr 2014	16	7	8
May 2014	10	16	9
Jun 2014	8	12	3
Jul 2014	16	26	5
Aug 2014	11	9	7
Sep 2014	8	8	5
Oct 2014	10	20	18
Nov 2014	12	6	20
Dec 2014	9	11	9
Total 2014	122	131	96
Jan 2015	11	5	6
Feb 2015	6	6	9
Mar 2015	7	10	8
Apr 2015	2	8	10
May 2015	13	6	11
Jun 2015	3	5	6
Jul 2015	9	11	7
Aug 2015	6	14	10
Sep 2015	17	12	8
Oct 2015	5	8	2
Nov 2015	25	17	14
Dec 2015	3	10	5
Total 2015	107	112	96
Jan 2016	10	7	12
Feb 2016	5	8	15
Mar 2016	0	23	17
Apr 2016	3	9	11
May 2016	2	9	15
Jun 2016	2	7	12
Jul 2016	5	6	12
Aug 2016	3	7	16
Sep 2016	6	2	9
Oct 2016	7	5	31
Nov 2016	1	17	27
Dec 2016	3	9	22
Total 2016	47	109	199
Jan 2017	0	11	19
Feb 2017	1	9	6
Mar 2017	4	18	9
Apr 2017	6	23	7
May 2017	2	29	6
Jun 2017	5	24	14
Total 2017	18	114	61
Total	1583	4158	2962