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Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody

Rita B. Effros, Mark E. Frankel, Walter Gerhard and Peter C. Doherty
J Immunol September 1, 1979, 123 (3) 1343-1346;
Rita B. Effros
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Mark E. Frankel
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Walter Gerhard
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Peter C. Doherty
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Abstract

The in vitro activity of influenza-specific cytotoxic T cells can be inhibited by incubation of the target cells with monoclonal anti-influenza antibodies. Hybridoma antibodies that bind to the virus HA inhibit the cytotoxic activity of TDL for the virus-infected target by as much as 80%, whereas these same antibodies never reduce splenic T cell function by more than 40%. This reflects the fact that TDL from anti-influenza strain A/WSN/33 (HON1) are highly subtype-specific, whereas splenic effector cells from the same mice are cross-reactive for target cells infected with heterologous influenza A viruses. These findings are discussed in the light of previous failures to block virus-immune T cell effector function with heterogeneous antisera produced in vivo, and are considered to favor the idea that at least some of the “virus-immune” T cells are indeed recognizing viral antigens.

Footnotes

  • ↵1 This work was supported by research Grants AI 14162, AI 13989, and NS 11036 from the United States Public Health Service and by the National Multiple Sclerosis Society.

  • Received April 16, 1979.
  • Accepted June 19, 1979.
  • Copyright © 1979 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 123, Issue 3
1 Sep 1979
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Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody
Rita B. Effros, Mark E. Frankel, Walter Gerhard, Peter C. Doherty
The Journal of Immunology September 1, 1979, 123 (3) 1343-1346;

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Inhibition of Influenza-Immune T Cell Effector Function by Virus-Specific Hybridoma Antibody
Rita B. Effros, Mark E. Frankel, Walter Gerhard, Peter C. Doherty
The Journal of Immunology September 1, 1979, 123 (3) 1343-1346;
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Print ISSN 0022-1767        Online ISSN 1550-6606