Abstract
Rabbits have been immunized with the goat antibody population(s) that distinguishes human hemoglobin S (sickle) from A1. After appropriate absorption these rabbit sera bind only the S-specific antibody and not the antibodies that cross-react with hemoglobin A1. S-specific antibody from three individual outbred goats gives reactions of complete immunologic identity in double diffusion reactions in agar with rabbit sera made specific for the antibody that distinguishes hemoglobin S from A1. Quantitative studies of these reactions by radioimmunoassay support the notion that the idiotypic determinants from these three goats have similar antigenic reactivity.
Footnotes
-
↵2 In partial fulfillment of the degree of doctor of philosophy to the graduate school of SUNY at Buffalo. Supported by predoctoral fellowship United States Public Health Service GM46140.
-
↵3 Please send reprint requests to: Robert D. Schreiber, Department of Experimental Pathology, Scripps Clinic and Research Foundation, 476 Prospect Street, La Jolla, California 92037.
-
↵1 This work was supported by designated research funds from the Veteran's Administration and Grant AM10428 from the United States Public Health Service.
- Accepted March 27, 1974.
- Copyright © 1974 by The American Association of Immunologists, Inc.
Pay Per Article - You may access this article (from the computer you are currently using) for 1 day for US$37.50
Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.
Log in using your username and password
In this issue
