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Detection of Specific Surface Antigens on Cells Transformed by Cytomegalovirus with the Techniques of Mixed Hemagglutination and 125I-Labeled Antiglobulin

Robert N. Lausch, Donna M. Murasko, Thomas Albrecht and Fred Rapp
J Immunol May 1, 1974, 112 (5) 1680-1684;
Robert N. Lausch
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Donna M. Murasko
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Thomas Albrecht
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Fred Rapp
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Abstract

Cytomegalovirus (CMV)-transformed hamster cells were examined for the presence of virus-specific membrane antigens by using rabbit antiserum prepared against CMV-infected human embryonic lung (HEL) cells. After absorption with sheep erythrocytes and heterologous hamster tumor cells the antiserum reacted specifically with the CMV-transformed cells in the mixed hemagglutination test. The absorbed antiserum did not react with hamster cells transformed by herpes simplex virus type 2 or PARA-adenovirus 7 or with untransformed hamster embryo fibroblasts. These results were confirmed with the 125I-labeled antiglobulin technique. Absorption with HEL cells rendered the antiserum specific for HEL cells infected with CMV. This reactivity was lost after absorption with 107 CMV-transformed cells but not with 107 hamster embryo fibroblasts. These results establish that CMV-transformed hamster cells express virus-related membrane antigen(s), and that the same antigen(s) is also found on CMV-infected human cells.

Footnotes

  • ↵1 This research was supported by the National Institutes of Health under Public Health Service Contract No. 70-2024.

  • Received December 27, 1973.
  • Copyright © 1974 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 112, Issue 5
1 May 1974
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Detection of Specific Surface Antigens on Cells Transformed by Cytomegalovirus with the Techniques of Mixed Hemagglutination and 125I-Labeled Antiglobulin
Robert N. Lausch, Donna M. Murasko, Thomas Albrecht, Fred Rapp
The Journal of Immunology May 1, 1974, 112 (5) 1680-1684;

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Detection of Specific Surface Antigens on Cells Transformed by Cytomegalovirus with the Techniques of Mixed Hemagglutination and 125I-Labeled Antiglobulin
Robert N. Lausch, Donna M. Murasko, Thomas Albrecht, Fred Rapp
The Journal of Immunology May 1, 1974, 112 (5) 1680-1684;
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Print ISSN 0022-1767        Online ISSN 1550-6606