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Cells Involved in the Immune Response. XX. The “All or None” Nature of the Primary Immune Response (19S Antibody) by Individual Antibody-Forming Cells in the Rabbit

Maxwell Richter, Youssef Behelak, Robert Haasz and Nabih I. Abdou
J Immunol December 1, 1970, 105 (6) 1575-1577;
Maxwell Richter
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Youssef Behelak
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Robert Haasz
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Nabih I. Abdou
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Abstract

The cells that synthesize 19S antibodies in the rabbit following primary intravenous immunization have been shown to be localized in the spleen, using the hemolysis in agar (plaque) technique (1). The temporal relationships are such that the 19S antibody-forming cells (AFC) cannot be detected in appreciable numbers before 4 to 5 days after immunization, but they then increase in number markedly within 24 hr. However, what has not been ascertained is whether this explosive increase in the AFC population is due to a) rapid division of these cells, each progeny being immediately capable of synthesizing large quantities of antibody, b) a synchronous phase of rapid antibody formation by non-dividing cells, or c) increasing amounts of antibody being synthesized by the AFC, thus permitting the detection of increasing numbers of non-dividing AFC. The results presented below strongly support but do not discriminate between the first two hypotheses.

Footnotes

  • ↵2 Medical Research Associate, Medical Research Council, Canada.

  • ↵1 This investigation was supported by a grant from the Medical Research Council, Canada.

  • Copyright, 1970, by The Williams & Wilkins Company
  • Copyright © 1970 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 105, Issue 6
1 Dec 1970
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Cells Involved in the Immune Response. XX. The “All or None” Nature of the Primary Immune Response (19S Antibody) by Individual Antibody-Forming Cells in the Rabbit
Maxwell Richter, Youssef Behelak, Robert Haasz, Nabih I. Abdou
The Journal of Immunology December 1, 1970, 105 (6) 1575-1577;

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Cells Involved in the Immune Response. XX. The “All or None” Nature of the Primary Immune Response (19S Antibody) by Individual Antibody-Forming Cells in the Rabbit
Maxwell Richter, Youssef Behelak, Robert Haasz, Nabih I. Abdou
The Journal of Immunology December 1, 1970, 105 (6) 1575-1577;
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Print ISSN 0022-1767        Online ISSN 1550-6606