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The Action of Pancreatic Extracts on Complement

Arthur Wormall, Hugh Robinson Whitehead and John Gordon
J Immunol May 1, 1925, 10 (3) 587-594;
Arthur Wormall
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Hugh Robinson Whitehead
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John Gordon
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Summary and Conclusions

  1. 1. Pancreatic extracts acting upon whole guinea-pig's serum first destroy the end-piece or albumin fraction. If the reaction is allowed to proceed for a much longer period, both components of the complement are hydrolyzed. In this way the destruction of the complement action of whole serum runs parallel to the destruction by heating at 56°C.

  2. 2. The isolated mid-piece and end-piece fractions are both fairly rapidly destroyed by the enzyme extracts, the latter being more resistant to the enzyme action than the mid-piece fractions. This greater resistance of the end-piece fraction is attributed to the presence in it of the anti-trypsin present in the serum.

  • Received November 13, 1924.
  • Copyright © 1925 by The American Association of Immunologists, Inc.

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The Journal of Immunology
Vol. 10, Issue 3
1 May 1925
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The Action of Pancreatic Extracts on Complement
Arthur Wormall, Hugh Robinson Whitehead, John Gordon
The Journal of Immunology May 1, 1925, 10 (3) 587-594;

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The Action of Pancreatic Extracts on Complement
Arthur Wormall, Hugh Robinson Whitehead, John Gordon
The Journal of Immunology May 1, 1925, 10 (3) 587-594;
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Print ISSN 0022-1767        Online ISSN 1550-6606