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This Article Full Text (PDF) All Versions of this Article: jimmunol.0804104v1 183/2/849    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Google Scholar Articles by Huang, Y. Articles by Born, W. K. PubMed PubMed Citation Articles by Huang, Y. Articles by Born, W. K.

The Influence of IgE-Enhancing and IgE-Suppressive T Cells Changes with Exposure to Inhaled Ovalbumin

Yafei Huang^*,, Niyun Jin^*,, Christina L. Roark^*,, M. Kemal Aydintug^*,, J. M. Wands^*,, Hua Huang^*,, Rebecca L. O’Brien^*, and Willi K. Born^*,

^*Integrated Department of Immunology, National Jewish Health, Denver, CO 80206; University of Colorado, Denver, CO 80206; and Department of Medicine, National Jewish Health, Denver, CO 80206

It has been reported that the IgE response to allergens is influenced by T cells. Intrigued by a study showing that airway challenge of mice with OVA induces in the spleen the development of T cells that suppress the primary IgE response to i.p.-injected OVA-alum, we investigated the T cells involved. We found that the induced IgE suppressors are contained within the V4⁺ subset of T cells of the spleen, that they express V5 and CD8, and that they depend on IFN- for their function. However, we also found that normal nonchallenged mice harbor IgE-enhancing T cells, which are contained within the larger V1⁺ subset of the spleen. In cell transfer experiments, airway challenge of the donors was required to induce the IgE suppressors among the V4⁺ cells. Moreover, this challenge simultaneously turned off the IgE enhancers among the V1⁺ cells. Thus, airway allergen challenge differentially affects two distinct subsets of T cells with nonoverlapping functional potentials, and the outcome is IgE suppression.

Address correspondence and reprint requests to Dr. Willi K. Born, Integrated Department of Immunology, National Jewish Health, 1400 Jackson Street, GB K409, Denver, CO 80206. E-mail address: bornw{at}njc.org