| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Goldman School of Dental Medicine, Department of Periodontology and Oral Biology, Boston University, Boston, MA 02118;
Boston University School of Medicine, Department of Pathology, Boston, MA 02118; and
Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115
Resolvin E1 (RvE1) is a potent proresolving mediator of inflammation derived from omega-3 eicosapentaenoic acid that acts locally to stop leukocyte recruitment and promote resolution. RvE1 displays potent counter-regulatory and tissue-protective actions in vitro and in vivo. Periodontal disease is a local inflammatory disease initiated by bacteria characterized by neutrophil-mediated tissue injury followed by development of a chronic immune lesion. In this study, we report the treatment of established periodontitis using RvE1 as a monotherapy in rabbits compared with structurally related lipids PGE2 and leukotriene B4. PGE2 and leukotriene B4 each enhanced development of periodontitis and worsened the severity of disease. Promotion of resolution of inflammation as a therapeutic target with RvE1 resulted in complete restoration of the local lesion, and reduction in the systemic inflammatory markers C-reactive protein and IL-1β. This report is the first to show that resolution of inflammation by a naturally occurring endogenous lipid mediator results in complete regeneration of pathologically lost tissues, including bone.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported in part by National Institutes of Health (National Institute on Dental and Craniofacial Research) Grant DE016191.
2 Address correspondence and reprint requests to Dr. Thomas E. Van Dyke, Boston University School of Dental Medicine, Department of Periodontology and Oral Biology, 100 East Newton Street, Suite 108, Boston, MA 02118. E-mail address: tvandyke{at}bu.edu
3 Abbreviations used in this paper: LTB4, leukotriene B4; RvE1, Resolvin E1; EPA, eicosapentaenoic acid; CRP, C-reactive protein; PUFA, polyunsaturated fatty acids; TRAP, tartrate-resistant acid phosphatase.
Related articles in The JI:
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
