Cutting Edge: CD25+ Regulatory T Cells Prevent Expansion and Induce Apoptosis of B Cells Specific for Tissue Autoantigens
J Immunol Ludwig-Portugall et al.
181: 4447
Data Supplement
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Supplemental Figure 1-5 (PDF, 928 Kb) -
1. Suppressive activity cells for IgHEL cells in LNs and spleen of ROHhigh mice
2. CD25+ cell–mediated suppression of IgHEL cell proliferation in ROHhigh mice is
detectable also on day 5
3. Depletion of CD25+ cells does not break CD8+ T cell tolerance in ROHhigh mice
4. Treg do not change costimulatory molecule expression on autoreactive B cells
5. Treg do not prevent maturation of autoreactive B cells