The Common -Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

Data Supplement

Files in this Data Supplement:

• Supplemental Figure 1 (PDf, 20.8 Kb)
  - Scatter plots summarizing data of 15 independent experiments assessing (D7) the frequency of PD-1+ CD8+ (top) and CD4+ (bottom) T cells in PBMC treated with IL-2, IL-7, IL-12, IL-15, IL-21 (100 ng/ml each) and anti-CD3/CD28 (5/2 μg/ml). *p < 0.05 treated versus untreated.
• Supplemental Figure 2 (PDF, 36.6 Kb)
  - Frequency of PD-1^hi (A) and PD-L1+ (B) memory/effector and naïve T cell subsets in purified T cells stimulated with γc cytokines or anti-CD3/CD28 for 6 days. (*p < 0.05 comparing treated to untreated; • p < 0.05 comparing T_Eff versus T_N and T_CM).