Data Supplement

Files in this Data Supplement:

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  - Multiple sequence alignment (MSA) from which the pairwise alignment used to build the model (Figure 4) has been extracted. This MSA was obtained by M-coffee (24). It contains 44 sequences, three of which coming from non-human viruses: the Chimpanzee CMV UL18 (gi|20026620|ref|NP_612662.1), the Red Squirrel poxvirus I2L (gi|88769922|gb|ABD51438.1) and the murine CMV antigen H2Kb (gi|223172|prf||0603204A) sequences, sharing 50%, 23% and 22% of identity with human CMV UL18 sequence, respectively. The MSA also contains 9 protein sequences obtained from UL18 genes sequenced from 9 HCMV positive donors (from position 5 to 13 of the MSA). All the other sequences were retrieved by performing a Blast search (22) and using the HHpred server (23). The UL18 query sequence, in the first position of the MSA, is from human CMV, strain AD169 (gi|9625703|ref|NP_039952.1). The range of sequence identity between the entries in our alignment ranges between 99% and 22%. Residues that show a greater than or equal to 97% sequence similarity in the MSA are highlighted with different colors. The image above has been obtained using the BioEdit package.