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Human CD4⁺CD25^low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance

Xu, Q., J. Lee, E. Jankowska-Gan, J. Schultz, D. A. Roennburg, L. D. Haynes, S. Kusaka, H. W. Sollinger, S. J. Knechtle, A. M. VanBuskirk, J. R. Torrealba, and W. J. Burlingham. 2007. Human CD4⁺CD25^low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J. Immunol. 178: 3983–3995.

The last name of the fifth author was misspelled. The correct name is Drew A. Roenneburg.

In Table I, "off insulin" in footnote b and "ceased insulin" in footnote f should be "off immunosuppression." The corrected footnotes are shown below.

^b Kidney transplant from a deceased donor in 1993 for reflux nephropathy. Off immunosuppression 1995; clinical course described as patient DS elsewhere (25) and in Fig. 3.

^f Kidney transplant from a deceased donor in 1986 for chronic glomerulonephritis; off immunosuppression in 2003 due to renal carcinoma in native kidney that was removed in 2004. Current serum creatinine is 1.1 mg/dl.

In Table II, under "Peptide" in the middle column, the labels to the peptides "allo" and "self" are transposed. The corrected table is shown below.

DTH responses to the control peptide, p37-TE, were negative with or without anti-TGF-1 Ab (Fig. 5C).

In the first sentence of the first paragraph under the heading CD4⁺CD25^low T cells show variable CD25 expression but retain allopeptide-specific TGF-1 responsiveness after flow sorting and short-term culture, "CD25^low T cells" should be "CD25^low T_R cells" and "TGF-1" is missing. In the last sentence of the same paragraph, the word "retained" should be "remained." The corrected sentences are shown below.

The adoptive transfer data, coupled with the finding that mainly CD25^low T_R cells were induced to express surface TGF-1 by allopeptide stimulation in vitro (Fig. 4C), raised the possibility that adaptive T_R cells are among the CD4⁺TGF-1⁺ T cells in the graft that showed variable CD25 expression by immunostaining.

However, in cultures with medium alone or peptides, >85% remained negative for CD25 and there was no induction of surface TGF-1 expression by p37-MA relative to p37-TE.

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Xu, Q. Articles by Burlingham, W. J. Search for Related Content PubMed Articles by Xu, Q. Articles by Burlingham, W. J.