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Retraction: Elevated T Regulatory Cells in Long-Term Stable Transplant Tolerance in Rhesus Macaques Induced by Anti-CD3 Immunot oxin and Deoxyspergualin

It has come to our attention that a recently uncovered error compromises some of the data presented in our paper: Asiedu C. K., K. J. Goodwin, G. Balgansuren, S. M. Jenkins, S. Le Bas-Bernardet, U. Jargal, D. M. Neville, Jr., and J. M. Thomas. 2005. Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin. J. Immunol. 175: 8060–8068.

We have learned that assessment of kidney allograft function included several animals that possessed an intrinsic kidney and had not undergone bilateral nephrectomies as reported. Consequently, my coauthors and I think that data and conclusions relating to the duration of operational tolerance were overestimated and invalid.

Although, (1) the in vitro cellular and molecular characterization of rhesus regulatory T cells subsets is entirely valid, and (2) the highest frequency of CD4⁺CD25⁺ T regulatory cells we reported was in recipient 98R317, who underwent bilateral nephrectomy and is currently functioning 5.4 years on his kidney allograft, the relevance of the findings to stable kidney allograft tolerance remains unproven at this point. Thus, in the interest of scientific accuracy and ethical standards, we retract the article cited above.

We express regret to all in the scientific community whose work on tolerance might have been impacted by this unfortunate error.

Clement K. Asiedu

Karen J. Goodwin

Gansuvd Balgansuren

Stacie M. Jenkins

Stéphanie Le Bas-Bernardet

Uuganbayar Jargal

Judith M. Thomas

University of Alabama at Birmingham

Birmingham, AL

David M. Neville, Jr.

National Institutes of Health

Bethesda, MD

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content PubMed PubMed Citation