Correction
for Stone and Stern, J Immunol 176 (3) 1498-1505.
The Journal of Immunology, 2006, 176: 3843.
Copyright © 2006 by The American Association of Immunologists
CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement.
J. D. Stone and
L. J. Stern
Stone, J. D., and L. J. Stern. 2006. CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J. Immunol. 176: 1498–1505
.
In Discussion, the last reference in the paper is incorrect. The corrected sentence and reference are shown below.
It is known that the cytoplasmic domains of several components of the TCR complex tend to homo-oligomerize at high concentrations (41); perhaps ligand-induced clustering of the TCR drives the cytoplasmic domains of proximal receptors to rearrange, exposing the Nck binding epitope and propelling other signaling cascade processes.
41. Sigalov A., D. Aivazian, and L. Stern. 2004. Homooligomerization of the cytoplasmic domain of the T cell receptor zeta chain and of other proteins containing the immunoreceptor tyrosine-based activation motif. Biochemistry 43:2049–61.
