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The Journal of Immunology, 2005, 174: 3839.
Copyright © 2005 by The American Association of Immunologists

LETTERS TO THE EDITOR

JH6 Gene Usage among HCV-Associated MALT Lymphomas Harboring t(14;18) Translocation

Massimo Libra*,{dagger}, Annunziata Gloghini{ddagger}, Patrick M. Navolanic*, Anna L. Zignego§, Valli De Re{dagger} and Antonino Carbone{ddagger}

* Department of Biomedical Sciences, University of Catania, Catania, Italy {dagger} Experimental Oncology 1, and {ddagger} Division of Pathology, Centro di Riferimento Oncologico, National Cancer Institute, Aviano, Italy § Department of Internal Medicine, University of Florence, Florence, Italy

In the September 1, 2004, issue of The Journal of Immunology, Sasso et al. (1) demonstrated an increased frequency of JH6 gene usage among t(14;18) translocations in B cells from hepatitis C virus (HCV)-infected individuals. We have recently detected bcl-2 rearrangement in lymphomas of MALT from HCV-infected patients (2). On the basis of the data reported by Sasso et al. (1), we sought to investigate which JH genes were preferentially used in our series. Nucleotide sequence analysis revealed that bcl-2 was joined to JH6 in all four HCV-associated MALT lymphomas with t(14;18) translocation (see Table I). Our data, supporting the findings by Sasso et al. (1), add that bcl-2 is frequently fused to JH6 in MALT lymphomas from HCV-infected patients. Additional studies are needed to better characterize the role of t(14;18) in lymphomagenesis among HCV-infected individuals.


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  		Table I. DNA sequences at the bcl-2/JH breakpoint of PCR products amplified from all four HCV-associated MALT lymphoma biopsy specimensa

 

References

  1. Sasso, E. H., M. Martinez, S. L. Yarfitz, P. Ghillani, L. Musset, J. C. Piette, P. Cacoub. 2004. Frequent joining of Bcl-2 to a JH6 gene in hepatitis C virus-associated t(14;18). J. Immunol. 173:3549.[Abstract/Free Full Text]
  2. Libra, M., V. De Re, A. Gloghini, D. Gasparotto, L. Gragnani, P. M. Navolanic, S. De Vita, M. C. Mazzarino, A. L. Zignego, A. Carbone, M. Boiocchi. 2004. Detection of bcl-2 rearrangement in mucosa-associated lymphoid tissue lymphomas from patients with hepatitis C virus infection. Haematologica 89:873.[Abstract/Free Full Text]

The Authors Respond

Eric H. Sasso

Abbott Immunology, Abbott Park, IL 60064

The finding by Libra et al. (R1 ) that the t(14;18) in each of four HCV-associated MALT lymphomas used a JH6 gene is consistent with our finding that the t(14;18) found in PBMC of HCV+ subjects are strongly biased to use JH6 genes (R2 ). The authors have previously reported finding t(14;18) in HCV-associated MALT lymphomas (R3 ). An association has not been established, however, between MALT lymphomas and HCV infection or between MALT lymphomas and t(14;18). A better understanding of these areas will help place the present finding in proper context.

References

  1. Libra, M., A. Gloghini, P. M. Navolanic, A. L. Zignego, V. De Re, A. Carbone. 2005. J. Immunol. 174:3839.[Free Full Text]
  2. Sasso, E. H., M. Martinez, S. L. Yarfitz, P. Ghillani, L. Musset, J. C. Piette, P. Cacoub. 2004. Frequent joining of Bcl-2 to a JH6 gene in hepatitis C virus-associated t(14;18). J. Immunol. 173:3549.
  3. Libra, M., A. V. De Re, A. Gloghini, D. Gasparotto, L. Gragnani, P. M. Navolanic, S. Da Vita, M. C. Mazzarino, A. L. Zignego, A. Carbone, M. Boiocchi. 2004. Detection of bcl-2 rearrangement in mucosa-associated lymphoid tissue lymphomas from patients with hepatitis C virus infection. Haematologica 89:873.




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