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FIGURE 1. IL4I1 is most similar to LAAO. Schematic of mouse IL4I1 is shown to scale with N-linked glycosylation sites (N-Gly) (
) and potential tyrosine (Y) phosphorylation sites (
). Predicted FAD cofactor binding domains are indicated by white boxes in the schematic corresponding to the three black lines underneath. The signal peptide and short regions of similarity to many known FAD-binding proteins (MANY) and to specific proteins (phytoene desaturase (PDS), monoamine oxidase (MAO), and tryptophan 2-monooxygenase (TMO)) are shown by the next row of black lines underneath the schematic, corresponding to the gray-spotted boxes. Regions of similarity to bacterial (Bacillus cereus) and eukaryotic (fish (Scomber japonicus) and snake (Crotalus atrox, C. adamanteus)) LAAO are shown by the remaining black lines underneath the schematic of IL4I1.
