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MBP-Specific Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice

Neuroimmunology Unit-Dibit, San Raffaele Scientific Institute, Milan, Italy

Some of the most prominent scientists in the field of neuroimmunology (C. Raine, C. C. Bernard, and W. Hickey) have reported in the past that C57BL/6 mice are resistant to experimental autoimmune encephalomyelitis (EAE) induced by active immunization with myelin basic protein (MBP) (for example, Ref. 1), and the only studies reporting clinical signs of MBP-specific EAE in C57BL/6 mice use the combination of passive transfer of encephalitogenic T cells with subsequent antigenic re-challenge (2, 3). It is thus surprising to read the Cutting Edge by Faunce et al. (4) reporting a series of experiments obtained in C57BL/6 mice affected by EAE induced only by active immunization with MBP in complete Freund’s adjuvant and by i.p. injection of pertussis toxin. The reference cited in Materials and Methods is not appropriate, since it refers to EAE obtained in a different mouse strain with a different Ag (5). The authors should discuss this issue in more detail since it is, to my knowledge, the first study contradicting the previously reported resistance of C57BL/6 mice to actively induced MBP-EAE.

References

1. Bernard, C. C.. 1976. Experimental autoimmune encephalomyelitis in mice: genetic control of susceptibility. J. Immunogenet. 3:263.[Abstract/Free Full Text]
2. Shaw, M. K., C. Kim, K. L. Ho, R. P. Lisak, H. Y. Tse. 1992. A combination of adoptive transfer and antigenic challenge induces consistent murine experimental autoimmune encephalomyelitis in C57BL/6 mice and other reputed resistant strains. J. Neuroimmunol. 39:139.[Abstract/Free Full Text]
3. Tsai, C. Y., N. H. Chow, T. S. Ho, H. Y. Lei. 1997. Intracerebral injection of myelin basic protein (MBP) induces inflammation in brain and causes paraplegia in MBP-sensitized B6 mice. Clin. Exp. Immunol. 109:127.[Abstract]
4. Faunce, D. E., A. Terajewicz, J. Stein-Streilein. 2004. Cutting edge: in vitro-generated tolerogenic APC induce CD8⁺ T regulatory cells that can suppress ongoing experimental autoimmune encephalomyelitis. J. Immunol. 172:1991.[Abstract/Free Full Text]
5. Bettelli, E., M. P. Das, E. D. Howard, H. L. Weiner, R. A. Sobel, V. K. Kuchroo. 1998. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J. Immunol. 161:3299.[Abstract/Free Full Text]

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