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The Journal of Immunology, 2003, 171: 2767-2768.
Copyright © 2003 by The American Association of Immunologists

LETTERS TO THE EDITOR

IL-4 Is Not a Key Profibrotic Cytokine in Bleomycin-Induced Lung Fibrosis Model

Gabriel Izbicki and Raphael Breuer

Lung Cellular and Molecular Biology Laboratory Institute of Pulmonology Hadassah University Hospital and The Hebrew University-Hadassah Medical School Jerusalem, Israel

We read with interest the publication of Huaux et al. (1) concerning the dual roles of IL-4 in lung injury and fibrosis. In another recent study (2), bleomycin was injected intratracheally into three groups of C57BL/6JU mice: transgenic animals with overexpression of IL-4, IL-4-deficient mice, and wild-type mice. Lung fibrosis was evaluated at 14 days by hydroxyproline measurements and by quantitative image analysis of fibrosis fraction and alveolar wall area fraction. In the early phase, similar to Huaux et al. (1), there was no difference between IL-4-deficient and wild-type mice in bronchoalveolar cellularity, hydroxyproline, and fibrosis scores (2). However, since hydroxyproline and fibrosis scores were significantly lower in transgenic animals with overexpression of IL-4 as compared with IL-4-deficient mice, IL-4 does not seem to be a key profibrotic cytokine in the murine model of bleomycin-induced lung fibrosis.

References

  1. Huaux, F., T. Liu, B. McGarry, M. Ullenbruch, S. H. Phan. 2003. Dual roles of IL-4 in lung injury and fibrosis. J. Immunol. 170:2083.[Abstract/Free Full Text]
  2. Izbicki, G., R. Or, T. Christensen, M. J. Segel, A. Fine, R. H. Goldstein, R. Breuer. 2002. Bleomycin-induced lung fibrosis in IL-4-overexpressing and knockout mice. Am. J. Physiol. 283:L1110.



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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. Cavarra, F. Carraro, S. Fineschi, A. Naldini, B. Bartalesi, A. Pucci, and G. Lungarella
Early response to bleomycin is characterized by different cytokine and cytokine receptor profiles in lungs
Am J Physiol Lung Cell Mol Physiol, December 1, 2004; 287(6): L1186 - L1192.
[Abstract] [Full Text] [PDF]

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