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Retraction for Tulin et al., J Immunol 167 (11) 6338-6347.
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The Journal of Immunology, 2003, 170: 1593.
Copyright © 2003 by The American Association of Immunologists

Letter of Retraction

SF20/IL-25, a Novel Bone Marrow Stroma-Derived Growth Factor That Binds to Mouse Thymic Shared Antigen-1 and Supports Lymphoid Cell Proliferation

Edgardo E. Tulin, Nobuhisa Onoda, Yasuhiko Nakata, Masatsugu Maeda, Masakazu Hasegawa, Hitoshi Nomura and Toshio Kitamura

We wish to retract the paper by Edgardo E. Tulin, Nobuhisa Onoda, Yasuhiko Nakata, Masatsugu Maeda, Masakazu Hasegawa, Hitoshi Nomura, and Toshio Kitamura, "SF20/IL-25, a Novel Bone Marrow Stroma-Derived Growth Factor That Binds to Mouse Thymic Shared Antigen-1 and Supports Lymphoid Cell Proliferation," The Journal of Immunology 2001;167:6338-6347 .

In the article above, we isolated a novel secreted bone marrow stroma-derived growth factor, SF20/IL-25, which supports lymphoid cell proliferation via mouse thymic shared Ag-1. In subsequent work, we were unable to reproduce our published findings reported in Figs. 4B, 5C, 6B, and 8C of the article. At this point, we are unable to explain why these prior experiments were flawed, but some minor contaminant in the purified SF20 in the original experiments could have brought the inconsistency. Since the original data is indispensable for demonstration of the physiological role of SF20, the published findings are unsound. Therefore, we would like to inform the scientific community of this error.

Edgardo E. Tulin

Nobuhisa Onoda

Yasuhiko Nakata

Masatsugu Maeda

Masakazu Hasegawa

Hitoshi Nomura

Chugai Research Institute for Molecular Medicine

Ibaraki, Japan

Toshio Kitamura

Department of Hematopoietic Factors

Institute of Medical Science

University of Tokyo

Tokyo, Japan




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