Cutting Edge: Monarch-1: A Pyrin/Nucleotide-Binding Domain/Leucine-Rich Repeat Protein That Controls Classical and Nonclassical MHC Class I Genes
J Immunol
Williams et al. 170 (11): 5354.
Characterization of Monarch-1 and its splice forms
Files in this Data Supplement:
Parts A and B -
(A) Sequence of full length isoform I
of the Monarch-1 mRNA. The open reading frame for the human Monarch-1
protein is underlined. The transcriptional start site of this mRNA was
previously incorrectly identified and named RNO2. The sequence similarity between Monarch-1 and RNO2 mRNA are depicted in bold. (B) Deduced amino acid sequence of Monarch-1 contains an N-terminal PYRIN domain, an NBD (underlined) and several C-terminal leucine rich repeats (LRR) denoted by arrows.
Parts C and D -
(C) Sequence of isoform II of the
Monarch-1 mRNA missing exon 9.
(D) Deduced amino acid sequence of isoform II of
Monarch-1. The exon 9 deletion site is denoted by a large
arrowhead.
Parts E and F -
(E) Sequence of isoform III of the
Monarch-1 mRNA missing exons 7 and 8.
(F) Deduced amino acid sequence of isoform II of
Monarch-1. The exon 7, 8 deletion site is denoted by a large
arrowhead.
Parts G and H -
(G) Sequence of isoform IV of the
Monarch-1 mRNA missing exons 7 through 9.
(H) Deduced amino acid sequence of isoform IV of
Monarch-1. The exon 7 to 9 deletion site is denoted by a large
arrowhead.